GAMOLENIC ACID

Search structure


Synonyms:	18:3(N-6) (6z,9z,12z-octadecatrienoic acid C18:3 (n-6) Delta-linolenic acid Efamast 40 Efamast 80 Epoc Epogam Epogam 40 Epogam 80 Epogam paed Gamma-linolenate .gamma.-linolenic acid Gamma linolenic acid Gammalinolenic acid Gammolin Gam-o Gamolenic acid Gamolenic-acid Gamophase Kentogam Lin-gam NDI 609 Sonova 400 Unigam
Status:	Approved
Entry Type:	Small molecule
Molecule Category:	Parent
ATC:	D11AX02
UNII:	78YC2MAX4O

Structure


InChI Key	VZCCETWTMQHEPK-QNEBEIHSSA-N
Smile	CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O
InChI	InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H30O2
Molecular Weight	278.44
AlogP	5.66
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	13.0
Polar Surface Area	37.3
Molecular species	ACID
Aromatic Rings	0.0
Heavy Atoms	20.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	30000	-	-	-
Enzyme Transferase	-	-	-	-	41-78
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Free fatty acid receptor	4620	-	-	-	-
Membrane receptor	4620	30000	-	-	-
Surface antigen	-	30000	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 1	-	270-270	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 2	-	750	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C Nuclear hormone receptor subfamily 1 group C member 3	-	2200	-	-	-

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Arthritis, Rheumatoid	3	D001172	ClinicalTrials
Asthma	1	D001249	ClinicalTrials

Cross References

Resources	Reference
ChEBI	28661
ChEMBL	CHEMBL464982
DrugBank	DB13854
DrugCentral	1276
EPA CompTox	DTXSID7046170
FDA SRS	78YC2MAX4O
Human Metabolome Database	HMDB0003073
Guide to Pharmacology	4710
KEGG	C06426
SureChEMBL	SCHEMBL19418
ZINC	ZINC000003777423

CONTENTS