Synonyms: | |
Status: | Phase 2 |
Entry Type: | Small molecule |
Molecule Category: | UKNOWN |
UNII: | 6T4O391P5Y |
InChI Key | FJCDSQATIJKQKA-UHFFFAOYSA-N |
---|---|
Smile | |
InChI |
|
Property Name | Value |
---|---|
Molecular Formula | C22H18FN7 |
Molecular Weight | 399.43 |
AlogP | 4.24 |
Hydrogen Bond Acceptor | 6.0 |
Hydrogen Bond Donor | 2.0 |
Number of Rotational Bond | 5.0 |
Polar Surface Area | 83.79 |
Molecular species | NEUTRAL |
Aromatic Rings | 5.0 |
Heavy Atoms | 30.0 |
Action | Mechanism of Action | Reference |
---|---|---|
INHIBITOR | TGF-beta receptor type I inhibitor | PubMed |
Mesh Heading | Maximum Phase | Mesh ID | Reference |
---|---|---|---|
Myeloproliferative Disorders | 2 | D009196 | ClinicalTrials |
Urinary Bladder Neoplasms | 2 | D001749 | ClinicalTrials |
Stomach Neoplasms | 2 | D013274 | ClinicalTrials |
Stomach Neoplasms | 2 | D013274 | ClinicalTrials |
Carcinoma, Non-Small-Cell Lung | 2 | D002289 | ClinicalTrials |
Fibromatosis, Aggressive | 1 | D018222 | ClinicalTrials |
Neoplasms | 1 | D009369 | ClinicalTrials |
Multiple Myeloma | 1 | D009101 | ClinicalTrials |
Pancreatic Neoplasms | 1 | D010190 | ClinicalTrials |
Myelodysplastic Syndromes | 1 | D009190 | ClinicalTrials |
Resources | Reference |
---|---|
ChEMBL | CHEMBL3260567 |
DrugBank | DB15310 |
FDA SRS | 6T4O391P5Y |
Guide to Pharmacology | 8107 |
SureChEMBL | SCHEMBL250076 |
ZINC | ZINC000113391423 |