AVIBACTAM SODIUM

Search structure
Synonyms:
Status: Approved (2015)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 9V824P8TAI

Structure
InChI Key RTCIKUMODPANKX-JBUOLDKXSA-M
Smile NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)[O-].[Na+]
InChI
InChI=1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H10N3NaO6S
Molecular Weight 287.23
AlogP -1.53
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 130.24
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 17.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial beta-lactamase TEM inhibitor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 650 - - -
Enzyme Protease Serine protease Serine protease unclassified
- 590 - - -
Enzyme Transferase
- - - - 15.94

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Infections 1 D007239 ClinicalTrials

Cross References

Resources Reference
ChEBI 85982
ChEMBL CHEMBL2107817
FDA SRS 9V824P8TAI
PubChem 24944097
SureChEMBL SCHEMBL14247700
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