MECAMYLAMINE

Search structure
Synonyms:
Status: Approved (1956)
Entry Type: Small molecule
Molecule Category: Parent
ATC: C02BB01
UNII: 6EE945D3OK

Structure
InChI Key IMYZQPCYWPFTAG-UHFFFAOYSA-N
Smile CNC1(C)C2CCC(C2)C1(C)C
InChI
InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3

Physicochemical Descriptors

Property Name Value
Molecular Formula C11H21N
Molecular Weight 167.3
AlogP 2.42
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 1.0
Polar Surface Area 12.03
Molecular species BASE
Aromatic Rings 0.0
Heavy Atoms 12.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor alpha subunit
200 100-3800 - - 0
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor beta subunit
200 100-3800 - - 88
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor delta subunit
30000 - - - -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor epsilon subunit
30000 - - - -
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor Nicotinic acetylcholine receptor gamma subunit
30000 - - - -

Indications

Mesh Heading Maximum Phase Mesh ID Reference
Macular Degeneration 2 D008268 ClinicalTrials
Depressive Disorder, Major 2 D003865 ClinicalTrials
Tobacco Use Disorder 2 D014029 ClinicalTrials
Alcoholism 2 D000437 ClinicalTrials
Macular Degeneration 2 D008268 ClinicalTrials
Aging 1 D000375 ClinicalTrials
Autistic Disorder 1 D001321 ClinicalTrials
Cognitive Dysfunction 0 D060825 ClinicalTrials

Related Entries

Scaffolds

Salt

Cross References

Resources Reference
CAS NUMBER 60-40-2
ChEBI 6706
ChEMBL CHEMBL267936
DrugBank DB00657
DrugCentral 1646
EPA CompTox DTXSID0023240
FDA SRS 6EE945D3OK
Human Metabolome Database HMDB0014795
Guide to Pharmacology 3990
KEGG C07511
PharmGKB PA450334
SureChEMBL SCHEMBL34252
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