| Synonyms: | |
| Status: | Phase 2 |
| Entry Type: | Small molecule |
| Molecule Category: | UNKNOWN |
| UNII: | KE63TTO7WK |
Structure
| InChI Key | JOPCJJSYRPUEDS-UHFFFAOYSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H22F4N4O |
| Molecular Weight | 446.45 |
| AlogP | 4.56 |
| Hydrogen Bond Acceptor | 4.0 |
| Hydrogen Bond Donor | 1.0 |
| Number of Rotational Bond | 6.0 |
| Polar Surface Area | 64.15 |
| Molecular species | BASE |
| Aromatic Rings | 3.0 |
| Heavy Atoms | 32.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| INHIBITOR | Fusion glycoprotein F0 inhibitor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Surface antigen
|
- | 0.9 | - | - | - |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Respiratory Syncytial Virus Infections | 2 | D018357 | ClinicalTrials |
| Liver Diseases | 1 | D008107 | ClinicalTrials |
Related Entries
Scaffolds
Cross References
| Resources | Reference |
|---|---|
| ChEMBL | CHEMBL4297497 |
| DrugBank | DB15674 |
| FDA SRS | KE63TTO7WK |
| PDB | WVA |
| SureChEMBL | SCHEMBL19470916 |
CONTENTS