DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 1496


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Urinary Tract Infections; Bronchitis, Chronic; Infections; Pharyngitis; Tonsillitis Bacterial penicillin-binding protein inhibitor


Small molecule Approved OTHER ORAL Cystic Fibrosis; Diabetes Mellitus, Type 2; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Infertility, Female; Leukemia, Lymphocytic, Chronic, B-Cell; Non-alcoholic Fatty Liver Disease; Obesity; Bulimia; Bulimia Nervosa; Depressive Disorder; Endometrial Neoplasms; Hidradenitis Suppurativa; Hyperandrogenism; Metrorrhagia; Osteoporosis; Premenstrual Syndrome; Amenorrhea; Anorexia Nervosa; Bone Diseases, Metabolic; Breast Neoplasms; Dysmenorrhea; Endometriosis; Migraine Disorders; Neural Tube Defects; Polycystic Ovary Syndrome; Pregnancy; Turner Syndrome; Acne Vulgaris; Neoplasms Estrogen receptor alpha agonist

Small molecule

Approved

OTHER

ORAL

Cystic Fibrosis; Diabetes Mellitus, Type 2; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Infertility, Female; Leukemia, Lymphocytic, Chronic, B-Cell; Non-alcoholic Fatty Liver Disease; Obesity; Bulimia; Bulimia Nervosa; Depressive Disorder; Endometrial Neoplasms; Hidradenitis Suppurativa; Hyperandrogenism; Metrorrhagia; Osteoporosis; Premenstrual Syndrome; Amenorrhea; Anorexia Nervosa; Bone Diseases, Metabolic; Breast Neoplasms; Dysmenorrhea; Endometriosis; Migraine Disorders; Neural Tube Defects; Polycystic Ovary Syndrome; Pregnancy; Turner Syndrome; Acne Vulgaris; Neoplasms

Estrogen receptor alpha agonist


Small molecule Approved OTHER; UROLOGY AND KIDNEY ORAL Aging; Amyotrophic Lateral Sclerosis; Bulbo-Spinal Atrophy, X-Linked; Prostatitis; Severe Acute Respiratory Syndrome; Alopecia; Hypogonadism; Prostatic Neoplasms, Castration-Resistant; Prostatic Hyperplasia; Prostatic Neoplasms Steroid 5-alpha-reductase inhibitor


Protein Approved OTHER; RHEUMATOLOGY SUBCUTANEOUS Asthma; Blepharitis; Breast Neoplasms; Endometriosis; Granulomatous Disease, Chronic; Hearing Loss; HIV Infections; Hypertension, Pulmonary; Knee Injuries; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis; Neoplasms; Pain; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Smoldering Multiple Myeloma; Amyotrophic Lateral Sclerosis; Arthritis, Juvenile; Brain Injuries; Cerebral Hemorrhage; Cystic Fibrosis; Dermatomyositis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fatigue Syndrome, Chronic; Gout; Heart Failure; Hepatitis, Alcoholic; Hidradenitis Suppurativa; Hypoglycemia; Infections; Lymphoma, Follicular; Macrophage Activation Syndrome; Meniere Disease; Mucopolysaccharidosis II; Multiple Myeloma; Myositis, Inclusion Body; Osteoarthritis; Polycystic Ovary Syndrome; Renal Insufficiency, Chronic; Respiratory Distress Syndrome; Severe Dengue; Uveitis; Virus Diseases; Dermatitis, Allergic Contact; Familial Mediterranean Fever; Giant Cell Arteritis; Influenza, Human; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Myocardial Infarction; Pericarditis; Pneumonia; Sepsis; Severe Acute Respiratory Syndrome; Still's Disease, Adult-Onset; Arthritis, Rheumatoid; COVID-19; Cryopyrin-Associated Periodic Syndromes; Immune System Diseases Interleukin-1 receptor antagonist

Protein

Approved

OTHER; RHEUMATOLOGY

SUBCUTANEOUS

Asthma; Blepharitis; Breast Neoplasms; Endometriosis; Granulomatous Disease, Chronic; Hearing Loss; HIV Infections; Hypertension, Pulmonary; Knee Injuries; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Sclerosis; Neoplasms; Pain; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Smoldering Multiple Myeloma; Amyotrophic Lateral Sclerosis; Arthritis, Juvenile; Brain Injuries; Cerebral Hemorrhage; Cystic Fibrosis; Dermatomyositis; Diabetes Mellitus; Diabetes Mellitus, Type 1; Fatigue Syndrome, Chronic; Gout; Heart Failure; Hepatitis, Alcoholic; Hidradenitis Suppurativa; Hypoglycemia; Infections; Lymphoma, Follicular; Macrophage Activation Syndrome; Meniere Disease; Mucopolysaccharidosis II; Multiple Myeloma; Myositis, Inclusion Body; Osteoarthritis; Polycystic Ovary Syndrome; Renal Insufficiency, Chronic; Respiratory Distress Syndrome; Severe Dengue; Uveitis; Virus Diseases; Dermatitis, Allergic Contact; Familial Mediterranean Fever; Giant Cell Arteritis; Influenza, Human; Metabolic Syndrome; Mucocutaneous Lymph Node Syndrome; Myocardial Infarction; Pericarditis; Pneumonia; Sepsis; Severe Acute Respiratory Syndrome; Still's Disease, Adult-Onset; Arthritis, Rheumatoid; COVID-19; Cryopyrin-Associated Periodic Syndromes; Immune System Diseases

Interleukin-1 receptor antagonist


Small molecule Approved GASTROINTESTINAL; OTHER ORAL Constipation; Irritable Bowel Syndrome Serotonin 4 (5-HT4) receptor partial agonist


Protein Approved GASTROINTESTINAL; OTHER INTRAVENOUS Autistic Disorder Secretin receptor agonist


Protein Approved GASTROINTESTINAL; OTHER INJECTION Dyspepsia; Pancreatitis, Chronic; Obesity; Pancreatitis; Schizophrenia; Autistic Disorder Secretin receptor agonist


Small molecule Approved CARDIOVASCULAR; OTHER; RESPIRATORY INHALATION; INTRAVENOUS; IV (INFUSION); SUBCUTANEOUS Diabetes Mellitus, Type 1; Diabetic Foot; Raynaud Disease; Reperfusion Injury; Scleroderma, Systemic; Hernias, Diaphragmatic, Congenital; Ischemia; Peripheral Vascular Diseases; Persistent Fetal Circulation Syndrome; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Familial Primary Pulmonary Hypertension; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis Prostanoid IP receptor agonist

Small molecule

Approved

CARDIOVASCULAR; OTHER; RESPIRATORY

INHALATION; INTRAVENOUS; IV (INFUSION); SUBCUTANEOUS

Diabetes Mellitus, Type 1; Diabetic Foot; Raynaud Disease; Reperfusion Injury; Scleroderma, Systemic; Hernias, Diaphragmatic, Congenital; Ischemia; Peripheral Vascular Diseases; Persistent Fetal Circulation Syndrome; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome; Familial Primary Pulmonary Hypertension; Idiopathic Pulmonary Fibrosis; Lung Diseases, Interstitial; Pulmonary Fibrosis; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis

Prostanoid IP receptor agonist


Protein Approved IMMUNE SYSTEM; OTHER SUBCUTANEOUS; UNKNOWN Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Breast Neoplasms; Carcinoma, Hepatocellular; Clostridium Infections; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Hepatitis, Chronic; Kidney Diseases; Multiple Myeloma; Thrombocytopenia; Depressive Disorder; Hepatitis; Hepatitis C; Hepatitis D; HIV Infections; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Cirrhosis; Melanoma; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Hepatitis B; Hepatitis B, Chronic; Hepatitis C, Chronic; Neoplasms Interferon alpha/beta receptor agonist

Protein

Approved

IMMUNE SYSTEM; OTHER

SUBCUTANEOUS; UNKNOWN

Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Breast Neoplasms; Carcinoma, Hepatocellular; Clostridium Infections; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Hepatitis, Chronic; Kidney Diseases; Multiple Myeloma; Thrombocytopenia; Depressive Disorder; Hepatitis; Hepatitis C; Hepatitis D; HIV Infections; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver Cirrhosis; Melanoma; Polycythemia Vera; Primary Myelofibrosis; Thrombocythemia, Essential; Hepatitis B; Hepatitis B, Chronic; Hepatitis C, Chronic; Neoplasms

Interferon alpha/beta receptor agonist


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS Digestive System Diseases; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Triple Negative Breast Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Klatskin Tumor; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms DNA inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS

Digestive System Diseases; Gastrointestinal Stromal Tumors; Glioblastoma; Gliosarcoma; Hematologic Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Diseases; Lymphoma, T-Cell, Cutaneous; Melanoma; Myelodysplastic Syndromes; Neuroblastoma; Triple Negative Breast Neoplasms; Anus Neoplasms; Bile Duct Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, Islet Cell; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Klatskin Tumor; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroendocrine Tumors; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Esophageal Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms; Teratoma; Testicular Neoplasms; Neoplasms

DNA inhibitor


Small molecule Approved OTHER; PEDIATRICS ORAL Albinism; Alkaptonuria; Tyrosinemias 4-hydroxyphenylpyruvate dioxygenase inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER; PEDIATRICS ORAL HIV Infections; Irritable Bowel Syndrome; Kidney Diseases; Liver Diseases; Bronchiolitis; Crohn Disease; Diabetes Mellitus, Type 2; Gastroenteritis; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Malnutrition; Periodontitis; Sexually Transmitted Diseases; Tuberculosis; Arthritis, Rheumatoid; Brain Diseases; Clostridium Infections; Cryptosporidiosis; Dyspepsia; Enterocolitis, Pseudomembranous; Helicobacter Infections; Influenza, Human; Peritonitis; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Amebiasis; Diarrhea Pyruvate:ferredoxin oxidoreductase inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER; PEDIATRICS

ORAL

HIV Infections; Irritable Bowel Syndrome; Kidney Diseases; Liver Diseases; Bronchiolitis; Crohn Disease; Diabetes Mellitus, Type 2; Gastroenteritis; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Malnutrition; Periodontitis; Sexually Transmitted Diseases; Tuberculosis; Arthritis, Rheumatoid; Brain Diseases; Clostridium Infections; Cryptosporidiosis; Dyspepsia; Enterocolitis, Pseudomembranous; Helicobacter Infections; Influenza, Human; Peritonitis; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Amebiasis; Diarrhea

Pyruvate:ferredoxin oxidoreductase inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Hepatitis, Chronic; Cytomegalovirus Infections; HIV Infections; Hepatitis B, Chronic; Virus Diseases DNA polymerase/reverse transcriptase inhibitor


Small molecule Approved OTHER ORAL HIV Infections; Prostatic Neoplasms, Castration-Resistant; Hepatitis C, Chronic; Hepatitis D; Non-alcoholic Fatty Liver Disease; Aortic Valve Stenosis; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Metabolic Syndrome; Metabolism, Inborn Errors; Myocardial Infarction; Cardiovascular Diseases; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II Niemann-Pick C1-like protein 1 inhibitor

Small molecule

Approved

OTHER

ORAL

HIV Infections; Prostatic Neoplasms, Castration-Resistant; Hepatitis C, Chronic; Hepatitis D; Non-alcoholic Fatty Liver Disease; Aortic Valve Stenosis; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Metabolic Syndrome; Metabolism, Inborn Errors; Myocardial Infarction; Cardiovascular Diseases; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II

Niemann-Pick C1-like protein 1 inhibitor


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Diabetes Mellitus, Type 2; Atrial Fibrillation; Breast Neoplasms; Central Serous Chorioretinopathy; Diabetic Nephropathies; Hyperparathyroidism, Primary; Cardiomyopathies; Essential Hypertension; Muscular Dystrophy, Duchenne; Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Stroke Mineralocorticoid receptor antagonist

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Diabetes Mellitus, Type 2; Atrial Fibrillation; Breast Neoplasms; Central Serous Chorioretinopathy; Diabetic Nephropathies; Hyperparathyroidism, Primary; Cardiomyopathies; Essential Hypertension; Muscular Dystrophy, Duchenne; Renal Insufficiency, Chronic; Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Stroke

Mineralocorticoid receptor antagonist


Small molecule Approved OTHER INTRAMUSCULAR; ORAL; ORALLY DISINTEGRATING Amphetamine-Related Disorders; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Fragile X Syndrome; Obsessive-Compulsive Disorder; Trichotillomania; Alcoholism; Alzheimer Disease; Anorexia Nervosa; Anxiety; Child Development Disorders, Pervasive; Dementia; Depression, Postpartum; Mental Disorders; Stress Disorders, Post-Traumatic; Tic Disorders; Aggression; Autistic Disorder; Bipolar Disorder; Depressive Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia; Tourette Syndrome Dopamine D2 receptor partial agonist

Small molecule

Approved

OTHER

INTRAMUSCULAR; ORAL; ORALLY DISINTEGRATING

Amphetamine-Related Disorders; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Fragile X Syndrome; Obsessive-Compulsive Disorder; Trichotillomania; Alcoholism; Alzheimer Disease; Anorexia Nervosa; Anxiety; Child Development Disorders, Pervasive; Dementia; Depression, Postpartum; Mental Disorders; Stress Disorders, Post-Traumatic; Tic Disorders; Aggression; Autistic Disorder; Bipolar Disorder; Depressive Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia; Tourette Syndrome

Dopamine D2 receptor partial agonist


Small molecule Approved IMMUNE SYSTEM; OTHER INJECTION; INTRAVENOUS; IV (INFUSION); ORAL Asthma; Graft vs Host Disease; Hematologic Neoplasms; HIV Infections; Keratitis; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms; Neutropenia; Aspergillosis, Allergic Bronchopulmonary; Myelodysplastic Syndromes; Candidiasis, Invasive; Leishmaniasis; Leukemia; Leukemia, Myeloid, Acute; Neuroaspergillosis; Aspergillosis; Bacterial Infections and Mycoses; Candidemia; Candidiasis; Fusariosis; Infections; Mycoses Cytochrome P450 51 inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION); ORAL

Asthma; Graft vs Host Disease; Hematologic Neoplasms; HIV Infections; Keratitis; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms; Neutropenia; Aspergillosis, Allergic Bronchopulmonary; Myelodysplastic Syndromes; Candidiasis, Invasive; Leishmaniasis; Leukemia; Leukemia, Myeloid, Acute; Neuroaspergillosis; Aspergillosis; Bacterial Infections and Mycoses; Candidemia; Candidiasis; Fusariosis; Infections; Mycoses

Cytochrome P450 51 inhibitor


Unknown Approved OTHER INTRAPERITONEAL Kidney Failure, Chronic; Renal Insufficiency, Chronic; Heart Failure Osmotic agent


Small molecule Approved OTHER ORAL Common Cold; Infections; Respiratory Tract Infections; Cough; Fever; Headache; Sinusitis Unknown


Small molecule Approved OTHER TOPICAL Candidiasis, Vulvovaginal; Tinea Pedis Cytochrome P450 51 inhibitor


Small molecule Approved OTHER ORAL Unknown Voltage-gated L-type calcium channel blocker


Small molecule Approved OTHER INTRAVENOUS; IV (INFUSION) Meningitis; Renal Insufficiency, Chronic; Sepsis; Hematologic Neoplasms; Meningitis, Pneumococcal; Cross Infection; Diabetic Foot; Osteomyelitis; Pneumonia, Bacterial; Renal Insufficiency; Skin Diseases; Staphylococcal Infections; Bacteremia; Bacterial Infections; Endocarditis; Endocarditis, Bacterial; Gram-Positive Bacterial Infections; Infections; Skin Diseases, Bacterial; Soft Tissue Infections Cell membrane inhibitor

Small molecule

Approved

OTHER

INTRAVENOUS; IV (INFUSION)

Meningitis; Renal Insufficiency, Chronic; Sepsis; Hematologic Neoplasms; Meningitis, Pneumococcal; Cross Infection; Diabetic Foot; Osteomyelitis; Pneumonia, Bacterial; Renal Insufficiency; Skin Diseases; Staphylococcal Infections; Bacteremia; Bacterial Infections; Endocarditis; Endocarditis, Bacterial; Gram-Positive Bacterial Infections; Infections; Skin Diseases, Bacterial; Soft Tissue Infections

Cell membrane inhibitor


Protein Approved DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER SUBCUTANEOUS Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Prostatic Neoplasms; Sarcoma; Fibrous Dysplasia, Polyostotic; Pituitary Diseases; Acromegaly Growth hormone receptor antagonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; RESPIRATORY ORAL Astrocytoma; Depressive Disorder, Major; Glioblastoma; Head and Neck Neoplasms; Heart Failure; Muscular Dystrophies; Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cushing Syndrome; Dementia, Vascular; Diabetes Mellitus, Type 2; Eisenmenger Complex; Essential Hypertension; Gastroparesis; Hypertension; Multiple Myeloma; Obesity; Pancreatic Neoplasms; Priapism; Scleroderma, Systemic; Sexual Dysfunction, Physiological; Stroke; Glucose Intolerance; Heart Defects, Congenital; Insulin Resistance; Lung Diseases, Interstitial; Muscular Dystrophy, Duchenne; Premature Ejaculation; Raynaud Disease; Transposition of Great Vessels; Erectile Dysfunction; Hypertension, Pulmonary; Prostatic Hyperplasia; Pulmonary Arterial Hypertension Phosphodiesterase 5A inhibitor

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; RESPIRATORY

ORAL

Astrocytoma; Depressive Disorder, Major; Glioblastoma; Head and Neck Neoplasms; Heart Failure; Muscular Dystrophies; Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cushing Syndrome; Dementia, Vascular; Diabetes Mellitus, Type 2; Eisenmenger Complex; Essential Hypertension; Gastroparesis; Hypertension; Multiple Myeloma; Obesity; Pancreatic Neoplasms; Priapism; Scleroderma, Systemic; Sexual Dysfunction, Physiological; Stroke; Glucose Intolerance; Heart Defects, Congenital; Insulin Resistance; Lung Diseases, Interstitial; Muscular Dystrophy, Duchenne; Premature Ejaculation; Raynaud Disease; Transposition of Great Vessels; Erectile Dysfunction; Hypertension, Pulmonary; Prostatic Hyperplasia; Pulmonary Arterial Hypertension

Phosphodiesterase 5A inhibitor


Enzyme Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER; UROLOGY AND KIDNEY INTRAVENOUS Fabry Disease Globotriosylceramide hydrolytic enzyme


Small molecule Approved OTHER ORAL Diarrhea; Neuronal Ceroid-Lipofuscinoses; Cystic Fibrosis; HIV Infections; Spastic Paraplegia, Hereditary; Gangliosidoses, GM2; Glycogen Storage Disease; Niemann-Pick Disease, Type C; Sandhoff Disease; Gaucher Disease; Glycogen Storage Disease Type II; Niemann-Pick Diseases Ceramide glucosyltransferase inhibitor


Small molecule Approved OTHER ORAL Angioedema; Conjunctivitis, Allergic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor; Urticaria Histamine H1 receptor antagonist


Small molecule Approved OTHER ORAL Hepatitis C; Insulin Resistance; Tuberculosis; Liver Cirrhosis, Biliary; Multiple Sclerosis; Acquired Immunodeficiency Syndrome; Hepatitis B, Chronic; Infections; Severe Acute Respiratory Syndrome; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Small molecule

Approved

CANCER; GASTROINTESTINAL; OTHER

INTRAVENOUS; ORAL

Glioblastoma; Heroin Dependence; HIV Infections; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Dysmenorrhea; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Vomiting

Neurokinin 1 receptor antagonist


Protein Approved OTHER INTRAVENOUS Obsessive-Compulsive Disorder; Autistic Disorder Secretin receptor agonist


Small molecule Approved IMMUNE SYSTEM; OTHER; RESPIRATORY ORAL Asthma; Maxillary Sinusitis; Otitis Media; Otitis Media, Suppurative; Scrub Typhus; Bacterial Infections; Bronchitis, Chronic; Community-Acquired Infections; Infections; Pharyngitis; Pneumonia; Pneumonia, Bacterial; Sinusitis; Tonsillitis Bacterial 70S ribosome inhibitor

Antibody

Approved

OTHER; UROLOGY AND KIDNEY

INTRAVENOUS

Adenomatous Polyposis Coli; Carcinoma, Merkel Cell; Carcinoma, Pancreatic Ductal; Cystadenoma, Serous; Desmoplastic Small Round Cell Tumor; Diabetic Neuropathies; Endometriosis; Inflammatory Breast Neoplasms; Lymphedema; Meningitis, Aseptic; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms, Cystic, Mucinous, and Serous; Neuroma, Acoustic; Neuromyelitis Optica; Pharyngeal Neoplasms; Pulmonary Veno-Occlusive Disease; Renal Insufficiency, Chronic; von Hippel-Lindau Disease; Adenocarcinoma, Clear Cell; Adenoma; Adrenal Cortex Neoplasms; Ascites; Astrocytoma; Biliary Tract Neoplasms; Brain Injuries; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Endometrioid; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Central Serous Chorioretinopathy; Cholangiocarcinoma; Choriocarcinoma; Coronavirus Infections; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Gallbladder Neoplasms; Gestational Trophoblastic Disease; Glioma; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hemangiosarcoma; Hemorrhage; Histiocytoma, Benign Fibrous; Hodgkin Disease; Insulinoma; Keloid; Leiomyosarcoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Meningioma; Multiple Myeloma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Plasma Cell; Neurilemmoma; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Oligodendroglioma; Optic Neuropathy, Ischemic; Osteosarcoma; Papilloma; Pinealoma; Pneumonia; Primary Myelofibrosis; Pulmonary Fibrosis; Retroviridae Infections; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Kaposi; Sarcoma, Synovial; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Somatostatinoma; Thymoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Trophoblastic Tumor, Placental Site; Urinary Bladder Neoplasms; Uterine Neoplasms; Uveal Melanoma; Vascular Diseases; Vitreous Hemorrhage; Adenocarcinoma; Adenocarcinoma of Lung; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Choroidal Neovascularization; Choroiditis; Colorectal Neoplasms, Hereditary Nonpolyposis; Corneal Neovascularization; Diabetic Retinopathy; Gastrointestinal Stromal Tumors; Glaucoma; Gliosarcoma; Inflammation; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Follicular; Macular Degeneration; Macular Edema; Mesothelioma; Myopia; Pancreatic Neoplasms; Paraganglioma; Pleural Effusion; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pterygium; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retinal Detachment; Retinal Diseases; Retinal Telangiectasis; Retinal Vein Occlusion; Retinopathy of Prematurity; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis; Uveitis; Uveomeningoencephalitic Syndrome; Wet Macular Degeneration; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Retinal Neovascularization; Uterine Cervical Neoplasms

Vascular endothelial growth factor A inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

ORAL

Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Renal Insufficiency, Chronic; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections

Bacterial DNA-directed RNA polymerase inhibitor

Small molecule

Approved

EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Carcinoma, Squamous Cell; Cough; Essential Tremor; Marijuana Abuse; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Tobacco Use Disorder; Alcoholism; Complex Regional Pain Syndromes; Dental Anxiety; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Breast Neoplasms; Burning Mouth Syndrome; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Headache; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Anxiety Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries

Voltage-gated calcium channel modulator

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS; SUBCUTANEOUS

Acute Kidney Injury; Blastic Plasmacytoid Dendritic Cell Neoplasm; Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Mastocytosis, Systemic; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Sarcoma; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Lymphoma, Follicular; Melanoma; Multiple Myeloma; Myeloproliferative Disorders; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Thrombocytopenia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor