FLUOXETINE HYDROCHLORIDE

Search structure
Synonyms:
Status: Approved (1987)
Entry Type: Small molecule
Molecule Category: Parent
UNII: I9W7N6B1KJ

Structure
InChI Key GIYXAJPCNFJEHY-UHFFFAOYSA-N
Smile CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1.Cl
InChI
InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C17H19ClF3NO
Molecular Weight 345.79
AlogP 4.44
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 21.26
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Serotonin transporter inhibitor PubMed PubMed DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
- - - 72 -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family
- 150 - 1 44

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Depressive Disorder 2 D003866 ClinicalTrials
Panic Disorder 2 D016584 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 145458
ChEMBL CHEMBL1201082
EPA CompTox DTXSID7020635
FDA SRS I9W7N6B1KJ
SureChEMBL SCHEMBL33384
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