MECLOFENAMIC ACID

Search structure
Synonyms:
Status: Approved (1980)
Entry Type: Small molecule
Molecule Category: Parent
ATC: M01AG04
UNII: 48I5LU4ZWD

Structure
InChI Key SBDNJUWAMKYJOX-UHFFFAOYSA-N
Smile Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl
InChI
InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H11Cl2NO2
Molecular Weight 296.15
AlogP 4.74
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 3.0
Polar Surface Area 49.33
Molecular species ACID
Aromatic Rings 2.0
Heavy Atoms 19.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Auxiliary transport protein Fatty acid binding protein family
- - - 256-379 -
Enzyme Oxidoreductase
- 100-100 - - -
Enzyme
- 100-100 - - -
Secreted protein
- 50000 480 - 97
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4
- - - - 43
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 27240 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 6710
ChEMBL CHEMBL509
DrugBank DB00939
DrugCentral 1650
EPA CompTox DTXSID0048559
FDA SRS 48I5LU4ZWD
Human Metabolome Database HMDB0015074
Guide to Pharmacology 7219
KEGG C07117
PDB JMS
PharmGKB PA450341
SureChEMBL SCHEMBL106
ZINC ZINC000000001655
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