DUTETRABENAZINE

Search structure
Synonyms:
Status: Approved (2017)
Entry Type: Small molecule
Molecule Category: UNKNOWN

Structure
InChI Key MKJIEFSOBYUXJB-LIJFRPJRSA-N
Smile [2H]C([2H])([2H])Oc1cc2c(cc1OC([2H])([2H])[2H])C1CC(=O)C(CC(C)C)CN1CC2
InChI
InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/i3D3,4D3

Physicochemical Descriptors

Property Name Value
Molecular Formula C19H27NO3
Molecular Weight 323.47
AlogP 3.24
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 38.77
Molecular species NEUTRAL
Aromatic Rings 1.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Synaptic vesicular amine transporter inhibitor FDA

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Huntington Disease 4 D006816 ClinicalTrials
Movement Disorders 3 D009069 ClinicalTrials
Tourette Syndrome 3 D005879 ClinicalTrials
Cerebral Palsy 3 D002547 ClinicalTrials
Dystonic Disorders 1 D020821 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3137326
DrugCentral 5226
SureChEMBL SCHEMBL13321841
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