RISEDRONIC ACID

Search structure
Synonyms:
Status: Approved (1998)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: M05BA07
UNII: KM2Z91756Z

Structure
InChI Key IIDJRNMFWXDHID-UHFFFAOYSA-N
Smile O=P(O)(O)C(O)(Cc1cccnc1)P(=O)(O)O
InChI
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)

Physicochemical Descriptors

Property Name Value
Molecular Formula C7H11NO7P2
Molecular Weight 283.11
AlogP -0.37
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 5.0
Number of Rotational Bond 4.0
Polar Surface Area 148.18
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 17.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- 0-860 - 0-82 57-94
Enzyme
- 0-860 - 0-82 57-94
Unclassified protein
80 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteoporosis, Postmenopausal 3 D015663 ClinicalTrials
Bone Diseases, Metabolic 3 D001851 ClinicalTrials
Prostatic Neoplasms 3 D011471 ClinicalTrials
Spinal Cord Injuries 3 D013119 ClinicalTrials
Osteitis Deformans 3 D010001 ClinicalTrials
Back Pain 3 D001416 ClinicalTrials
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Osteoporosis 3 D010024 ClinicalTrials
Fibrous Dysplasia of Bone 2 D005357 ClinicalTrials
Menopause 2 D008593 ClinicalTrials
Lung Neoplasms 2 D008175 ClinicalTrials
Chronic Kidney Disease-Mineral and Bone Disorder 1 D012080 ClinicalTrials

Cross References

Resources Reference
ChEBI 8869
ChEMBL CHEMBL923
DrugBank DB00884
DrugCentral 2387
EPA CompTox DTXSID2023563
FDA SRS KM2Z91756Z
Human Metabolome Database HMDB0015022
Guide to Pharmacology 3176
KEGG C08233
PDB RIS
PharmGKB PA451255
PubChem 5245
SureChEMBL SCHEMBL18378
ZINC ZINC000001531009
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