PROGLUMIDE

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: A02BX06
UNII: EPL8W5565D

Structure
InChI Key DGMKFQYCZXERLX-UHFFFAOYSA-N
Smile CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H26N2O4
Molecular Weight 334.42
AlogP 2.3
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 86.71
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Cholecystokinin receptor antagonist PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 105

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Non-alcoholic Fatty Liver Disease 1 D065626 ClinicalTrials
Liver Cirrhosis 0 D008103 ClinicalTrials

Cross References

Resources Reference
ChEBI 32058
ChEMBL CHEMBL316561
DrugBank DB13431
DrugCentral 2281
EPA CompTox DTXSID7023516
FDA SRS EPL8W5565D
Guide to Pharmacology 893
PubChem 4922
SureChEMBL SCHEMBL93339
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