SURAMIN HEXASODIUM

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 89521262IH

Structure
InChI Key VAPNKLKDKUDFHK-UHFFFAOYSA-H
Smile Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)[O-])c3cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)[O-])c5cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c45)ccc3C)c2)c1.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChI
InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6

Physicochemical Descriptors

Property Name Value
Molecular Formula C51H34N6Na6O23S6
Molecular Weight 1429.19
AlogP None
Hydrogen Bond Acceptor None
Hydrogen Bond Donor None
Number of Rotational Bond None
Polar Surface Area None
Molecular species None
Aromatic Rings None
Heavy Atoms None

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Acidic fibroblast growth factor inhibitor PubMed PubMed PubMed PubMed PubMed PubChem
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C1A family
- - - - 32
Epigenetic regulator Eraser Histone deacetylase HDAC class III
- 1200-1200 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Leukotriene receptor
- - - - 33
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Purine receptor
- - - - 15
Transcription factor
- 10400 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Prostatic Neoplasms, Castration-Resistant 3 D064129 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Acute Kidney Injury 2 D058186 ClinicalTrials
Prostatic Neoplasms 2 D011471 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Adrenal Cortex Neoplasms 2 D000306 ClinicalTrials
Central Nervous System Neoplasms 2 D016543 ClinicalTrials
Colorectal Neoplasms 1 D015179 ClinicalTrials
Child Development Disorders, Pervasive 1 D002659 ClinicalTrials
Urinary Bladder Neoplasms 1 D001749 ClinicalTrials
Breast Neoplasms 1 D001943 ClinicalTrials
Hand, Foot and Mouth Disease 1 D006232 ClinicalTrials
Carcinoma, Renal Cell 1 D002292 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 9364
ChEMBL CHEMBL413376
EPA CompTox DTXSID30156024
FDA SRS 89521262IH
SureChEMBL SCHEMBL414636
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