LEVOTHYROXINE SODIUM

Search structure
Synonyms:
Status: Approved (2000)
Entry Type: Small molecule
Molecule Category: UNKNOWN
ATC: H03AA01
UNII: 9J765S329G

Structure
InChI Key ANMYAHDLKVNJJO-LTCKWSDVSA-M
Smile N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+]
InChI
InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m0../s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H12I4NNaO5
Molecular Weight 816.87
AlogP 4.56
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 5.0
Polar Surface Area 92.78
Molecular species ZWITTERION
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Thyroid hormone receptor agonist

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Congenital Hypothyroidism 4 D003409 ClinicalTrials
Bipolar Disorder 2 D001714 ClinicalTrials
Pain 1 D010146 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 6447
ChEMBL CHEMBL2103741
FDA SRS 9J765S329G
PubChem 23667619
SureChEMBL SCHEMBL2327406
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