| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | SAY8KVM4HU |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H15ClF2N4O3 |
| Molecular Weight | 468.85 |
| AlogP | 5.0 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 110.1 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 33.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Hepatocyte growth factor receptor inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Met family
|
- | 1.7 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase VEGFR family
|
- | 15 | - | - | - | |
|
Enzyme
Transferase
|
- | - | - | - | ||
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -24.38--9.09 |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545119 |
| FDA SRS | SAY8KVM4HU |
CONTENTS