RAUWOLFIA SERPENTINA

Search structure
Synonyms:
Status: Approved (1954)
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: H192N84N1G

Structure
InChI Key GRTOGORTSDXSFK-XJTZBENFSA-N
Smile COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
InChI
InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Adrenergic receptor alpha antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2D Cytochrome P450 2D6
- - - 3.3-14 -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- - - 289 -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor
- - - 14.5 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Heart Diseases 3 D006331 ClinicalTrials
Cardiovascular Diseases 3 D002318 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL3559672
FDA SRS H192N84N1G
CONTENTS