BURIXAFOR

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 2G17Y0Q20G

Structure
InChI Key QLVSJMZJSABWRX-UHFFFAOYSA-N
Smile Nc1cc(N2CCN(CCP(=O)(O)O)CC2)nc(NCC2CCC(CNCCCNC3CCCCC3)CC2)n1
InChI
InChI=1S/C27H51N8O3P/c28-25-19-26(35-15-13-34(14-16-35)17-18-39(36,37)38)33-27(32-25)31-21-23-9-7-22(8-10-23)20-29-11-4-12-30-24-5-2-1-3-6-24/h19,22-24,29-30H,1-18,20-21H2,(H2,36,37,38)(H3,28,31,32,33)

Physicochemical Descriptors

Property Name Value
Molecular Formula C27H51N8O3P
Molecular Weight 566.73
AlogP 2.48
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 6.0
Number of Rotational Bond 14.0
Polar Surface Area 151.9
Molecular species ZWITTERION
Aromatic Rings 1.0
Heavy Atoms 39.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST C-X-C chemokine receptor type 4 antagonist PubMed Other

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hodgkin Disease 2 D006689 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 1 D064129 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545224
FDA SRS 2G17Y0Q20G
PubChem 44479007
SureChEMBL SCHEMBL13354172
ZINC ZINC000140585706
CONTENTS