LINCOMYCIN HYDROCHLORIDE

Search structure


Trade Names:	LINCOCIN LINCOMYCIN LINCOMYCIN HCL LINCOMYCIN HYDROCHLORIDE
Synonyms:	ALBIOTIC LINCOCIN LINCOLNENSIN HYDROCHLORIDE LINCOLNENSIN HYDROCHLORIDE MONOHYDRATE LINCOMIX LINCOMYCIN (AS HYDROCHLORIDE) LINCOMYCIN HCL LINCOMYCIN HYDROCHLORIDE ANHDROUS LINCOMYCIN HYDROCHLORIDE HYDRATE LINCOMYCIN HYDROCHLORIDE MONOHYDRATE LINCOMYCIN HYDROCHLORIDE USP NSC-70731 NSC-757092
Status:	Approved (1964)
Entry Type:	Small molecule
Molecule Category:	Salt
UNII:	M6T05Z2B68
Parent Compound:	LINCOMYCIN

Structure


InChI Key	POUMFISTNHIPTI-BOMBIWCESA-N
Smile	CCC[C@@H]1C[C@@H](C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)N(C)C1.Cl
InChI	InChI=1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H37ClN2O7S
Molecular Weight	461.02
AlogP	-0.86
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	7.0
Polar Surface Area	122.49
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	27.0

Pharmacology

Action	Mechanism of Action	Reference
INHIBITOR	70S ribosome inhibitor

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Transferase	-	-	-	-	17.86
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb	-	-	-	-	-15.32-3.89
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	83.01

Indications

Mesh Heading	Maximum Phase	Mesh ID	Reference
Osteomyelitis	1	D010019	ClinicalTrials

Related Entries

Scaffolds

Target Level :

Level 3

Level 4

Level 5

Level 6

Extend network:

Indication

Mechanism of Action

Primary Target

Target Level

Parent

Adverse Reactions

SOC By Demographic Distribution

System Organ Classification (SOC)

	Relative Frequency (%)
Immune system disorders	26.65
Gastrointestinal disorders	12.03
Skin and subcutaneous tissue disorders	11.75
Infections and infestations	6.59
General disorders and administration site conditions	6.3
Nervous system disorders	5.44
Injury, poisoning and procedural complications	4.87
Vascular disorders	4.3
Cardiac disorders	3.72
Respiratory, thoracic and mediastinal disorders	3.44
Metabolism and nutrition disorders	2.58
Renal and urinary disorders	2.29

Cross References

Resources	Reference
ChEBI	6472
ChEMBL	CHEMBL3989551
FDA SRS	M6T05Z2B68
KEGG	C14002
PubChem	71476
SureChEMBL	SCHEMBL192963
ZINC	ZINC03982483

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