| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1961) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent |
| ATC: | A07EA04 |
| UNII: | 9842X06Q6M |
Structure
| InChI Key | UREBDLICKHMUKA-DVTGEIKXSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.47 |
| AlogP | 1.9 |
| Hydrogen Bond Acceptor | 5.0 |
| Hydrogen Bond Donor | 3.0 |
| Number of Rotational Bond | 2.0 |
| Polar Surface Area | 94.83 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 28.0 |
Pharmacology
| Primary Target | |
|---|---|
| Glucocorticoid receptor |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 103 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Pharyngitis | 3 | D010612 | ClinicalTrials |
| Premature Birth | 3 | D047928 | ClinicalTrials |
| Psoriasis | 3 | D011565 | ClinicalTrials |
| Cough | 3 | D003371 | ClinicalTrials |
| Pregnancy | 3 | D011247 | ClinicalTrials |
| Hypersensitivity | 3 | D006967 | ClinicalTrials |
| Carpal Tunnel Syndrome | 3 | D002349 | ClinicalTrials |
| Respiratory Distress Syndrome | 3 | D012128 | ClinicalTrials |
| Rhinitis, Allergic, Seasonal | 3 | D006255 | ClinicalTrials |
| Eczema | 3 | D004485 | ClinicalTrials |
| Lichen Planus, Oral | 3 | D017676 | ClinicalTrials |
| Psoriasis | 3 | D011565 | ClinicalTrials |
| Dry Eye Syndromes | 2 | D015352 | ClinicalTrials |
| Glaucoma | 2 | D005901 | ClinicalTrials |
| Respiratory Distress Syndrome, Newborn | 2 | D012127 | ClinicalTrials |
| Retinal Vein Occlusion | 2 | D012170 | ClinicalTrials |
| Melanoma | 2 | D008545 | ClinicalTrials |
| Sciatica | 2 | D012585 | ClinicalTrials |
| Bronchiolitis | 2 | D001988 | ClinicalTrials |
| Neck Pain | 2 | D019547 | ClinicalTrials |
| Macular Edema | 2 | D008269 | ClinicalTrials |
| Dermatitis, Atopic | 2 | D003876 | ClinicalTrials |
| Tachypnea | 2 | D059246 | ClinicalTrials |
| Adenoma | 1 | D000236 | ClinicalTrials |
| Hypospadias | 0 | D007021 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 378-44-9 |
| ChEBI | 3077 |
| ChEMBL | CHEMBL632 |
| DrugBank | DB00443 |
| DrugCentral | 348 |
| EPA CompTox | DTXSID3022667 |
| FDA SRS | 9842X06Q6M |
| Human Metabolome Database | HMDB0014586 |
| Guide to Pharmacology | 7061 |
| PharmGKB | PA164754818 |
| PubChem | 9782 |
| SureChEMBL | SCHEMBL4565 |
| ZINC | ZINC000003876136 |
CONTENTS