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Total: 6532
Small molecule
Approved
Unknown
Unknown
Contracture; Peanut Hypersensitivity; Conjunctivitis, Allergic; Dyspepsia; Fibromyalgia; Rhinitis, Allergic, Perennial; Eye Manifestations; Hypersensitivity
Unknown
Small molecule
Approved
OTHER; PHARMACOLOGY
INJECTION
Unknown
Muscle-type nicotinic acetylcholine receptor antagonist
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PREGNANCY AND GYNECOLOGY
ORAL; VAGINAL
Atrophy; Menopause
Estrogen receptor agonist
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Anxiety; Dementia; Depressive Disorder; Schizophrenia; Sleep Initiation and Maintenance Disorders
GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator
Small molecule
Approved
IMMUNE SYSTEM; OTHER
ORAL
Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 protease inhibitor
Small molecule
Approved
Unknown
Unknown
Pain; Liver Diseases; Ileus; Retinopathy of Prematurity; Apnea; Premature Birth
Adenosine receptor antagonist
Small molecule
Approved
OTHER
ORAL
CADASIL; Fatty Liver; Osteoarthritis; Pain; Cerebral Small Vessel Diseases; Cognitive Dysfunction; Intermittent Claudication; Stroke; Atherosclerosis; Cardiovascular Diseases; Cerebral Infarction; Cerebrovascular Disorders; Coronary Disease; Peripheral Arterial Disease; Peripheral Vascular Diseases; Thrombosis
Phosphodiesterase 3A inhibitor
Small molecule
Approved
Unknown
Unknown
Aortic Aneurysm, Abdominal; Asthma; Muscular Dystrophy, Duchenne
Unknown
Small molecule
Approved
Unknown
Unknown
Brain Ischemia; Radius Fractures; Renal Insufficiency; Vascular Diseases; Alzheimer Disease; Brain Injuries; Chronic Pain; Cocaine-Related Disorders; Cognitive Dysfunction; Cough; Epilepsy; Heart Diseases; Postoperative Complications; Pregnancy; Scoliosis; Sleep Initiation and Maintenance Disorders; Acute Kidney Injury; Amyotrophic Lateral Sclerosis; Brain Neoplasms; Burns; Child Development Disorders, Pervasive; Coronary Disease; Hernias, Diaphragmatic, Congenital; Hypertension, Pulmonary; Hypertrophy; Mental Disorders; Pheochromocytoma; Pre-Eclampsia; Shoulder Pain; Temporomandibular Joint Disorders; Wounds and Injuries; Anxiety; Brain Diseases; Breast Neoplasms; Cleft Palate; Delirium; Digestive System Diseases; Fractures, Bone; Headache; Heart Septal Defects, Atrial; Hypertension; Inflammation; Neoplasms; Obesity; Obesity, Morbid; Opioid-Related Disorders; Pain; Pharyngitis; Postoperative Nausea and Vomiting; Psychomotor Agitation; Respiratory Insufficiency; Rib Fractures; Shock, Septic; Sleep Apnea, Obstructive; Stomach Neoplasms; Subarachnoid Hemorrhage; Tremor
Unknown
Small molecule
Approved
HEMATOLOGY
ORAL
Cognitive Dysfunction; HIV Infections; Amyotrophic Lateral Sclerosis; beta-Thalassemia; Dementia; Friedreich Ataxia; Parkinson Disease; Acute Kidney Injury; Hemochromatosis; Pantothenate Kinase-Associated Neurodegeneration; Anemia, Sickle Cell; Thalassemia
Unknown
Small molecule
Approved
Unknown
Unknown
Osteomyelitis
Bacterial 70S ribosome inhibitor
Small molecule
Approved
OTHER; RESPIRATORY
ORAL
Long QT Syndrome; Heart Failure; Arrhythmias, Cardiac; Atrial Fibrillation
HERG blocker
Small molecule
Approved
Unknown
Unknown
Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Hodgkin Disease; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Testicular Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Inflammatory Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Nasopharyngeal Neoplasms; Stomach Neoplasms; Thrombosis; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Neoplasms
Unknown
Small molecule
Unknown
Unknown
Unknown
Esophagitis, Peptic; Laryngopharyngeal Reflux; Cerebrovascular Disorders; Duodenal Ulcer; Gastroesophageal Reflux; Zollinger-Ellison Syndrome
Potassium-transporting ATPase inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY
INJECTION; ORAL
Neoplasms; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Hyperparathyroidism, Secondary; Parathyroid Diseases; Renal Insufficiency, Chronic
Vitamin D receptor agonist
Small molecule
Approved
Unknown
Unknown
Barrett Esophagus; Gingivitis; Adrenoleukodystrophy; Anemia, Sickle Cell; Burns; Carcinoma in Situ; Carcinoma, Intraductal, Noninfiltrating; Glioblastoma; Hyperlipidemias; Irritable Bowel Syndrome; Papilloma; Pneumonia; Sarcopenia; Skin Neoplasms; Tibial Fractures; Acquired Immunodeficiency Syndrome; Aging; Autistic Disorder; Bronchiolitis; Colonic Neoplasms; Common Cold; Conjunctivitis, Allergic; Depressive Disorder; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 1; Glucose Intolerance; Hematologic Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Hypersensitivity; Infertility, Male; Keratosis, Actinic; Leukemia, Myeloid, Acute; Lupus Erythematosus, Systemic; Malnutrition; Metabolic Syndrome; Multiple Sclerosis; Neoplasms; Neurofibromatosis 1; Optic Neuritis; Ovarian Neoplasms; Parkinson Disease; Prediabetic State; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Respiratory Insufficiency; Staphylococcal Infections; Urinary Tract Infections; Adenoma; Arthritis, Juvenile; Asthma; Bone Diseases, Metabolic; Breast Neoplasms; Cardiovascular Diseases; Cognitive Dysfunction; Colitis, Ulcerative; Colorectal Neoplasms; Crohn Disease; Diabetes, Gestational; Diabetes Mellitus, Type 2; Epilepsy; Fractures, Bone; Heart Failure; Helicobacter Infections; Hepatitis C; Hip Fractures; HIV Infections; Hyperparathyroidism; Hypogonadism; Infections; Influenza, Human; Leukemia, Lymphocytic, Chronic, B-Cell; Lipid Metabolism Disorders; Melanoma; Multiple Sclerosis, Relapsing-Remitting; Non-alcoholic Fatty Liver Disease; Obesity; Osteitis Deformans; Osteoporosis, Postmenopausal; Polycystic Ovary Syndrome; Pregnancy; Prostatic Neoplasms; Renal Insufficiency, Chronic; Schizophrenia; Severe Acute Respiratory Syndrome; Tuberculosis; Tuberculosis, Pulmonary; Urticaria; Vitamin D Deficiency; Anemia; Anemia, Iron-Deficiency; Osteoporosis
Vitamin D receptor agonist
Small molecule
Approved
CANCER; OTHER
INTRAVENOUS; ORAL
Desmoplastic Small Round Cell Tumor; Cytomegalovirus Infections; Ependymoma; Fallopian Tube Neoplasms; Meningitis, Aseptic; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Biliary Tract Neoplasms; Brain Diseases; Brain Stem Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Colorectal Neoplasms; Ganglioneuroblastoma; Gastrointestinal Stromal Tumors; Glioma; Hereditary Breast and Ovarian Cancer Syndrome; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Medulloblastoma; Myelodysplastic Syndromes; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neurofibromatosis 1; Ovarian Neoplasms; Pancreatic Neoplasms; Pinealoma; Pituitary Neoplasms; Rectal Neoplasms; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Spinal Cord Neoplasms; Astrocytoma; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Diffuse Intrinsic Pontine Glioma; Gliosarcoma; Melanoma; Neoplasm Metastasis; Neuroendocrine Tumors; Oligodendroglioma; Optic Nerve Glioma; Sarcoma, Ewing; Glioblastoma; Neoplasms
DNA inhibitor
Small molecule
Approved
IMMUNE SYSTEM
TOPICAL
Breast Neoplasms; Lichen Planus; Lupus Erythematosus, Cutaneous; Psoriasis; Hand Dermatoses; Eczema; Neoplasms
Retinoid receptor agonist
Small molecule
Approved
MUSCULOSKELETAL; OTHER; RHEUMATOLOGY
ORAL
Brain Neoplasms; Glioma; Alzheimer Disease; Carcinoma, Non-Small-Cell Lung; Adenoma; Colorectal Neoplasms; Joint Diseases; Osteoarthritis; Osteoarthritis, Knee; Pain; Prostatic Neoplasms, Castration-Resistant; Stomach Neoplasms; Rheumatic Diseases
Cyclooxygenase-2 inhibitor
Small molecule
Approved
OTHER
ORAL; TOPICAL
Thyroid Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Multiple Myeloma; Pituitary ACTH Hypersecretion; Alopecia Areata; Alzheimer Disease; Breast Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lung Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Myelodysplastic Syndromes; Parapsoriasis; Psoriasis; Sezary Syndrome; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lymphoma, Large-Cell, Anaplastic; Mycosis Fungoides; Psychotic Disorders; Schizophrenia; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Neoplasms
Retinoid X receptor agonist
Small molecule
Approved
Unknown
Unknown
Acne Vulgaris; Astrocytoma; Colonic Neoplasms; Crohn Disease; Gliosarcoma; Oligodendroglioma; Basal Cell Nevus Syndrome; Brain Neoplasms; Carcinoma, Basal Cell; Fibromatosis, Aggressive; Glioblastoma; Neurofibromatosis 1; Glioma; Infections; Keratosis, Actinic; Neoplasms
Unknown
Small molecule
Approved
IMMUNE SYSTEM; OTHER; UROLOGY AND KIDNEY
ORAL
Pemphigus; Acute Lung Injury; Adenocarcinoma of Lung; Alcoholism; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Diabetic Retinopathy; Fallopian Tube Neoplasms; Fibromatosis, Aggressive; Frontotemporal Dementia; Gangliosidoses; Gaucher Disease; Glioblastoma; Glycogen Storage Disease Type II; Granulomatous Disease, Chronic; Hematologic Neoplasms; HIV Infections; Hypercholesterolemia; Hyperinsulinism; Hypertension, Pulmonary; Kidney Diseases; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Plasma Cell; Lung Neoplasms; Multiple Sclerosis, Relapsing-Remitting; Neoplasm Metastasis; Neurilemmoma; Pachyonychia Congenita; Parkinson Disease; Port-Wine Stain; Prostatic Neoplasms; Rectal Neoplasms; Respiratory Distress Syndrome; Sarcopenia; Scleritis; Small Cell Lung Carcinoma; Uveitis, Anterior; Adenomatous Polyposis Coli; Aging; Amyotrophic Lateral Sclerosis; Anemia; Anemia, Aplastic; Anemia, Sickle Cell; beta-Thalassemia; Bronchitis; Carcinoma, Renal Cell; Castleman Disease; Depressive Disorder; Dry Eye Syndromes; Fanconi Anemia; Gliosarcoma; Glomerulonephritis, IGA; Glomerulosclerosis, Focal Segmental; Graves Ophthalmopathy; Hematologic Diseases; Hypertension; Intracranial Aneurysm; Intracranial Arteriovenous Malformations; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Liver Neoplasms; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Cutaneous; Macular Degeneration; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neurofibromatosis 1; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Pinealoma; Polycystic Kidney Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Renal Insufficiency; Retroperitoneal Fibrosis; Sarcoma; Scleroderma, Systemic; Severe Acute Respiratory Syndrome; Severe Combined Immunodeficiency; Sturge-Weber Syndrome; Thyroid Neoplasms; Uveitis, Intermediate; Uveitis, Posterior; Vascular Malformations; Wet Macular Degeneration; Birt-Hogg-Dube Syndrome; Breast Neoplasms; Carcinoma, Hepatocellular; Cardiovascular Abnormalities; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Fibroma; Graft vs Host Disease; Hodgkin Disease; Lichen Planus, Oral; Lymphangioleiomyomatosis; Lymphoma, Non-Hodgkin; Myositis, Inclusion Body; Polycystic Kidney, Autosomal Dominant; Renal Insufficiency, Chronic; Skin Neoplasms; Urinary Bladder Neoplasms; Eye Diseases; Immune System Diseases
FK506-binding protein 1A inhibitor
Small molecule
Approved
Unknown
Unknown
Obesity; Renal Insufficiency, Chronic; Infections; Influenza in Birds; Thrombocytopenia; Influenza, Human; Purpura, Thrombocytopenic, Idiopathic; Severe Acute Respiratory Syndrome; Virus Diseases
Unknown
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Acquired Immunodeficiency Syndrome; Acute Coronary Syndrome; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Anemia; Arthritis, Rheumatoid; Asthma; Carcinoma, Renal Cell; Cardiotoxicity; Constipation; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyspepsia; Epilepsy; Erectile Dysfunction; Fibromyalgia; Heart Failure; Hepatitis C; HIV Infections; Hypertension; Hypoglycemia; Hypotension, Orthostatic; Immune System Diseases; Influenza, Human; Lice Infestations; Lipid Metabolism Disorders; Lung Diseases; Lupus Erythematosus, Systemic; Lymphoma; Malaria, Vivax; Nausea; Pain; Phenylketonurias; Premature Birth; Psychotic Disorders; Respiratory Tract Infections; Restless Legs Syndrome; Schizophrenia; Cholangitis; Meningitis; Muscle Spasticity; Neoplasms; Parkinson Disease; Tuberculosis, Multidrug-Resistant; Abscess; Breast Neoplasms; Bronchitis, Chronic; Cataract; Cellulitis; Cholecystitis, Acute; Conjunctivitis, Bacterial; Endophthalmitis; Infections; Inflammation; Otitis Externa; Otitis Media; Pelvic Inflammatory Disease; Pneumonia; Pneumonia, Bacterial; Pulmonary Disease, Chronic Obstructive; Sinusitis; Skin Diseases; Tuberculosis; Tuberculosis, Pulmonary; Bacterial Infections; Eye Infections
Unknown
Small molecule
Approved
Unknown
Unknown
Abdominal Pain; Cleft Palate; Postoperative Complications; Back Pain; Neoplasms; Pain; Pregnancy
Unknown
Small molecule
Approved
IMMUNE SYSTEM; OTHER
ORAL
Virus Diseases; Influenza, Human; Kidney Failure, Chronic
Neuraminidase inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
HIV Infections; Central Nervous System Neoplasms; Head and Neck Neoplasms; Heart Failure; Leukoplakia, Oral; Non-alcoholic Fatty Liver Disease; Pituitary ACTH Hypersecretion; Sarcoma; Atherosclerosis; Insulin Resistance; Diabetes Mellitus; Diabetes Mellitus, Type 2
Peroxisome proliferator-activated receptor gamma agonist
Small molecule
Unknown
Unknown
Unknown
Pain; Pregnancy
Sodium channel protein type IV alpha subunit blocker
Small molecule
Approved
Unknown
Unknown
Osteomyelitis
Bacterial 70S ribosome inhibitor
Small molecule
Approved
EYE; OTHER
OPHTHALMIC
Chronic Pain; Conjunctivitis, Allergic; Dermatitis; Dermatitis, Atopic; Fractures, Bone; Rhinitis, Allergic, Perennial
Histamine H1 receptor antagonist
Small molecule
Approved
OTHER
ORAL
Metabolic Syndrome; Hyperlipoproteinemia Type I; Polycystic Ovary Syndrome; Infertility; Obesity
Gastric lipase inhibitor
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Amphetamine-Related Disorders; Gastrointestinal Stromal Tumors; Epilepsy; Obesity; Cocaine-Related Disorders; Parkinson Disease
Catechol O-methyltransferase inhibitor
Small molecule
Unknown
Unknown
Unknown
Lymphoma; Breast Carcinoma In Situ; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms, Male; Carcinoma, Intraductal, Noninfiltrating; Breast Neoplasms; Neoplasms
Cytochrome P450 19A1 inhibitor
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown