TRIFLUPROMAZINE

Search structure
Trade Names:
Synonyms:
Status: Approved (1957)
Entry Type: Small molecule
Molecule Category: Parent
ATC: N05AA05
UNII: RO16TQF95Y

Structure
InChI Key XSCGXQMFQXDFCW-UHFFFAOYSA-N
Smile CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21
InChI
InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H19F3N2S
Molecular Weight 352.43
AlogP 5.26
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist KEGG Other PubMed PubMed PubMed Wikipedia
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Hydrolase
- 7400 - - 45
Enzyme Oxidoreductase
- - - 30200 12
Transporter Primary active transporter ATP-binding cassette ABCB subfamily
- 39010 - 15700 -
Transporter
- 39010 - 15700 -

Indications

Mesh Heading Maximum Phase Mesh ID Reference

Related Entries

MCS

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 146-54-3
ChEBI 9711
ChEMBL CHEMBL570
DrugBank DB00508
DrugCentral 2742
EPA CompTox DTXSID9023704
FDA SRS RO16TQF95Y
Human Metabolome Database HMDB0014650
Guide to Pharmacology 4330
PharmGKB PA451773
PubChem 5568
SureChEMBL SCHEMBL44085
ZINC ZINC000000538507
CONTENTS