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DERMATOLOGY (31)
DIABETES DRUGS & ENDOCRINOLOGY (61)
EMERGENCY MEDICINE (3)
ENT (5)
EYE (23)
GASTROINTESTINAL (29)
HEMATOLOGY (23)
MUSCULOSKELETAL (28)
NEUROLOGY DRUGS & NERVOUS SYSTEM (50)
PEDIATRICS (27)
PHARMACOLOGY (8)
PREGNANCY AND GYNECOLOGY (30)
RESPIRATORY (42)
RHEUMATOLOGY (19)
OTHER (1482)
Therapeutic Indication
Adverse Reaction (System Organ Classification)
Mechanism of Action
Primary Target
Target Level
Level 1
Level 2
Level 3
Level 4
Level 5
Level 6
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Display Options:
Drug type
Therapeutic Area
Route of administration
Mechanism of Action
Indication
Status
Total:
6532
PLEVITREXED
2
Small molecule
Investigational
Unknown
Unknown
Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms
Unknown
PLEVITREXED
×
Maximum Phase:
2
First Approval:
None
UNII:
L9P2881C3H
Molecule Type:
Small molecule
Molecular Formula:
C26H25FN8O4
Molecular Weight:
532.54
AlogP:
2.06
PSA:
170.11
HBD:
4.0
HBA:
#RotB:
10.0
Source:
CC-401
2
Small molecule
Investigational
Unknown
Unknown
Leukemia, Myeloid
c-Jun N-terminal kinase 1 inhibitor
CC-401
×
Maximum Phase:
2
First Approval:
None
UNII:
NOE38VQA1W
Molecule Type:
Small molecule
Molecular Formula:
C22H24N6O
Molecular Weight:
388.48
AlogP:
3.88
PSA:
82.72
HBD:
2.0
HBA:
#RotB:
6.0
Source:
FORODESINE HCL
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
FORODESINE HCL
×
Maximum Phase:
2
First Approval:
None
UNII:
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
MGCD265
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
MGCD265
×
Maximum Phase:
2
First Approval:
None
UNII:
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
CAYSTON
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
CAYSTON
×
Maximum Phase:
2
First Approval:
None
UNII:
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
CP-601927
2
Small molecule
Investigational
Unknown
Unknown
Depressive Disorder, Major
Neuronal acetylcholine receptor; alpha4/beta2 partial agonist
CP-601927
×
Maximum Phase:
2
First Approval:
None
UNII:
VI5LR1EU47
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
CPI 613
2
Small molecule
Investigational
Unknown
Unknown
Biliary Tract Neoplasms; Sarcoma; Carcinoma, Pancreatic Ductal; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Neoplasms; Leukemia, Myeloid, Acute; Pancreatic Neoplasms
Unknown
CPI 613
×
Maximum Phase:
2
First Approval:
None
UNII:
E76113IR49
Molecule Type:
Small molecule
Molecular Formula:
C22H28O2S2
Molecular Weight:
388.6
AlogP:
6.26
PSA:
37.3
HBD:
1.0
HBA:
#RotB:
13.0
Source:
CHLORSULFAQUINOXALINE
2
Small molecule
Investigational
Unknown
Unknown
Colorectal Neoplasms; Lung Neoplasms
Unknown
CHLORSULFAQUINOXALINE
×
Maximum Phase:
2
First Approval:
None
UNII:
O0408QB48D
Molecule Type:
Small molecule
Molecular Formula:
C14H11ClN4O2S
Molecular Weight:
334.79
AlogP:
2.67
PSA:
97.97
HBD:
2.0
HBA:
#RotB:
3.0
Source:
APITOLISIB
2
Small molecule
Investigational
Unknown
Unknown
Lymphoma, Non-Hodgkin; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Carcinoma, Renal Cell; Endometrial Neoplasms
PI3-kinase class I inhibitor
APITOLISIB
×
Maximum Phase:
2
First Approval:
None
UNII:
1C854K1MIJ
Molecule Type:
Small molecule
Molecular Formula:
C23H30N8O3S
Molecular Weight:
498.61
AlogP:
0.9
PSA:
133.83
HBD:
2.0
HBA:
#RotB:
5.0
Source:
RO-24-7429
2
Small molecule
Investigational
Unknown
Unknown
HIV Infections
Human immunodeficiency virus type 1 Tat protein antagonist
RO-24-7429
×
Maximum Phase:
2
First Approval:
None
UNII:
MLW2GKK8LI
Molecule Type:
Small molecule
Molecular Formula:
C14H13ClN4
Molecular Weight:
272.74
AlogP:
2.77
PSA:
52.54
HBD:
2.0
HBA:
#RotB:
1.0
Source:
PRADEFOVIR
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
PRADEFOVIR
×
Maximum Phase:
2
First Approval:
None
UNII:
GZE85Q9Q61
Molecule Type:
Small molecule
Molecular Formula:
C17H19ClN5O4P
Molecular Weight:
423.8
AlogP:
3.41
PSA:
114.38
HBD:
1.0
HBA:
#RotB:
6.0
Source:
TALMAPIMOD
2
Small molecule
Investigational
Unknown
Unknown
Arthritis, Rheumatoid; Multiple Myeloma
MAP kinase p38 alpha inhibitor
TALMAPIMOD
×
Maximum Phase:
2
First Approval:
None
UNII:
B1E00KQ6NT
Molecule Type:
Small molecule
Molecular Formula:
C27H30ClFN4O3
Molecular Weight:
513.01
AlogP:
3.98
PSA:
65.86
HBD:
0.0
HBA:
#RotB:
5.0
Source:
SCH-900271
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Hydroxycarboxylic acid receptor 2 agonist
SCH-900271
×
Maximum Phase:
2
First Approval:
None
UNII:
G2283XQ6VJ
Molecule Type:
Small molecule
Molecular Formula:
C14H16N2O4
Molecular Weight:
276.29
AlogP:
1.29
PSA:
95.93
HBD:
2.0
HBA:
#RotB:
4.0
Source:
NAVEGLITAZAR
2
Small molecule
Investigational
Unknown
Unknown
Diabetes Mellitus, Type 2
Peroxisome proliferator-activated receptor alpha agonist
NAVEGLITAZAR
×
Maximum Phase:
2
First Approval:
None
UNII:
Y995M7GM0G
Molecule Type:
Small molecule
Molecular Formula:
C25H26O6
Molecular Weight:
422.48
AlogP:
4.97
PSA:
74.22
HBD:
1.0
HBA:
#RotB:
12.0
Source:
VARLITINIB
2
Small molecule
Investigational
Unknown
Unknown
Carcinoma, Hepatocellular; Neoplasms; Pancreatic Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Cholangiocarcinoma; Stomach Neoplasms
Epidermal growth factor receptor erbB1 inhibitor
VARLITINIB
×
Maximum Phase:
2
First Approval:
None
UNII:
846Y8197W1
Molecule Type:
Small molecule
Molecular Formula:
C22H19ClN6O2S
Molecular Weight:
466.95
AlogP:
5.25
PSA:
93.55
HBD:
2.0
HBA:
#RotB:
6.0
Source:
HYPOCHLOROUS ACID
2
Small molecule
Investigational
Unknown
Unknown
Diabetic Foot; Infections
Unknown
HYPOCHLOROUS ACID
×
Maximum Phase:
2
First Approval:
None
UNII:
712K4CDC10
Molecule Type:
Small molecule
Molecular Formula:
HClO
Molecular Weight:
52.46
AlogP:
0.13
PSA:
20.23
HBD:
1.0
HBA:
#RotB:
0.0
Source:
METHOXYVERAPAMIL
2
Small molecule
Investigational
Unknown
Unknown
Asthma
Unknown
METHOXYVERAPAMIL
×
Maximum Phase:
2
First Approval:
None
UNII:
None
Molecule Type:
Small molecule
Molecular Formula:
C26H36N2O3
Molecular Weight:
424.59
AlogP:
5.08
PSA:
54.72
HBD:
0.0
HBA:
#RotB:
12.0
Source:
MIRANSERTIB
2
Small molecule
Investigational
Unknown
Unknown
Endometrial Neoplasms; Lymphoma; Ovarian Neoplasms; Proteus Syndrome
Serine/threonine-protein kinase AKT inhibitor
MIRANSERTIB
×
Maximum Phase:
2
First Approval:
None
UNII:
T1DQI1B52Y
Molecule Type:
Small molecule
Molecular Formula:
C27H24N6
Molecular Weight:
432.53
AlogP:
5.07
PSA:
95.64
HBD:
2.0
HBA:
#RotB:
4.0
Source:
GLYCYRRHIZIN
2
Small molecule
Investigational
Unknown
Unknown
Renal Insufficiency, Chronic
Unknown
GLYCYRRHIZIN
×
Maximum Phase:
2
First Approval:
None
UNII:
6FO62043WK
Molecule Type:
Small molecule
Molecular Formula:
C42H62O16
Molecular Weight:
822.94
AlogP:
2.25
PSA:
267.04
HBD:
8.0
HBA:
#RotB:
7.0
Source:
AFELETECAN
2
Small molecule
Investigational
Unknown
Unknown
Unknown
DNA topoisomerase I stabiliser
AFELETECAN
×
Maximum Phase:
2
First Approval:
None
UNII:
IX0QAD6RD2
Molecule Type:
Small molecule
Molecular Formula:
C45H49N7O11S
Molecular Weight:
895.99
AlogP:
2.95
PSA:
237.48
HBD:
6.0
HBA:
#RotB:
13.0
Source:
BURAPITANT
2
Small molecule
Investigational
Unknown
Unknown
Urinary Bladder, Overactive
Neurokinin 1 receptor antagonist
BURAPITANT
×
Maximum Phase:
2
First Approval:
None
UNII:
E35SK332MS
Molecule Type:
Small molecule
Molecular Formula:
C31H35Cl2F6N3O3
Molecular Weight:
682.53
AlogP:
6.94
PSA:
75.87
HBD:
1.0
HBA:
#RotB:
8.0
Source:
AZD8871
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
AZD8871
×
Maximum Phase:
2
First Approval:
None
UNII:
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
DEUTARSERINE
2
Small molecule
Investigational
Unknown
Unknown
Schizophrenia
Unknown
DEUTARSERINE
×
Maximum Phase:
2
First Approval:
None
UNII:
None
Molecule Type:
Small molecule
Molecular Formula:
C3H7NO3
Molecular Weight:
106.1
AlogP:
-1.61
PSA:
83.55
HBD:
3.0
HBA:
#RotB:
2.0
Source:
APG115
2
Small molecule
Investigational
Unknown
Unknown
Leukemia, Myeloid, Acute; Liposarcoma; Lymphoma; Salivary Gland Neoplasms; Leukemia, Lymphoid
Tumour suppressor p53/oncoprotein Mdm2 inhibitor
APG115
×
Maximum Phase:
2
First Approval:
None
UNII:
15QAU0SI9J
Molecule Type:
Small molecule
Molecular Formula:
C34H38Cl2FN3O4
Molecular Weight:
642.6
AlogP:
6.81
PSA:
98.74
HBD:
3.0
HBA:
#RotB:
5.0
Source:
R-112
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Tyrosine-protein kinase SYK inhibitor
R-112
×
Maximum Phase:
2
First Approval:
None
UNII:
None
Molecule Type:
Small molecule
Molecular Formula:
Molecular Weight:
AlogP:
PSA:
HBD:
HBA:
#RotB:
Source:
ELTOPRAZINE
2
Small molecule
Investigational
Unknown
Unknown
Unknown
Unknown
ELTOPRAZINE
×
Maximum Phase:
2
First Approval:
None
UNII:
510M006KO6
Molecule Type:
Small molecule
Molecular Formula:
C12H16N2O2
Molecular Weight:
220.27
AlogP:
0.87
PSA:
33.73
HBD:
1.0
HBA:
#RotB:
1.0
Source:
AZD2066
2
Small molecule
Investigational
Unknown
Unknown
Chronic Pain; Gastroesophageal Reflux; Depressive Disorder, Major; Diabetic Neuropathies; Neuralgia; Pain
Metabotropic glutamate receptor 5 modulator
AZD2066
×
Maximum Phase:
2
First Approval:
None
UNII:
MQ908Y1ZB2
Molecule Type:
Small molecule
Molecular Formula:
C19H16ClN5O2
Molecular Weight:
381.82
AlogP:
4.33
PSA:
78.86
HBD:
0.0
HBA:
#RotB:
5.0
Source:
REVAMILAST
2
Small molecule
Investigational
Unknown
Unknown
Arthritis, Rheumatoid; Asthma
Unknown
REVAMILAST
×
Maximum Phase:
2
First Approval:
None
UNII:
30LE65637T
Molecule Type:
Small molecule
Molecular Formula:
C18H9Cl2F2N3O4
Molecular Weight:
440.19
AlogP:
4.77
PSA:
91.3
HBD:
1.0
HBA:
#RotB:
4.0
Source:
AFIMOXIFENE
2
Small molecule
Investigational
Unknown
Unknown
Carcinoma, Intraductal, Noninfiltrating; Mastodynia
Estrogen receptor modulator
AFIMOXIFENE
×
Maximum Phase:
2
First Approval:
None
UNII:
95K54647BZ
Molecule Type:
Small molecule
Molecular Formula:
C26H29NO2
Molecular Weight:
387.52
AlogP:
5.7
PSA:
32.7
HBD:
1.0
HBA:
#RotB:
8.0
Source:
DERENOFYLLINE
2
Small molecule
Investigational
Unknown
Unknown
Heart Failure
Adenosine A1 receptor antagonist
DERENOFYLLINE
×
Maximum Phase:
2
First Approval:
None
UNII:
O1Q96UZ63W
Molecule Type:
Small molecule
Molecular Formula:
C18H20N4O
Molecular Weight:
308.39
AlogP:
3.34
PSA:
73.83
HBD:
3.0
HBA:
#RotB:
3.0
Source:
GSK189254
2
Small molecule
Investigational
Unknown
Unknown
Narcolepsy
Histamine H3 receptor antagonist
GSK189254
×
Maximum Phase:
2
First Approval:
None
UNII:
5T4TX6CO53
Molecule Type:
Small molecule
Molecular Formula:
C21H25N3O2
Molecular Weight:
351.45
AlogP:
3.19
PSA:
54.46
HBD:
1.0
HBA:
#RotB:
4.0
Source:
ALAGEBRIUM CHLORIDE
2
Small molecule
Investigational
Unknown
Unknown
Cardiovascular Diseases; Heart Failure; Hypertension
Unknown
ALAGEBRIUM CHLORIDE
×
Maximum Phase:
2
First Approval:
None
UNII:
79QS8K2877
Molecule Type:
Small molecule
Molecular Formula:
C13H14ClNOS
Molecular Weight:
267.78
AlogP:
2.54
PSA:
20.95
HBD:
0.0
HBA:
#RotB:
3.0
Source:
FULACIMSTAT
2
Small molecule
Investigational
Unknown
Unknown
Diabetic Nephropathies; Heart Failure; Myocardial Infarction
Chymase inhibitor
FULACIMSTAT
×
Maximum Phase:
2
First Approval:
None
UNII:
VIR72PP4ZU
Molecule Type:
Small molecule
Molecular Formula:
C23H16F3N3O6
Molecular Weight:
487.39
AlogP:
2.7
PSA:
116.44
HBD:
1.0
HBA:
#RotB:
3.0
Source:
ACRIDINE
2
Small molecule
Investigational
Unknown
Unknown
Central Nervous System Neoplasms; Lung Neoplasms
DNA disrupting agent
ACRIDINE
×
Maximum Phase:
2
First Approval:
None
UNII:
42NI1P5Q1X
Molecule Type:
Small molecule
Molecular Formula:
C13H9N
Molecular Weight:
179.22
AlogP:
3.39
PSA:
12.89
HBD:
0.0
HBA:
#RotB:
0.0
Source:
SUTEZOLID
2
Small molecule
Investigational
Unknown
Unknown
Tuberculosis; Tuberculosis, Pulmonary
70S ribosome inhibitor
SUTEZOLID
×
Maximum Phase:
2
First Approval:
None
UNII:
3A71182L8P
Molecule Type:
Small molecule
Molecular Formula:
C16H20FN3O3S
Molecular Weight:
353.42
AlogP:
1.84
PSA:
61.88
HBD:
1.0
HBA:
#RotB:
4.0
Source:
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ALogP
PSA