CHLORAMPHENICOL SODIUM SUCCINATE

Search structure
Trade Names:
Synonyms:
Status: Approved (1959)
Entry Type: Small molecule
Molecule Category: Salt Prodrug
UNII: 872109HX6B
Parent Compound: CHLORAMPHENICOL

Structure
InChI Key RPLOPBHEZLFENN-HTMVYDOJSA-M
Smile O=C([O-])CCC(=O)OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc([N+](=O)[O-])cc1.[Na+]
InChI
InChI=1S/C15H16Cl2N2O8.Na/c16-14(17)15(24)18-10(7-27-12(22)6-5-11(20)21)13(23)8-1-3-9(4-2-8)19(25)26;/h1-4,10,13-14,23H,5-7H2,(H,18,24)(H,20,21);/q;+1/p-1/t10-,13-;/m1./s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C15H15Cl2N2NaO8
Molecular Weight 445.19
AlogP 1.32
Hydrogen Bond Acceptor 7.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 10.0
Polar Surface Area 156.07
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
INHIBITOR Bacterial 70S ribosome inhibitor PubMed PubMed Wikipedia

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Osteomyelitis 0 D010019 ClinicalTrials

Related Entries

Parent

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Cardiac disorders
13.46
Injury, poisoning and procedural complications
10.58
Investigations
9.62
Nervous system disorders
9.62
Vascular disorders
8.65
General disorders and administration site conditions
7.69
Respiratory, thoracic and mediastinal disorders
6.73
Metabolism and nutrition disorders
5.77
Blood and lymphatic system disorders
3.85
Eye disorders
3.85
Pregnancy, puerperium and perinatal conditions
3.85
Skin and subcutaneous tissue disorders
3.85
Hepatobiliary disorders
2.88
Immune system disorders
2.88
Psychiatric disorders
2.88

Cross References

Resources Reference
ChEMBL CHEMBL1200729
EPA CompTox DTXSID2024747
FDA SRS 872109HX6B
KEGG C13962
PubChem 656833
SureChEMBL SCHEMBL193134
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