TRIFLUPROMAZINE HYDROCHLORIDE

Search structure
Trade Names:
Synonyms:
Status: Approved (1957)
Entry Type: Small molecule
Molecule Category: Salt
UNII: 9E75N4A5HM
Parent Compound: TRIFLUPROMAZINE

Structure
InChI Key FTNWXGFYRHWUKG-UHFFFAOYSA-N
Smile CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl
InChI
InChI=1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H20ClF3N2S
Molecular Weight 388.89
AlogP 5.26
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 0.0
Number of Rotational Bond 4.0
Polar Surface Area 6.48
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 24.0

Pharmacology

Action Mechanism of Action Reference
ANTAGONIST Dopamine D2 receptor antagonist
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- - - -
Epigenetic regulator Eraser Histone deacetylase HDAC class IIb
- 3697 - - 13.82-89.18
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 185.58

Related Entries

Scaffolds

Parent

Cross References

Resources Reference
ChEBI 9712
ChEMBL CHEMBL1201102
EPA CompTox DTXSID8045804
FDA SRS 9E75N4A5HM
Guide to Pharmacology 4330
KEGG D00390
PubChem 66069
SureChEMBL SCHEMBL317144
ZINC ZINC00538507
CONTENTS