BMS-984923

Search structure
Synonyms:
Status: Phase 1
Entry Type: Small molecule
Molecule Category: UNKNOWN
UNII: 3I1803DK5Z

Structure
InChI Key IAYVUQJOKDFLAL-NHCUHLMSSA-N
Smile O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2ccccc2Cl)O1
InChI
InChI=1S/C22H15ClN2O2/c23-19-9-5-4-8-18(19)21-20(25-22(26)27-21)17-12-16(13-24-14-17)11-10-15-6-2-1-3-7-15/h1-9,12-14,20-21H,(H,25,26)/t20-,21-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H15ClN2O2
Molecular Weight 374.83
AlogP 4.66
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 2.0
Polar Surface Area 51.22
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 27.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) Neurotransmitter receptor (family C GPCR) Metabotropic glutamate receptor
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Indications

Mesh Heading Maximum Phase Mesh ID Reference
Alzheimer Disease 1 D000544 ClinicalTrials

Cross References

Resources Reference
ChEMBL CHEMBL4571075
FDA SRS 3I1803DK5Z
SureChEMBL SCHEMBL4541143
CONTENTS