BETAMETHASONE SODIUM PHOSPHATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1965)
Entry Type: Small molecule
Molecule Category: Salt Prodrug
UNII: 7BK02SCL3W
Parent Compound: BETAMETHASONE

Structure
InChI Key PLCQGRYPOISRTQ-LWCNAHDDSA-L
Smile C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
InChI
InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H28FNa2O8P
Molecular Weight 516.41
AlogP 2.01
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 4.0
Polar Surface Area 141.36
Molecular species ACID
Aromatic Rings 0.0
Heavy Atoms 32.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist ISBN

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Periarthritis 3 D010489 ClinicalTrials
Tendinopathy 3 D052256 ClinicalTrials
Osteoarthritis 3 D010003 ClinicalTrials
Dry Eye Syndromes 2 D015352 ClinicalTrials
Low Back Pain 0 D017116 ClinicalTrials

Related Entries

Scaffolds

Parent
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Injury, poisoning and procedural complications
25.0
Psychiatric disorders
25.0
Endocrine disorders
12.5
Metabolism and nutrition disorders
12.5
Nervous system disorders
12.5
Vascular disorders
12.5

Cross References

Resources Reference
ChEBI 3078
ChEMBL CHEMBL1200762
EPA CompTox DTXSID8047137
FDA SRS 7BK02SCL3W
PubChem 65478
SureChEMBL SCHEMBL8418
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