GLUMETINIB

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 7JTT036WGX

Structure
InChI Key RYBLECYFLJXEJX-UHFFFAOYSA-N
Smile Cn1cc(-c2cnc3cnn(S(=O)(=O)c4cnc5ccc(-c6cnn(C)c6)cn45)c3c2)cn1
InChI
InChI=1S/C21H17N9O2S/c1-27-11-16(7-24-27)14-3-4-20-23-10-21(29(20)13-14)33(31,32)30-19-5-15(6-22-18(19)9-26-30)17-8-25-28(2)12-17/h3-13H,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C21H17N9O2S
Molecular Weight 459.5
AlogP 2.12
Hydrogen Bond Acceptor 11.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 117.79
Molecular species NEUTRAL
Aromatic Rings 6.0
Heavy Atoms 33.0

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Neoplasms 1 D009369 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4594400
FDA SRS 7JTT036WGX
PubChem 117797905
SureChEMBL SCHEMBL16368659
CONTENTS