| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | C7C7U6YEAO |
Structure
| InChI Key | RSMYFSPOTCDHHJ-GOSISDBHSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C25H33N7O3 |
| Molecular Weight | 479.59 |
| AlogP | 2.06 |
| Hydrogen Bond Acceptor | 9.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 88.33 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 35.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
|
- | - | - | 1259 | - | |
|
Epigenetic regulator
Reader
Bromodomain
|
- | 5-1600 | - | 5-159 | - | |
|
Epigenetic regulator
Writer
Histone acetyltransferase
p300/CBP family
|
- | - | - | 6310 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Lymphoma, Large B-Cell, Diffuse | 1 | D016403 | ClinicalTrials |
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4078100 |
| FDA SRS | C7C7U6YEAO |
| PDB | XNH |
| PubChem | 118693659 |
| SureChEMBL | SCHEMBL17477306 |
| ZINC | ZINC000575441177 |
CONTENTS