TARLOXOTINIB

Search structure
Synonyms:
Status: Phase 2
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: H8768UL06V

Structure
InChI Key MUJMYVFVAWFUJL-SNAWJCMRSA-O
Smile Cn1cnc([N+](=O)[O-])c1C[N+](C)(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(Cl)c(Br)c3)ncnc2cn1
InChI
InChI=1S/C24H23BrClN9O3/c1-33-14-30-24(34(37)38)20(33)12-35(2,3)8-4-5-22(36)32-21-10-16-19(11-27-21)28-13-29-23(16)31-15-6-7-18(26)17(25)9-15/h4-7,9-11,13-14H,8,12H2,1-3H3,(H-,27,28,29,31,32,36)/p+1/b5-4+

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H24BrClN9O3+
Molecular Weight 601.87
AlogP 4.6
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 9.0
Polar Surface Area 140.76
Molecular species NEUTRAL
Aromatic Rings 4.0
Heavy Atoms 38.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Epidermal growth factor receptor inhibitor

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Carcinoma, Non-Small-Cell Lung 2 D002289 ClinicalTrials
Carcinoma, Squamous Cell 2 D002294 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4297661
DrugBank DB14944
FDA SRS H8768UL06V
Guide to Pharmacology 9409
PubChem 51038316
SureChEMBL SCHEMBL19733352
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