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Total: 6532
Small molecule
Unknown
Unknown
Unknown
Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Central Nervous System Neoplasms; Inflammatory Breast Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Lymphoma; Sarcoma; Breast Neoplasms; Cardiomyopathies
Unknown
Small molecule
Unknown
Unknown
Unknown
Osteomyelitis; Pyelonephritis; Bacterial Infections; Bronchitis, Chronic; Otitis Media
Bacterial penicillin-binding protein inhibitor
Small molecule
Approved
OTHER
ORAL
Fallopian Tube Neoplasms; Gynecomastia; Ovarian Neoplasms; Peritoneal Neoplasms; Puberty, Precocious; Salivary Gland Neoplasms; Breast Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Severe Acute Respiratory Syndrome; Carcinoma; Neoplasms
Androgen Receptor antagonist
Small molecule
Approved
IMMUNE SYSTEM
ORAL
Hypertension, Pulmonary; Acquired Immunodeficiency Syndrome; AIDS-Associated Nephropathy; HIV Infections; Virus Diseases
Human immunodeficiency virus type 1 protease inhibitor
Small molecule
Approved
Unknown
Unknown
Ependymoma; Glioma; Infectious Mononucleosis; Lung Neoplasms; Prostatic Neoplasms; Astrocytoma; Bipolar Disorder; Cytomegalovirus Infections; Glioblastoma; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Neuralgia, Postherpetic; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Schizophrenia; Stomatitis, Herpetic; Waldenstrom Macroglobulinemia; Encephalitis; Herpes Simplex; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases
Unknown
Small molecule
Approved
OTHER; RESPIRATORY
ORAL
Breast Neoplasms; Ovarian Neoplasms; Asthma; Lung Diseases, Obstructive
Cysteinyl leukotriene receptor 1 antagonist
Small molecule
Approved
CANCER; OTHER; PREGNANCY AND GYNECOLOGY
INJECTION; INTRAVENOUS
Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Adenocarcinoma; Anus Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Neuroendocrine; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Head and Neck Neoplasms; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
Tubulin inhibitor
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Postoperative Nausea and Vomiting; Sleep Apnea, Obstructive; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Fibromyalgia; Glioma; Substance-Related Disorders; Weight Loss; Anorexia; Anxiety; Cachexia; Child Development Disorders, Pervasive; Dementia; Heroin Dependence; Nausea; Schizophrenia; Depressive Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders
Adrenergic receptor alpha-2 antagonist
Small molecule
Approved
Unknown
Unknown
Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
Unknown
Small molecule
Approved
Unknown
ORAL
Hepatitis C, Chronic; Infertility, Male; Hepatitis C; Hyperoxaluria, Primary; Non-alcoholic Fatty Liver Disease; Obesity; Depressive Disorder; Homocystinuria
Betaine-homocysteine S-methyltransferase substrate
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Kidney Diseases; Communicable Diseases; Enterobacteriaceae Infections; Pyelonephritis; Shock, Septic; Urinary Tract Infections; Bacterial Infections
Unknown
Small molecule
Approved
CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Cardiomyopathy, Hypertrophic; Nephritis, Hereditary; Peripheral Arterial Disease; Renal Insufficiency, Chronic; Atherosclerosis; Atrial Fibrillation; Chagas Cardiomyopathy; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Pulmonary; Kidney Diseases; Lipid Metabolism Disorders; Metabolic Syndrome; Non-ST Elevated Myocardial Infarction; ST Elevation Myocardial Infarction; Cardiovascular Diseases; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke; Ventricular Dysfunction, Left
Type-1 angiotensin II receptor antagonist
Small molecule
Approved
Unknown
Unknown
Hepatopulmonary Syndrome; Hypotension, Orthostatic; Ischemic Stroke; Ascites; Hypotension; Shock, Septic; Spinal Cord Injuries; Cardiovascular Diseases
Unknown
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left
Angiotensin-converting enzyme inhibitor
Small molecule
Approved
Unknown
Unknown
Desmoplastic Small Round Cell Tumor; Astrocytoma; Bone Neoplasms; Carcinoid Tumor; Diffuse Intrinsic Pontine Glioma; Digestive System Neoplasms; Endometrial Neoplasms; Kidney Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Mesothelioma; Oligodendroglioma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangiosarcoma; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Pinealoma; Pulmonary Disease, Chronic Obstructive; Rhabdomyosarcoma; Sarcoma; Wilms Tumor; Adenocarcinoma, Mucinous; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Cholangiocarcinoma; Choroid Plexus Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Hepatoblastoma; Lung Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Sleep Apnea Syndromes; Premature Birth; Sleep Apnea, Obstructive; Brain Neoplasms; Obesity, Morbid; Respiratory Insufficiency; Ear Neoplasms; Heart Diseases; Neoplasms; Neuralgia, Postherpetic; Opioid-Related Disorders; Pain; Stroke
Unknown
Small molecule
Approved
Unknown
Unknown
Melanoma; Muscle Spasticity; Pain
Unknown
Small molecule
Approved
Unknown
Unknown
Stress Disorders, Post-Traumatic; Fasciitis, Plantar; Hernia, Inguinal; Rib Fractures; Appendicitis; Hallux Valgus; Joint Diseases; Leiomyoma; Osteoarthritis; Rotator Cuff Injuries; Shoulder Pain; Abdominal Pain; Breast Neoplasms; Chronic Pain; Hypotension; Knee Injuries; Neoplasms; Ovarian Cysts; Ovarian Neoplasms; Pain; Paralysis; Stomach Neoplasms
Unknown
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
ORAL
Feeding and Eating Disorders; Bulimia Nervosa; Cognitive Dysfunction; Hernias, Diaphragmatic, Congenital; Liver Diseases; Alcohol Drinking; Amphetamine-Related Disorders; Brain Ischemia; Diabetes Mellitus; Marijuana Abuse; Multiple Sclerosis; Parkinson Disease; Sciatica; Stress Disorders, Post-Traumatic; Alcoholism; Anxiety; Bipolar Disorder; Bulimia; Cocaine-Related Disorders; Dementia; Depressive Disorder; Diabetes Mellitus, Type 2; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Essential Tremor; Gambling; Headache; Hyperlipidemias; Hypertension; Hypertriglyceridemia; Metabolic Syndrome; Obesity; Obsessive-Compulsive Disorder; Pain; Prader-Willi Syndrome; Schizophrenia; Smoking Cessation; Tobacco Use Disorder; Tourette Syndrome; Epilepsy; Lennox Gastaut Syndrome; Migraine Disorders; Seizures
Carbonic anhydrase II inhibitor
Small molecule
Approved
Unknown
Unknown
Amblyopia; Central Nervous System Diseases; Skin Diseases; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Delirium; Diabetes Mellitus, Type 2; Fragile X Syndrome; Neuralgia; Supranuclear Palsy, Progressive; Tobacco Use Disorder; Wounds and Injuries; Alzheimer Disease; Anxiety; Aphasia; Cognitive Dysfunction; Dementia, Vascular; Depressive Disorder; Ischemic Stroke; Multiple Sclerosis; Neoplasms; Parkinson Disease; Schizophrenia; Stroke; Dementia
Unknown
Small molecule
Approved
IMMUNE SYSTEM; OTHER
DENTAL; TOPICAL
Stomatitis; Lung Diseases, Obstructive
Phosphodiesterase 4 inhibitor
Small molecule
Unknown
Unknown
Unknown
Infections; Osteomyelitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pseudomonas Infections; Appendicitis; Neonatal Sepsis; Neoplasms; Pneumonia, Bacterial; Pyelonephritis; Gonorrhea; Staphylococcal Infections; Urinary Tract Infections; Bacterial Infections
Unknown
Small molecule
Approved
Unknown
Unknown
Myositis, Inclusion Body; Neuroblastoma; beta-Thalassemia; Brain Neoplasms; HIV Infections; Maple Syrup Urine Disease; Tuberculosis, Pulmonary
Unknown
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
ORAL
Breast Neoplasms; Obesity; Substance-Related Disorders; Cocaine-Related Disorders; Endometriosis; Infertility; Paget Disease, Extramammary; Pituitary ACTH Hypersecretion; Acromegaly; Diabetes Mellitus; Ovarian Hyperstimulation Syndrome; Restless Legs Syndrome; Parkinson Disease; Pituitary Neoplasms
Dopamine D2 receptor agonist
Small molecule
Unknown
Unknown
Unknown
Unknown
Mu opioid receptor agonist
Small molecule
Approved
Unknown
Unknown
Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Eye Manifestations; Hypersensitivity; Nasal Obstruction
Unknown
Small molecule
Approved
Unknown
Unknown
Attention Deficit Disorder with Hyperactivity; Narcolepsy
Dopamine transporter releasing agent
Small molecule
Approved
OTHER
INJECTION
Diffuse Intrinsic Pontine Glioma; Bile Duct Neoplasms; Brain Neoplasms; Leukemia; Lymphoma, T-Cell, Cutaneous; Sarcoma, Synovial; Stomach Neoplasms; Adenocarcinoma; Adenocarcinoma of Lung; Anxiety; Biliary Tract Diseases; Carcinoma, Large Cell; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Digestive System Diseases; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Head and Neck Neoplasms; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia-Lymphoma, Adult T-Cell; Liver Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Small Cell Lung Carcinoma; Testicular Neoplasms; Thyroid Neoplasms; Urethral Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Immunoblastic Lymphadenopathy; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Sarcoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
IMMUNE SYSTEM
ORAL
Hookworm Infections; Trichuriasis; Cysticercosis; Ectoparasitic Infestations; Elephantiasis, Filarial; Filariasis; HIV Infections; Malaria; Malnutrition; Onchocerciasis; Strongyloidiasis; Toxocariasis; Helminthiasis; Infections; Neurocysticercosis
Tubulin inhibitor
Small molecule
Approved
IMMUNE SYSTEM; OTHER; PEDIATRICS
ORAL
Amyotrophic Lateral Sclerosis; Erectile Dysfunction; Glioblastoma; Hypertension; Hypertension, Pulmonary; Insulin Resistance; Kidney Diseases; Liver Diseases; Malaria; Neoplasm Metastasis; Respiratory Distress Syndrome; Tuberculosis; Coronavirus Infections; Hepatitis B, Chronic; Mycobacterium avium-intracellulare Infection; Neoplasms; Pregnancy; Sarcoma; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Hepatitis D; Infections; Severe Acute Respiratory Syndrome; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Virus Diseases
Cytochrome P450 3A inhibitor
Small molecule
Unknown
Unknown
Unknown
Amyotrophic Lateral Sclerosis; Cystic Fibrosis; Lymphoma; Muscular Atrophy, Spinal; Myelodysplastic-Myeloproliferative Diseases; Myelodysplastic Syndromes; Pyruvate Dehydrogenase Complex Deficiency Disease; Argininosuccinic Aciduria; HIV Infections; Huntington Disease; Leukemia; Machado-Joseph Disease; Tuberculosis, Pulmonary; Hyperammonemia; Urea Cycle Disorders, Inborn
Glutamine sequestering agent
Small molecule
Approved
Unknown
Unknown
Hemorrhagic Fever, Ebola; Metabolic Syndrome; Breast Neoplasms; Hepatitis C; Paraplegia; Periodontitis; Atherosclerosis; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hyperlipoproteinemia Type IV; Hypertriglyceridemia; Lipid Metabolism Disorders; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia
Unknown
Small molecule
Approved
Unknown
Unknown
Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Neuroblastoma; Uterine Cervical Neoplasms; Uterine Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms
Unknown
Small molecule
Approved
EYE; IMMUNE SYSTEM; OTHER
INJECTION
Herpes Simplex; Kidney Diseases; Uterine Cervical Neoplasms; Anus Neoplasms; Infections; Papilloma; Sarcoma; Uterine Cervical Dysplasia; Cytomegalovirus Infections; Cytomegalovirus Retinitis; Primary Immunodeficiency Diseases; Virus Diseases
Human herpesvirus 1 DNA polymerase inhibitor