| Trade Names: | |
| Synonyms: | |
| Status: | Approved (1955) |
| Entry Type: | Small molecule |
| Molecule Category: | Salt Prodrug |
| UNII: | 8B2807733D |
| Parent Compound: | PREDNISOLONE |
Structure
| InChI Key | LRJOMUJRLNCICJ-JZYPGELDSA-N |
|---|---|
| Smile | |
| InChI |
|
Physicochemical Descriptors
| Property Name | Value |
|---|---|
| Molecular Formula | C23H30O6 |
| Molecular Weight | 402.49 |
| AlogP | 2.13 |
| Hydrogen Bond Acceptor | 6.0 |
| Hydrogen Bond Donor | 2.0 |
| Number of Rotational Bond | 3.0 |
| Polar Surface Area | 100.9 |
| Molecular species | NEUTRAL |
| Aromatic Rings | 0.0 |
| Heavy Atoms | 29.0 |
Pharmacology
| Action | Mechanism of Action | Reference |
|---|---|---|
| AGONIST | Glucocorticoid receptor agonist | FDA |
| Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | |
|---|---|---|---|---|---|---|
|
Transporter
Electrochemical transporter
SLC superfamily of solute carriers
SLC21/SLCO family of organic anion transporting polypeptides
|
- | - | - | - | 107 |
Indications
| Mesh Heading | Maximum Phase | Mesh ID | Reference |
|---|---|---|---|
| Conjunctivitis, Allergic | 4 | D003233 | ClinicalTrials |
| Uveitis | 3 | D014605 | ClinicalTrials |
| Sciatica | 3 | D012585 | ClinicalTrials |
| Uveitis, Anterior | 3 | D014606 | ClinicalTrials |
| Cataract | 3 | D002386 | ClinicalTrials |
| Eye Infections | 3 | D015817 | ClinicalTrials |
| Low Back Pain | 3 | D017116 | ClinicalTrials |
| Macular Edema | 2 | D008269 | ClinicalTrials |
| Retinal Vein Occlusion | 2 | D012170 | ClinicalTrials |
| Iritis | 2 | D007500 | ClinicalTrials |
Related Entries
Adverse Reactions
System Organ Classification (SOC)
Cross References
| Resources | Reference |
|---|---|
| CAS NUMBER | 52-21-1 |
| ChEBI | 8380 |
| ChEMBL | CHEMBL1152 |
| DrugBank | DB15566 |
| DrugCentral | 2247 |
| EPA CompTox | DTXSID3023502 |
| FDA SRS | 8B2807733D |
| KEGG | C08180 |
| PubChem | 5834 |
| SureChEMBL | SCHEMBL7999 |
| ZINC | ZINC000003875348 |
CONTENTS