RASEGLURANT

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 66UCJ8Z8L1

Structure
InChI Key MEDCLNYIYBERKO-UHFFFAOYSA-N
Smile Cc1cc(C)c(N)c(C#Cc2cccc(F)c2)n1
InChI
InChI=1S/C15H13FN2/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12/h3-5,8-9H,17H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H13FN2
Molecular Weight 240.28
AlogP 2.82
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 0.0
Polar Surface Area 38.91
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 18.0

Pharmacology

Action Mechanism of Action Reference
MODULATOR Metabotropic glutamate receptor 5 modulator PMC PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) Neurotransmitter receptor (family C GPCR) Metabotropic glutamate receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Migraine Disorders 2 D008881 ClinicalTrials
Gastroesophageal Reflux 2 D005764 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3545036
EPA CompTox DTXSID40226707
FDA SRS 66UCJ8Z8L1
PubChem 10331863
SureChEMBL SCHEMBL3874524
ZINC ZINC000003821213
CONTENTS