| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1955) |
| Entry Type: | Small molecule |
| Molecule Category: | Parent Metabolite |
| ATC: | A07EA01 |
| UNII: | 9PHQ9Y1OLM |
Structure
| InChI Key | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value | |
|---|---|---|
| Molecular Formula | C21H28O5 | |
| Molecular Weight | 360.45 | |
| AlogP | 1.56 | |
| Hydrogen Bond Acceptor | 5.0 | |
| Hydrogen Bond Donor | 3.0 | |
| Number of Rotational Bond | 2.0 | |
| Polar Surface Area | 94.83 | |
| Molecular species | NEUTRAL | |
| Aromatic Rings | 0.0 | |
| Heavy Atoms | 26.0 |
Pharmacology
| Primary Target | |
|---|---|
| Glucocorticoid receptor |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference | ||
|---|---|---|---|---|---|
| Lupus Erythematosus, Systemic | 4 | D008180 | ClinicalTrials | ||
| Tennis Elbow | 4 | D013716 | ClinicalTrials | ||
| Spondylitis, Ankylosing | 4 | D013167 | ClinicalTrials | ||
| Rhinitis, Allergic, Seasonal | 4 | D006255 | ClinicalTrials | ||
| Arthritis, Psoriatic | 4 | D015535 | ClinicalTrials | ||
| Hypereosinophilic Syndrome | 3 | D017681 | ClinicalTrials | ||
| Spasms, Infantile | 3 | D013036 | ClinicalTrials | ||
| Multiple Myeloma | 3 | D009101 | ClinicalTrials | ||
| Pulmonary Disease, Chronic Obstructive | 3 | D029424 | ClinicalTrials | ||
| Biliary Atresia | 3 | D001656 | ClinicalTrials | ||
| Cataract | 3 | D002386 | ClinicalTrials | ||
| Glomerulonephritis, IGA | 3 | D005922 | ClinicalTrials | ||
| Pulpitis | 3 | D011671 | ClinicalTrials | ||
| Idiopathic Pulmonary Fibrosis | 3 | D054990 | ClinicalTrials | ||
| Hepatitis, Alcoholic | 3 | D006519 | ClinicalTrials | ||
| Pericarditis | 3 | D010493 | ClinicalTrials | ||
| Lymphoma, Follicular | 3 | D008224 | ClinicalTrials | ||
| Carcinoma, Hepatocellular | 3 | D006528 | ClinicalTrials | ||
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials | ||
| Lymphoma, Large B-Cell, Diffuse | 3 | D016403 | ClinicalTrials | ||
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials | ||
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials | ||
| Kidney Diseases | 3 | D007674 | ClinicalTrials | ||
| Hypersensitivity | 3 | D006967 | ClinicalTrials | ||
| Lymphoma, Non-Hodgkin | 3 | D008228 | ClinicalTrials | ||
| Purpura, Thrombocytopenic, Idiopathic | 3 | D016553 | ClinicalTrials | ||
| Churg-Strauss Syndrome | 3 | D015267 | ClinicalTrials | ||
| Croup | 3 | D003440 | ClinicalTrials | ||
| Vestibular Neuronitis | 3 | D020338 | ClinicalTrials | ||
| Anemia, Hemolytic, Autoimmune | 3 | D000744 | ClinicalTrials | ||
| Eczema | 3 | D004485 | ClinicalTrials | ||
| Headache | 3 | D006261 | ClinicalTrials | ||
| Inflammation | 3 | D007249 | ClinicalTrials | ||
| Glaucoma | 3 | D005901 | ClinicalTrials | ||
| Glomerulonephritis, Membranous | 3 | D015433 | ClinicalTrials | ||
| Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | 3 | D056648 | ClinicalTrials | ||
| Polymyalgia Rheumatica | 3 | D011111 | ClinicalTrials | ||
| Abortion, Habitual | 3 | D000026 | ClinicalTrials | ||
| Orbital Pseudotumor | 3 | D016727 | ClinicalTrials | ||
| Leukemia, Biphenotypic, Acute | 3 | D015456 | ClinicalTrials | ||
| Glaucoma, Open-Angle | 3 | D005902 | ClinicalTrials | ||
| Graves Disease | 3 | D006111 | ClinicalTrials | ||
| Ocular Hypertension | 3 | D009798 | ClinicalTrials | ||
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials | ||
| Red-Cell Aplasia, Pure | 3 | D012010 | ClinicalTrials | ||
| Glomerulonephritis | 3 | D005921 | ClinicalTrials | ||
| Prostatic Neoplasms, Castration-Resistant | 3 | D064129 | ClinicalTrials | ||
| Lymphoma, Follicular | 3 | D008224 | ClinicalTrials | ||
| Glomerulosclerosis, Focal Segmental | 3 | D005923 | ClinicalTrials | ||
| Adrenal Insufficiency | 3 | D000309 | ClinicalTrials | ||
| Pemphigus | 3 | D010392 | ClinicalTrials | ||
| Eye Infections | 3 | D015817 | ClinicalTrials | ||
| Sarcoma | 3 | D012509 | ClinicalTrials | ||
| Ischemic Stroke | 3 | D000083242 | ClinicalTrials | ||
| Endocardial Cushion Defects | 3 | D004694 | ClinicalTrials | ||
| Severe Acute Respiratory Syndrome | 3 | D045169 | ClinicalTrials | ||
| Prostatic Neoplasms | 3 | D011471 | ClinicalTrials | ||
| Precursor Cell Lymphoblastic Leukemia-Lymphoma | 3 | D054198 | ClinicalTrials | ||
| Mucocutaneous Lymph Node Syndrome | 3 | D009080 | ClinicalTrials | ||
| Lupus Nephritis | 3 | D008181 | ClinicalTrials | ||
| Diabetes Mellitus, Type 2 | 2 | D003924 | ClinicalTrials | ||
| Breast Neoplasms | 2 | D001943 | ClinicalTrials | ||
| Lichen Planus | 2 | D008010 | ClinicalTrials | ||
| Muscular Dystrophy, Duchenne | 2 | D020388 | ClinicalTrials | ||
| Giant Cell Arteritis | 2 | D013700 | ClinicalTrials | ||
| Schizophrenia | 2 | D012559 | ClinicalTrials | ||
| Renal Insufficiency, Chronic | 2 | D051436 | ClinicalTrials | ||
| Granulomatosis with Polyangiitis | 2 | D014890 | ClinicalTrials | ||
| Melanoma | 2 | D008545 | ClinicalTrials | ||
| Infertility | 2 | D007246 | ClinicalTrials | ||
| Aspergillosis, Allergic Bronchopulmonary | 2 | D001229 | ClinicalTrials | ||
| Immunoblastic Lymphadenopathy | 2 | D007119 | ClinicalTrials | ||
| Colitis | 2 | D003092 | ClinicalTrials | ||
| Lymphoma, T-Cell, Peripheral | 2 | D016411 | ClinicalTrials | ||
| Microscopic Polyangiitis | 2 | D055953 | ClinicalTrials | ||
| Pituitary ACTH Hypersecretion | 2 | D047748 | ClinicalTrials | ||
| Hodgkin Disease | 2 | D006689 | ClinicalTrials | ||
| Alveolitis, Extrinsic Allergic | 2 | D000542 | ClinicalTrials | ||
| Lymphoma, Large-Cell, Anaplastic | 2 | D017728 | ClinicalTrials | ||
| Hemangioma | 2 | D006391 | ClinicalTrials | ||
| Stomatitis, Aphthous | 2 | D013281 | ClinicalTrials | ||
| Uveitis | 2 | D014605 | ClinicalTrials | ||
| Hyperlipoproteinemia Type I | 2 | D008072 | ClinicalTrials | ||
| Celiac Disease | 2 | D002446 | ClinicalTrials | ||
| HIV Infections | 2 | D015658 | ClinicalTrials | ||
| Scleroderma, Systemic | 2 | D012595 | ClinicalTrials | ||
| Leprosy | 2 | D007918 | ClinicalTrials | ||
| Pemphigoid, Benign Mucous Membrane | 2 | D010390 | ClinicalTrials | ||
| Lipoma | 1 | D008067 | ClinicalTrials | ||
| Leukemia, Myeloid, Acute | 1 | D015470 | ClinicalTrials | ||
| Neoplasms | 1 | D009369 | ClinicalTrials | ||
| Lymphohistiocytosis, Hemophagocytic | 1 | D051359 | ClinicalTrials | ||
| Canavan Disease | 1 | D017825 | ClinicalTrials | ||
| Macular Degeneration | 1 | D008268 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 50-24-8 |
| ChEBI | 8378 |
| ChEMBL | CHEMBL131 |
| DrugBank | DB00860 |
| DrugCentral | 2245 |
| EPA CompTox | DTXSID9021184 |
| FDA SRS | 9PHQ9Y1OLM |
| Human Metabolome Database | HMDB0014998 |
| Guide to Pharmacology | 2866 |
| KEGG | C07369 |
| PDB | TUA |
| PharmGKB | PA451096 |
| PubChem | 5755 |
| SureChEMBL | SCHEMBL3233 |
| ZINC | ZINC000003833821 |
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