| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | H2OL3Q4XRD |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C27H23FN4O4S |
| Molecular Weight | 518.57 |
| AlogP | 4.59 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 101.58 |
| Molecular species | None |
| Aromatic Rings | 4.0 |
| Heavy Atoms | 37.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Hepatocyte growth factor receptor inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Axl family
|
- | 15 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Met family
|
- | 32-32 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase PDGFR family
|
- | 0.81 | - | - | - | |
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase VEGFR family
|
- | 30-30 | - | - | - |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545144 |
| FDA SRS | H2OL3Q4XRD |
CONTENTS