DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 6532


Small molecule Approved OTHER INHALATION Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis Prostanoid IP receptor agonist

Small molecule

Approved

OTHER

INHALATION

Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis

Prostanoid IP receptor agonist


Small molecule Approved Unknown Unknown Constipation Unknown


Small molecule Approved Unknown Unknown Amphetamine-Related Disorders; Emergence Delirium; Stress Disorders, Post-Traumatic; Stroke; Alcoholism; Attention Deficit Disorder with Hyperactivity; Colorectal Neoplasms; Diabetes Mellitus; Diabetic Nephropathies; Fatigue Syndrome, Chronic; Lung Diseases, Interstitial; Multiple Sclerosis; Myalgia; Neuralgia; Pain; Anxiety; Anxiety Disorders; Back Pain; Biliary Dyskinesia; Burning Mouth Syndrome; Cognitive Dysfunction; Dementia; Depressive Disorder; Depressive Disorder, Major; Diabetic Neuropathies; Fibromyalgia; Low Back Pain; Osteoarthritis; Osteoarthritis, Knee; Parkinson Disease; Peripheral Nervous System Diseases; Schizophrenia; Shoulder Pain; Urinary Incontinence; Urinary Incontinence, Stress Unknown

Small molecule

Approved

Unknown

Amphetamine-Related Disorders; Emergence Delirium; Stress Disorders, Post-Traumatic; Stroke; Alcoholism; Attention Deficit Disorder with Hyperactivity; Colorectal Neoplasms; Diabetes Mellitus; Diabetic Nephropathies; Fatigue Syndrome, Chronic; Lung Diseases, Interstitial; Multiple Sclerosis; Myalgia; Neuralgia; Pain; Anxiety; Anxiety Disorders; Back Pain; Biliary Dyskinesia; Burning Mouth Syndrome; Cognitive Dysfunction; Dementia; Depressive Disorder; Depressive Disorder, Major; Diabetic Neuropathies; Fibromyalgia; Low Back Pain; Osteoarthritis; Osteoarthritis, Knee; Parkinson Disease; Peripheral Nervous System Diseases; Schizophrenia; Shoulder Pain; Urinary Incontinence; Urinary Incontinence, Stress

Unknown


Small molecule Approved Unknown Unknown Prostatic Hyperplasia; Urinary Bladder, Overactive; Urinary Incontinence, Urge Muscarinic acetylcholine receptor M2 antagonist


Small molecule Approved OTHER; RESPIRATORY INHALATION Cystic Fibrosis; Neoplasms; Spinal Cord Injuries; Asthma; Bronchial Spasm; Bronchitis, Chronic; Emphysema; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive Muscarinic acetylcholine receptor M3 antagonist


Small molecule Approved IMMUNE SYSTEM; OTHER; RESPIRATORY ORAL Asthma; Maxillary Sinusitis; Otitis Media; Otitis Media, Suppurative; Scrub Typhus; Bacterial Infections; Bronchitis, Chronic; Community-Acquired Infections; Infections; Pharyngitis; Pneumonia; Pneumonia, Bacterial; Sinusitis; Tonsillitis Bacterial 70S ribosome inhibitor


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms Dihydrofolate reductase inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms

Dihydrofolate reductase inhibitor


Small molecule Approved OTHER INTRAVENOUS Breast Neoplasms; Hernias, Diaphragmatic, Congenital Diagnostic agent


Small molecule Approved Unknown Unknown Urinary Incontinence, Urge; Prostatic Hyperplasia; Urinary Bladder, Overactive; Polyuria; Urinary Incontinence Unknown


Small molecule Approved Unknown Unknown Brain Neoplasms; Lymphoma Unknown


Small molecule Approved Unknown Unknown Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Crohn Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyspepsia; Eczema; Head and Neck Neoplasms; Propionic Acidemia; Renal Insufficiency, Chronic; Anxiety Disorders; Breast Neoplasms; Clostridium Infections; Cross Infection; Cystic Fibrosis; Heart Failure; Herpes Labialis; Herpes Simplex; Irritable Bowel Syndrome; Lymphoma; Multiple Myeloma; Periodontitis; Prostatic Neoplasms, Castration-Resistant; Thalassemia; Wounds and Injuries; Colorectal Neoplasms; Coronary Disease; Diarrhea; Fetal Growth Retardation; Malnutrition; Mucositis; Multiple Organ Failure; Muscular Dystrophy, Duchenne; Neoplasms; Peripheral Nervous System Diseases; Premature Birth; Sepsis; Severe Acute Respiratory Syndrome; Stomatitis; Anemia, Sickle Cell; Short Bowel Syndrome Unknown

Small molecule

Approved

Unknown

Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Crohn Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyspepsia; Eczema; Head and Neck Neoplasms; Propionic Acidemia; Renal Insufficiency, Chronic; Anxiety Disorders; Breast Neoplasms; Clostridium Infections; Cross Infection; Cystic Fibrosis; Heart Failure; Herpes Labialis; Herpes Simplex; Irritable Bowel Syndrome; Lymphoma; Multiple Myeloma; Periodontitis; Prostatic Neoplasms, Castration-Resistant; Thalassemia; Wounds and Injuries; Colorectal Neoplasms; Coronary Disease; Diarrhea; Fetal Growth Retardation; Malnutrition; Mucositis; Multiple Organ Failure; Muscular Dystrophy, Duchenne; Neoplasms; Peripheral Nervous System Diseases; Premature Birth; Sepsis; Severe Acute Respiratory Syndrome; Stomatitis; Anemia, Sickle Cell; Short Bowel Syndrome

Unknown


Small molecule Approved Unknown Unknown Atrophy; Menopause Estrogen receptor agonist


Small molecule Approved Unknown Unknown Amyotrophic Lateral Sclerosis; Urinary Bladder, Overactive; Polyuria; Urinary Incontinence Unknown


Small molecule Approved Unknown Unknown Rickets, Hypophosphatemic; Chronic Kidney Disease-Mineral and Bone Disorder; Hyperparathyroidism, Primary; Memory Disorders; Hyperparathyroidism; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Renal Insufficiency, Chronic; Parathyroid Diseases Unknown


Small molecule Approved CANCER INJECTION; INTRAVENOUS Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Graft vs Host Disease; Hematologic Diseases; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Osteopetrosis; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma DNA inhibitor

Small molecule

Approved

CANCER

INJECTION; INTRAVENOUS

Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Graft vs Host Disease; Hematologic Diseases; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Osteopetrosis; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

DNA inhibitor


Small molecule Approved OTHER OPHTHALMIC Unknown Diagnostic


Small molecule Approved Unknown Unknown Carcinoma, Squamous Cell; Cheilitis; Uterine Cervical Dysplasia; Acne Vulgaris; Carcinoma, Basal Cell; Keratosis, Actinic; Skin Aging; Neoplasms Unknown


Small molecule Approved EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Carcinoma, Squamous Cell; Cough; Essential Tremor; Marijuana Abuse; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Tobacco Use Disorder; Alcoholism; Complex Regional Pain Syndromes; Dental Anxiety; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Breast Neoplasms; Burning Mouth Syndrome; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Headache; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Anxiety Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries Voltage-gated calcium channel modulator

Small molecule

Approved

EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Carcinoma, Squamous Cell; Cough; Essential Tremor; Marijuana Abuse; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Tobacco Use Disorder; Alcoholism; Complex Regional Pain Syndromes; Dental Anxiety; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Breast Neoplasms; Burning Mouth Syndrome; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Headache; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Anxiety Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries

Voltage-gated calcium channel modulator


Small molecule Approved Unknown Unknown Amphetamine-Related Disorders; Autistic Disorder; Tinnitus; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Essential Tremor; Feeding and Eating Disorders; Fragile X Syndrome; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Alcoholism Unknown


Small molecule Approved OTHER ORAL Breast Carcinoma In Situ; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chagas Cardiomyopathy; Colorectal Neoplasms; Fatty Liver; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Severe Acute Respiratory Syndrome; Urinary Bladder Neoplasms; Wounds and Injuries; Aggression; Autistic Disorder; Bipolar Disorder; Breast Neoplasms; Child Development Disorders, Pervasive; Cognitive Dysfunction; Depression, Postpartum; Depressive Disorder; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Dysthymic Disorder; Epilepsy; Glomerulonephritis, IGA; Inflammation; Lichen Planus, Oral; Myositis; Oral Ulcer; Periodontitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychotic Disorders; Renal Insufficiency, Chronic; Sarcopenia; Schizophrenia; Stomatitis; Acne Vulgaris; Alzheimer Disease; Atrial Fibrillation; Attention Deficit Disorder with Hyperactivity; Dry Eye Syndromes; Endocrine System Diseases; Heart Diseases; Heart Failure; HIV Infections; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Hypertension; Hypertriglyceridemia; Insulin Resistance; Intermittent Claudication; Language Disorders; Lipid Metabolism Disorders; Metabolic Diseases; Myocardial Infarction; Myocardial Ischemia; Non-alcoholic Fatty Liver Disease; Peripheral Arterial Disease; Pyelonephritis; Vascular Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypothyroidism Unknown

Small molecule

Approved

OTHER

ORAL

Breast Carcinoma In Situ; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chagas Cardiomyopathy; Colorectal Neoplasms; Fatty Liver; Lymphoma, Non-Hodgkin; Melanoma; Metabolic Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Severe Acute Respiratory Syndrome; Urinary Bladder Neoplasms; Wounds and Injuries; Aggression; Autistic Disorder; Bipolar Disorder; Breast Neoplasms; Child Development Disorders, Pervasive; Cognitive Dysfunction; Depression, Postpartum; Depressive Disorder; Depressive Disorder, Major; Diabetes Mellitus, Type 1; Dysthymic Disorder; Epilepsy; Glomerulonephritis, IGA; Inflammation; Lichen Planus, Oral; Myositis; Oral Ulcer; Periodontitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychotic Disorders; Renal Insufficiency, Chronic; Sarcopenia; Schizophrenia; Stomatitis; Acne Vulgaris; Alzheimer Disease; Atrial Fibrillation; Attention Deficit Disorder with Hyperactivity; Dry Eye Syndromes; Endocrine System Diseases; Heart Diseases; Heart Failure; HIV Infections; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Hypertension; Hypertriglyceridemia; Insulin Resistance; Intermittent Claudication; Language Disorders; Lipid Metabolism Disorders; Metabolic Diseases; Myocardial Infarction; Myocardial Ischemia; Non-alcoholic Fatty Liver Disease; Peripheral Arterial Disease; Pyelonephritis; Vascular Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypothyroidism

Unknown


Small molecule Approved Unknown Unknown Alcoholism; Brain Injuries; Hallucinations; Erectile Dysfunction; Parkinson Disease Unknown


Small molecule Approved Unknown Unknown Urinary Bladder, Overactive; Polyuria; Urinary Incontinence Unknown


Small molecule Approved Unknown Unknown Kidney Diseases; Hyperphosphatemia; Kidney Failure, Chronic Phosphate sequestering agent


Small molecule Approved OTHER ORAL Myelodysplastic Syndromes; Primary Myelofibrosis; Scleroderma, Systemic; Crohn Disease; Dry Eye Syndromes; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Renal Insufficiency, Chronic; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Graft vs Host Disease; Lupus Erythematosus, Systemic; Lupus Nephritis; Nephrotic Syndrome; Sarcoidosis, Pulmonary; Uveitis, Intermediate; Immune System Diseases Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Small molecule

Approved

OTHER

ORAL

Myelodysplastic Syndromes; Primary Myelofibrosis; Scleroderma, Systemic; Crohn Disease; Dry Eye Syndromes; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Renal Insufficiency, Chronic; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Graft vs Host Disease; Lupus Erythematosus, Systemic; Lupus Nephritis; Nephrotic Syndrome; Sarcoidosis, Pulmonary; Uveitis, Intermediate; Immune System Diseases

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Renal Insufficiency, Chronic; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections Bacterial DNA-directed RNA polymerase inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

ORAL

Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Renal Insufficiency, Chronic; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections

Bacterial DNA-directed RNA polymerase inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Malaria, Vivax; Urethritis; Candidiasis; Helicobacter Infections; Stomach Neoplasms; Vaginitis; Amebiasis; Bacterial Infections; Trichomonas Infections; Vaginosis, Bacterial DNA disrupting agent

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS; SUBCUTANEOUS

Acute Kidney Injury; Blastic Plasmacytoid Dendritic Cell Neoplasm; Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Mastocytosis, Systemic; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Sarcoma; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Lymphoma, Follicular; Melanoma; Multiple Myeloma; Myeloproliferative Disorders; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Thrombocytopenia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Marijuana Abuse; Burns; Migraine with Aura; Migraine without Aura; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Depressive Disorder; Sleep Wake Disorders; Sleep Initiation and Maintenance Disorders

Melatonin receptor agonist

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Lymphoma, Primary Effusion; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Autistic Disorder; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Neoplasms, Plasma Cell; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Neuralgia; Epilepsy; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Low Back Pain; Pain; Schizophrenia; Anxiety; Lennox Gastaut Syndrome; Seizures GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved OTHER ORAL Liver Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Anemia; Hemochromatosis; Leukemia, Myeloid, Acute; Mucormycosis; Osteoporosis, Postmenopausal; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Hemosiderosis; Porphyria Cutanea Tarda; Thalassemia; beta-Thalassemia; Iron Overload; Myelodysplastic Syndromes Iron chelating agent

Small molecule

Approved

CANCER

INTRAVENOUS

Leukemia, Lymphoid; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasms, Plasma Cell; Leukemia, Biphenotypic, Acute; Lymphoma; Mycosis Fungoides; Sezary Syndrome; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia-Lymphoma, Adult T-Cell; Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

DNA inhibitor

Small molecule

Approved

DERMATOLOGY

INTRAVENOUS

Leukemia, Myeloid, Acute; Liver Cirrhosis, Biliary; Renal Insufficiency, Chronic; Bacteremia; Lung Diseases; Abdominal Abscess; Diabetic Foot; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Osteomyelitis; Pneumonia, Bacterial; Skin Diseases; Staphylococcal Infections; Bacterial Infections; Infections; Intraabdominal Infections; Skin Diseases, Bacterial; Skin Diseases, Infectious; Soft Tissue Infections

Bacterial 70S ribosome inhibitor


Small molecule Approved Unknown Unknown Osteoarthritis, Knee; Carpal Tunnel Syndrome; Myofascial Pain Syndromes; Neuralgia, Postherpetic; Shoulder Impingement Syndrome; Skin Diseases; Tendinopathy; Wounds and Injuries; Cataract; Hemorrhoids; Pain; Pruritus Sodium channel alpha subunit blocker


Small molecule Approved OTHER; PEDIATRICS ORAL Hemorrhage; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 protease inhibitor