DIMETHINDENE

Search structure
Synonyms:
Status: Approved
Entry Type: Small molecule
Molecule Category: UKNOWN
UNII: 661FH77Z3P

Structure
InChI Key MVMQESMQSYOVGV-UHFFFAOYSA-N
Smile CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1
InChI
InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H24N2
Molecular Weight 292.43
AlogP 4.15
Hydrogen Bond Acceptor 2.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 5.0
Polar Surface Area 16.13
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 22.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Histamine H1 receptor antagonist PubMed DOI PubMed PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- - - 191 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor
- - - 1 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

Scaffolds

Cross References

Resources Reference
ChEBI 135222
ChEMBL CHEMBL22108
DrugBank DB08801
DrugCentral 903
EPA CompTox DTXSID9022942
FDA SRS 661FH77Z3P
Human Metabolome Database HMDB0015691
Guide to Pharmacology 10101
SureChEMBL SCHEMBL18759
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