| Synonyms: | |
| Status: | Phase 3 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| ATC: | B03XA05 |
| UNII: | X3O30D9YMX |
Structure
| InChI Key | YOZBGTLTNGAVFU-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C19H16N2O5 |
| Molecular Weight | 352.35 |
| AlogP | 2.86 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 5.0 |
| Polar Surface Area | 108.75 |
| Molecular species | ACID |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 26.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Hypoxia-inducible factor prolyl hydroxylase inhibitor | PubMed |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Enzyme
Oxidoreductase
|
- | 27-5740 | - | 1070 | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Renal Insufficiency, Chronic | 3 | D051436 | ClinicalTrials |
| Myelodysplastic Syndromes | 3 | D009190 | ClinicalTrials |
| ST Elevation Myocardial Infarction | 2 | D000072657 | ClinicalTrials |
| Kidney Diseases | 1 | D007674 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEBI | 132774 |
| ChEMBL | CHEMBL2338329 |
| DrugBank | DB04847 |
| DrugCentral | 5371 |
| EPA CompTox | DTXSID60230644 |
| FDA SRS | X3O30D9YMX |
| Guide to Pharmacology | 8454 |
| PDB | 8HO |
| SureChEMBL | SCHEMBL523705 |
| ZINC | ZINC000071257465 |
CONTENTS