| Synonyms: | |
| Status: | Phase 1 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | 2LHZ9ZC3YO |
Structure
| InChI Key | YCXOHEXZVKOGEV-DNRQZRRGSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C30H42FN5O3 |
| Molecular Weight | 539.7 |
| AlogP | 2.31 |
| Hydrogen Bond Acceptor | 7.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 7.0 |
| Polar Surface Area | 81.17 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 2.0 |
| Heavy Atoms | 39.0 |
Pharmacology
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
|
- | 0-12 | - | - | - | |
|
Ion channel
Voltage-gated ion channel
Potassium channels
Voltage-gated potassium channel
|
- | 69000 | - | - | 30 | |
|
Other cytosolic protein
|
- | 3 | - | - | - | |
|
Unclassified protein
|
- | - | - | 800 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials |
| Lymphoma | 1 | D008223 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4173974 |
| DrugBank | DB16160 |
| FDA SRS | 2LHZ9ZC3YO |
| SureChEMBL | SCHEMBL16830758 |
CONTENTS