FLINDOKALNER

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: J57O328W4W

Structure
InChI Key ULYONBAOIMCNEH-HNNXBMFYSA-N
Smile COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(C(F)(F)F)ccc21
InChI
InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C16H10ClF4NO2
Molecular Weight 359.71
AlogP 4.53
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 38.33
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
OPENER Calcium-activated potassium channel subunit alpha-1 opener PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Calcium-activated potassium channel
352 - - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
2400 - - - -

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL266510
EPA CompTox DTXSID70870176
FDA SRS J57O328W4W
Guide to Pharmacology 2307
SureChEMBL SCHEMBL4877314
ZINC ZINC000000839816
CONTENTS