FLUOROMETHOLONE

Search structure
Trade Names:
Synonyms:
Status: Approved (1972)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C05AA06
UNII: SV0CSG527L

Structure
InChI Key FAOZLTXFLGPHNG-KNAQIMQKSA-N
Smile CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
InChI
InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C22H29FO4
Molecular Weight 376.47
AlogP 2.92
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 1.0
Polar Surface Area 74.6
Molecular species NEUTRAL
Aromatic Rings 0.0
Heavy Atoms 27.0

Pharmacology

Action Mechanism of Action Reference
AGONIST Glucocorticoid receptor agonist PubMed PubMed PubMed
Primary Target
Glucocorticoid receptor
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2
1300-12600 - - - -
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 106

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Dry Eye Syndromes 3 D015352 ClinicalTrials
Corneal Opacity 2 D003318 ClinicalTrials

Related Entries

Scaffolds

Salt
Mixture

Adverse Reactions

SOC By Demographic Distribution
System Organ Classification (SOC)
Relative Frequency (%)
Eye disorders
35.71
Injury, poisoning and procedural complications
14.7
General disorders and administration site conditions
9.48
Nervous system disorders
8.38
Skin and subcutaneous tissue disorders
8.1
Product issues
6.46
Psychiatric disorders
3.71
Gastrointestinal disorders
3.16
Immune system disorders
2.34

Cross References

Resources Reference
CAS NUMBER 426-13-1
ChEBI 31625
ChEMBL CHEMBL1200600
DrugBank DB00324
DrugCentral 1208
EPA CompTox DTXSID7047435
FDA SRS SV0CSG527L
Human Metabolome Database HMDB0014469
Guide to Pharmacology 7079
PharmGKB PA164781355
PubChem 9878
SureChEMBL SCHEMBL5051
ZINC ZINC000118912517
CONTENTS