SENICAPOC

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: TS6G201A6Q

Structure
InChI Key SCTZUZTYRMOMKT-UHFFFAOYSA-N
Smile NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H15F2NO
Molecular Weight 323.34
AlogP 3.78
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 43.09
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
BLOCKER Intermediate conductance calcium-activated potassium channel protein 4 blocker PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Calcium-activated potassium channel
- 6-11000 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Anemia, Sickle Cell 3 D000755 ClinicalTrials
Asthma 2 D001249 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials
Severe Acute Respiratory Syndrome 2 D045169 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL405821
DrugBank DB06280
EPA CompTox DTXSID60276906
FDA SRS TS6G201A6Q
Guide to Pharmacology 2331
SureChEMBL SCHEMBL1443805
ZINC ZINC000003816408
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