AZILSARTAN

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: F9NUX55P23

Structure
InChI Key KGSXMPPBFPAXLY-UHFFFAOYSA-N
Smile CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1
InChI
InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)

Physicochemical Descriptors

Property Name Value
Molecular Formula C25H20N4O5
Molecular Weight 456.46
AlogP 4.6
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 123.5
Molecular species ACID
Aromatic Rings 5.0
Heavy Atoms 34.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Type-1 angiotensin II receptor antagonist PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) Angiotensin receptor
- 420 - - 100

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Hypertension 3 D006973 ClinicalTrials
Diabetes Mellitus, Type 2 3 D003924 ClinicalTrials
Essential Hypertension 3 D000075222 ClinicalTrials
Diabetes Mellitus 2 D003920 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 68850
ChEMBL CHEMBL57242
EPA CompTox DTXSID70163712
FDA SRS F9NUX55P23
Guide to Pharmacology 6901
SureChEMBL SCHEMBL167538
ZINC ZINC000000598390
CONTENTS