| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 94E9UR0RFR |
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H20N2O5S |
| Molecular Weight | 424.48 |
| AlogP | 3.24 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 0.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 90.62 |
| Molecular species | None |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 30.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Serine/threonine-protein kinase PLK1 inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Kinase
Protein Kinase
TK protein kinase group
Tyrosine protein kinase Met family
|
- | - | 1393 | - | - | |
|
Enzyme
Transferase
|
- | - | - | - | 2.292 | |
|
Epigenetic regulator
Eraser
Histone deacetylase
HDAC class IIb
|
- | - | - | - | -1.75-16.98 |
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL3545431 |
| FDA SRS | 94E9UR0RFR |
| PubChem | 9888590 |
CONTENTS