LEVOTHYROXINE SODIUM

Search structure


Synonyms:	Eferox Eltroxin Euthyrox Evotrox Levaxin Levolet Levo-t Levothroid Levothyroid Levothyrox Levothyroxine sodium Levothyroxine sodium anhydrous Levothyroxine sodium hydrate Levoxine Levoxyl Liotrix (t4) L-thyroxine henning Monosodium l-thyroxine hydrate Novothyrox NSC-259940 Oroxine Soloxine Synthroid T4 T4 (liotrix) Thyquidity Thyrol L Thyro-tabs Thyroxine Thyroxine sodium Thyroxine sodium salt Tirosint Tirosint-sol Unithroid
Status:	Approved (2000)
Entry Type:	Small molecule
Molecule Category:	UKNOWN
ATC:	H03AA01
UNII:	B82379R9W0

Structure


InChI Key	ANMYAHDLKVNJJO-LTCKWSDVSA-M
Smile	N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+]
InChI	InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m0../s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H12I4NNaO5
Molecular Weight	816.87
AlogP	4.56
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	92.78
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	24.0

Pharmacology

Action	Mechanism of Action	Reference
AGONIST	Thyroid hormone receptor agonist	Wikipedia Wikipedia FDA

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Bipolar Disorder	2	D001714	ClinicalTrials
Pain	1	D010146	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Cross References

Resources	Reference
ChEBI	6447
ChEMBL	CHEMBL2103741
FDA SRS	B82379R9W0
SureChEMBL	SCHEMBL2327406

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