TUCIDINOSTAT

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 87CIC980Y0

Structure
InChI Key SZMJVTADHFNAIS-BJMVGYQFSA-N
Smile Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)/C=C/c2cccnc2)cc1
InChI
InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H19FN4O2
Molecular Weight 390.42
AlogP 3.38
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 6.0
Polar Surface Area 97.11
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 29.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme
- 2100 - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class I
- 100-296 - - 91
Epigenetic regulator Eraser Histone deacetylase HDAC class IIa
- 7160 - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 100-235 - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IV
- 400-760 - - -
Unclassified protein
- 330 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Lymphoma, T-Cell, Peripheral 3 D016411 ClinicalTrials
Lymphoma, T-Cell, Peripheral 3 D016411 ClinicalTrials
Breast Neoplasms 3 D001943 ClinicalTrials
Lymphoma, Large B-Cell, Diffuse 3 D016403 ClinicalTrials
Lymphoma 2 D008223 ClinicalTrials
HIV Infections 2 D015658 ClinicalTrials
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Lymphoma, Non-Hodgkin 2 D008228 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Multiple Myeloma 2 D009101 ClinicalTrials
Thrombocytopenia 2 D013921 ClinicalTrials
Hodgkin Disease 2 D006689 ClinicalTrials
Sarcoma 2 D012509 ClinicalTrials
Lymphoma, T-Cell, Cutaneous 2 D016410 ClinicalTrials
Triple Negative Breast Neoplasms 2 D064726 ClinicalTrials
Urinary Bladder Neoplasms 2 D001749 ClinicalTrials
Leukemia, Biphenotypic, Acute 2 D015456 ClinicalTrials
Carcinoma, Adenoid Cystic 2 D003528 ClinicalTrials
Immunoblastic Lymphadenopathy 2 D007119 ClinicalTrials
Granuloma, Lethal Midline 2 D006103 ClinicalTrials
Colorectal Neoplasms 2 D015179 ClinicalTrials
Lymphoma, Follicular 2 D008224 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 2 D054198 ClinicalTrials
Acquired Immunodeficiency Syndrome 1 D000163 ClinicalTrials
Uterine Cervical Neoplasms 1 D002583 ClinicalTrials
Leukemia, Myeloid, Acute 1 D015470 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 135918
ChEMBL CHEMBL3621988
DrugBank DB06334
DrugCentral 4973
FDA SRS 87CIC980Y0
PubChem 12136798
SureChEMBL SCHEMBL4483082
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