FOSFOMYCIN

Search structure
Synonyms:
Status: Approved (1996)
Entry Type: Small molecule
Molecule Category: UKNOWN
ATC: J01XX01
UNII: 2N81MY12TE

Structure
InChI Key YMDXZJFXQJVXBF-STHAYSLISA-N
Smile C[C@@H]1O[C@@H]1P(=O)(O)O
InChI
InChI=1S/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C3H7O4P
Molecular Weight 138.06
AlogP -0.09
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 70.06
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 8.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- 100-8800 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor
- - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Staphylococcal Infections 3 D013203 ClinicalTrials
Urinary Tract Infections 3 D014552 ClinicalTrials
Gonorrhea 3 D006069 ClinicalTrials
Pneumonia, Bacterial 2 D018410 ClinicalTrials
Neonatal Sepsis 2 D000071074 ClinicalTrials
Neoplasms 2 D009369 ClinicalTrials
Pyelonephritis 2 D011704 ClinicalTrials
Appendicitis 2 D001064 ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 D054198 ClinicalTrials
Pseudomonas Infections 1 D011552 ClinicalTrials
Osteomyelitis 0 D010019 ClinicalTrials
Infections 0 D007239 ClinicalTrials

Cross References

Resources Reference
ChEBI 28915
ChEMBL CHEMBL1757
DrugBank DB00828
DrugCentral 1243
EPA CompTox DTXSID4048480
FDA SRS 2N81MY12TE
Human Metabolome Database HMDB0014966
Guide to Pharmacology 10813
KEGG C06454
PDB FCN
PharmGKB PA164748039
SureChEMBL SCHEMBL50951
ZINC ZINC000001530427
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