TRAMIPROSATE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 5K8EAX0G53

Structure
InChI Key SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smile NCCCS(=O)(=O)O
InChI
InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

Physicochemical Descriptors

Property Name Value
Molecular Formula C3H9NO3S
Molecular Weight 139.18
AlogP -0.78
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 80.39
Molecular species ZWITTERION
Aromatic Rings 0.0
Heavy Atoms 8.0

Pharmacology

Action Mechanism of Action Reference
STABILISER Beta amyloid A4 protein stabiliser PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor
- 300 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- - - - 18
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) Neurotransmitter receptor (family C GPCR) GABA-B receptor
- 2000-30000 - - -
Membrane receptor
- 2000-30000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 3 D000544 ClinicalTrials

Cross References

Resources Reference
ChEBI 1457
ChEMBL CHEMBL149082
DrugBank DB06527
EPA CompTox DTXSID80190352
FDA SRS 5K8EAX0G53
KEGG C03349
PDB A20
PubChem 1646
SureChEMBL SCHEMBL26759
ZINC ZINC000001529636
CONTENTS