GIREDESTRANT

Search structure
Synonyms:
Status: Phase 3
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 28P3DU6DB3

Structure
InChI Key GQCXHIKRWBIQMD-AKJBCIBTSA-N
Smile C[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(F)(F)CO
InChI
InChI=1S/C27H31F5N4O/c1-16-9-20-19-5-2-3-6-23(19)34-25(20)26(36(16)14-27(31,32)15-37)24-21(29)10-17(11-22(24)30)33-18-12-35(13-18)8-4-7-28/h2-3,5-6,10-11,16,18,26,33-34,37H,4,7-9,12-15H2,1H3/t16-,26-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C27H31F5N4O
Molecular Weight 522.56
AlogP 4.87
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 9.0
Polar Surface Area 54.53
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 37.0

Pharmacology

Action Mechanism of Action Reference
DEGRADER Estrogen receptor alpha degrader
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4
- 6500-26000 - - -
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 6100 - - -
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- - - - 15.7
Ion channel Voltage-gated ion channel Voltage-gated sodium channel
- - - - 16.7
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A Nuclear hormone receptor subfamily 3 group A member 1
- 0.05-0.43 - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Breast Neoplasms 3 D001943 ClinicalTrials
Endometrial Neoplasms 2 D016889 ClinicalTrials

Related Entries

Scaffolds

Cross References

Resources Reference
ChEMBL CHEMBL4650316
FDA SRS 28P3DU6DB3
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