VIXOTRIGINE

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: QQS4J85K6Y

Structure
InChI Key JESCETIFNOFKEU-SJORKVTESA-N
Smile NC(=O)[C@@H]1CC[C@H](c2ccc(OCc3ccccc3F)cc2)N1
InChI
InChI=1S/C18H19FN2O2/c19-15-4-2-1-3-13(15)11-23-14-7-5-12(6-8-14)16-9-10-17(21-16)18(20)22/h1-8,16-17,21H,9-11H2,(H2,20,22)/t16-,17+/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H19FN2O2
Molecular Weight 314.36
AlogP 2.68
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 5.0
Polar Surface Area 64.35
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 23.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Sodium channel protein type IX alpha subunit blocker Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- 10000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Trigeminal Neuralgia 3 D014277 ClinicalTrials
Neuralgia 2 D009437 ClinicalTrials
Erythromelalgia 2 D004916 ClinicalTrials
Radiculopathy 2 D011843 ClinicalTrials
Bipolar Disorder 1 D001714 ClinicalTrials
Diabetic Neuropathies 1 D003929 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3544913
DrugBank DB11706
FDA SRS QQS4J85K6Y
PubChem 16046068
SureChEMBL SCHEMBL310473
ZINC ZINC000034892269
CONTENTS