DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 1496


Protein Approved OTHER SUBCUTANEOUS Hypogonadism; Infertility; Infertility, Female; Ovulation Induction Luteinizing hormone/Choriogonadotropin receptor agonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Marijuana Abuse; Anxiety Disorders; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Renal Insufficiency, Chronic; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections Bacterial DNA-directed RNA polymerase inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

ORAL

Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Renal Insufficiency, Chronic; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections

Bacterial DNA-directed RNA polymerase inhibitor


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms Dihydrofolate reductase inhibitor

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Chordoma; Endometrial Neoplasms; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Primary Myelofibrosis; Thymoma; Thymus Neoplasms; Triple Negative Breast Neoplasms; Uveal Melanoma; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Large Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningeal Carcinomatosis; Mesothelioma, Malignant; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms

Dihydrofolate reductase inhibitor


Enzyme Approved OTHER INJECTION Anemia, Hemolytic; Diabetes Mellitus, Type 1; Hypersensitivity; Neuralgia; Breast Neoplasms; Graves Ophthalmopathy; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Melanoma; Muscle Spasticity; Neoplasms; Prostatic Neoplasms; Amyloidosis, Familial; Bursitis; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Lymphoma; Lymphoma, Follicular; Multiple Myeloma; Myocardial Infarction; Myocardial Ischemia; Pain Hyaluronic acid hydrolytic enzyme

Enzyme

Approved

OTHER

INJECTION

Anemia, Hemolytic; Diabetes Mellitus, Type 1; Hypersensitivity; Neuralgia; Breast Neoplasms; Graves Ophthalmopathy; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Melanoma; Muscle Spasticity; Neoplasms; Prostatic Neoplasms; Amyloidosis, Familial; Bursitis; Carcinoma, Non-Small-Cell Lung; Coronary Disease; Lymphoma; Lymphoma, Follicular; Multiple Myeloma; Myocardial Infarction; Myocardial Ischemia; Pain

Hyaluronic acid hydrolytic enzyme


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS; SUBCUTANEOUS Acute Kidney Injury; Blastic Plasmacytoid Dendritic Cell Neoplasm; Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Mastocytosis, Systemic; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Sarcoma; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Lymphoma, Follicular; Melanoma; Multiple Myeloma; Myeloproliferative Disorders; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Thrombocytopenia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS; SUBCUTANEOUS

Acute Kidney Injury; Blastic Plasmacytoid Dendritic Cell Neoplasm; Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Glioma; Graft vs Host Disease; Head and Neck Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Large Granular Lymphocytic; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Mastocytosis, Systemic; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Sarcoma; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Lymphoma, Follicular; Melanoma; Multiple Myeloma; Myeloproliferative Disorders; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Thrombocytopenia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor


Antibody Approved OTHER; UROLOGY AND KIDNEY INTRAVENOUS Adenomatous Polyposis Coli; Carcinoma, Merkel Cell; Carcinoma, Pancreatic Ductal; Cystadenoma, Serous; Desmoplastic Small Round Cell Tumor; Diabetic Neuropathies; Endometriosis; Inflammatory Breast Neoplasms; Lymphedema; Meningitis, Aseptic; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms, Cystic, Mucinous, and Serous; Neuroma, Acoustic; Neuromyelitis Optica; Pharyngeal Neoplasms; Pulmonary Veno-Occlusive Disease; Renal Insufficiency, Chronic; von Hippel-Lindau Disease; Adenocarcinoma, Clear Cell; Adenoma; Adrenal Cortex Neoplasms; Ascites; Astrocytoma; Biliary Tract Neoplasms; Brain Injuries; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Endometrioid; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Central Serous Chorioretinopathy; Cholangiocarcinoma; Choriocarcinoma; Coronavirus Infections; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Gallbladder Neoplasms; Gestational Trophoblastic Disease; Glioma; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hemangiosarcoma; Hemorrhage; Histiocytoma, Benign Fibrous; Hodgkin Disease; Insulinoma; Keloid; Leiomyosarcoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Meningioma; Multiple Myeloma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Plasma Cell; Neurilemmoma; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Oligodendroglioma; Optic Neuropathy, Ischemic; Osteosarcoma; Papilloma; Pinealoma; Pneumonia; Primary Myelofibrosis; Pulmonary Fibrosis; Retroviridae Infections; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Kaposi; Sarcoma, Synovial; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Somatostatinoma; Thymoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Trophoblastic Tumor, Placental Site; Urinary Bladder Neoplasms; Uterine Neoplasms; Uveal Melanoma; Vascular Diseases; Vitreous Hemorrhage; Adenocarcinoma; Adenocarcinoma of Lung; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Choroidal Neovascularization; Choroiditis; Colorectal Neoplasms, Hereditary Nonpolyposis; Corneal Neovascularization; Diabetic Retinopathy; Gastrointestinal Stromal Tumors; Glaucoma; Gliosarcoma; Inflammation; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Follicular; Macular Degeneration; Macular Edema; Mesothelioma; Myopia; Pancreatic Neoplasms; Paraganglioma; Pleural Effusion; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pterygium; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retinal Detachment; Retinal Diseases; Retinal Telangiectasis; Retinal Vein Occlusion; Retinopathy of Prematurity; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis; Uveitis; Uveomeningoencephalitic Syndrome; Wet Macular Degeneration; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Retinal Neovascularization; Uterine Cervical Neoplasms Vascular endothelial growth factor A inhibitor

Antibody

Approved

OTHER; UROLOGY AND KIDNEY

INTRAVENOUS

Adenomatous Polyposis Coli; Carcinoma, Merkel Cell; Carcinoma, Pancreatic Ductal; Cystadenoma, Serous; Desmoplastic Small Round Cell Tumor; Diabetic Neuropathies; Endometriosis; Inflammatory Breast Neoplasms; Lymphedema; Meningitis, Aseptic; Myeloproliferative Disorders; Neoplasm Metastasis; Neoplasms, Cystic, Mucinous, and Serous; Neuroma, Acoustic; Neuromyelitis Optica; Pharyngeal Neoplasms; Pulmonary Veno-Occlusive Disease; Renal Insufficiency, Chronic; von Hippel-Lindau Disease; Adenocarcinoma, Clear Cell; Adenoma; Adrenal Cortex Neoplasms; Ascites; Astrocytoma; Biliary Tract Neoplasms; Brain Injuries; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Endometrioid; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Central Serous Chorioretinopathy; Cholangiocarcinoma; Choriocarcinoma; Coronavirus Infections; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Gallbladder Neoplasms; Gestational Trophoblastic Disease; Glioma; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hemangiosarcoma; Hemorrhage; Histiocytoma, Benign Fibrous; Hodgkin Disease; Insulinoma; Keloid; Leiomyosarcoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Meningioma; Multiple Myeloma; Myelodysplastic Syndromes; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neoplasms, Plasma Cell; Neurilemmoma; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Oligodendroglioma; Optic Neuropathy, Ischemic; Osteosarcoma; Papilloma; Pinealoma; Pneumonia; Primary Myelofibrosis; Pulmonary Fibrosis; Retroviridae Infections; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Kaposi; Sarcoma, Synovial; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Somatostatinoma; Thymoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Trophoblastic Tumor, Placental Site; Urinary Bladder Neoplasms; Uterine Neoplasms; Uveal Melanoma; Vascular Diseases; Vitreous Hemorrhage; Adenocarcinoma; Adenocarcinoma of Lung; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Ovarian Epithelial; Choroidal Neovascularization; Choroiditis; Colorectal Neoplasms, Hereditary Nonpolyposis; Corneal Neovascularization; Diabetic Retinopathy; Gastrointestinal Stromal Tumors; Glaucoma; Gliosarcoma; Inflammation; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Follicular; Macular Degeneration; Macular Edema; Mesothelioma; Myopia; Pancreatic Neoplasms; Paraganglioma; Pleural Effusion; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pterygium; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retinal Detachment; Retinal Diseases; Retinal Telangiectasis; Retinal Vein Occlusion; Retinopathy of Prematurity; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis; Uveitis; Uveomeningoencephalitic Syndrome; Wet Macular Degeneration; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Retinal Neovascularization; Uterine Cervical Neoplasms

Vascular endothelial growth factor A inhibitor


Small molecule Approved OTHER INHALATION Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis Prostanoid IP receptor agonist

Small molecule

Approved

OTHER

INHALATION

Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis

Prostanoid IP receptor agonist


Protein Approved OTHER INTRAVENOUS Obsessive-Compulsive Disorder; Autistic Disorder Secretin receptor agonist


Small molecule Approved EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Carcinoma, Squamous Cell; Cough; Essential Tremor; Marijuana Abuse; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Tobacco Use Disorder; Alcoholism; Complex Regional Pain Syndromes; Dental Anxiety; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Breast Neoplasms; Burning Mouth Syndrome; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Headache; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Anxiety Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries Voltage-gated calcium channel modulator

Small molecule

Approved

EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Carcinoma, Squamous Cell; Cough; Essential Tremor; Marijuana Abuse; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Tobacco Use Disorder; Alcoholism; Complex Regional Pain Syndromes; Dental Anxiety; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Breast Neoplasms; Burning Mouth Syndrome; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Headache; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Anxiety Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries

Voltage-gated calcium channel modulator


Small molecule Approved OTHER; UROLOGY AND KIDNEY ORAL Pulmonary Disease, Chronic Obstructive; Schizophrenia; Urinary Bladder, Overactive; Urinary Incontinence, Urge Muscarinic acetylcholine receptor M2 antagonist


Small molecule Approved OTHER OPHTHALMIC Unknown Diagnostic


Small molecule Approved OTHER OPHTHALMIC Macular Edema; Miosis; Cataract; Eye Diseases; Inflammation; Ophthalmologic Surgical Procedures; Pain, Postoperative Cyclooxygenase inhibitor


Small molecule Approved OTHER; PEDIATRICS ORAL Hemorrhage; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER ORAL Liver Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Anemia; Hemochromatosis; Leukemia, Myeloid, Acute; Mucormycosis; Osteoporosis, Postmenopausal; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Hemosiderosis; Porphyria Cutanea Tarda; Thalassemia; beta-Thalassemia; Iron Overload; Myelodysplastic Syndromes Iron chelating agent


Protein Approved OTHER INJECTION Cystic Fibrosis; Atherosclerosis; Coronary Disease; Hypercholesterolemia; Hypertension; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 Insulin receptor agonist


Protein Approved OTHER INJECTION Alopecia; Epidermolysis Bullosa; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Plasma Cell; Lymphoma, Non-Hodgkin; Multiple Sclerosis; Neoplasms, Neuroepithelial; Stevens-Johnson Syndrome; X-Linked Combined Immunodeficiency Diseases; Asthma; Colonic Neoplasms; HIV Infections; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Myelodysplastic Syndromes; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Leukemia; Lymphoma; Multiple Myeloma; Neoplasms; Mucositis; Stomatitis Fibroblast growth factor receptor 2 agonist

Protein

Approved

OTHER

INJECTION

Alopecia; Epidermolysis Bullosa; Graft vs Host Disease; Granulomatous Disease, Chronic; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Plasma Cell; Lymphoma, Non-Hodgkin; Multiple Sclerosis; Neoplasms, Neuroepithelial; Stevens-Johnson Syndrome; X-Linked Combined Immunodeficiency Diseases; Asthma; Colonic Neoplasms; HIV Infections; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Myelodysplastic Syndromes; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Leukemia; Lymphoma; Multiple Myeloma; Neoplasms; Mucositis; Stomatitis

Fibroblast growth factor receptor 2 agonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Neuralgia; Epilepsy; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Low Back Pain; Pain; Schizophrenia; Anxiety; Lennox Gastaut Syndrome; Seizures GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Colorectal Neoplasms; Hepatitis C, Chronic; Hepatitis D; Infections; Liver Failure; Liver Neoplasms; Stomach Neoplasms; Carcinoma, Hepatocellular; Hepatitis B; Hepatitis B, Chronic; Liver Diseases; Virus Diseases DNA polymerase/reverse transcriptase inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Marijuana Abuse; Burns; Migraine with Aura; Migraine without Aura; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Depressive Disorder; Sleep Wake Disorders; Sleep Initiation and Maintenance Disorders Melatonin receptor agonist

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Marijuana Abuse; Burns; Migraine with Aura; Migraine without Aura; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Depressive Disorder; Sleep Wake Disorders; Sleep Initiation and Maintenance Disorders

Melatonin receptor agonist


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Lymphoma, Primary Effusion; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Autistic Disorder; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Neoplasms, Plasma Cell; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Lymphoma, Primary Effusion; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Autistic Disorder; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Immunoglobulin Light-chain Amyloidosis; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphoid; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Neoplasms, Plasma Cell; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved GASTROINTESTINAL; OTHER ORAL HIV Infections; Chronic Pain; Constipation; Irritable Bowel Syndrome Chloride channel protein 2 opener


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS Burkitt Lymphoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hematologic Neoplasms; HIV Infections; Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Mastocytosis, Systemic; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma, Synovial; Triple Negative Breast Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Anemia, Sickle Cell; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Esophageal Neoplasms; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lung Neoplasms; Lymphoma; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Primary Myelofibrosis; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Hematologic Diseases; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS

Burkitt Lymphoma; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hematologic Neoplasms; HIV Infections; Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Mastocytosis, Systemic; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Paraganglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Sarcoma, Synovial; Triple Negative Breast Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Anemia, Sickle Cell; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Esophageal Neoplasms; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lung Neoplasms; Lymphoma; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Primary Myelofibrosis; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Hematologic Diseases; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myeloid; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor


Antibody Approved CANCER; OTHER IV (INFUSION) Brain Neoplasms; Glioma; Kidney Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms Epidermal growth factor receptor erbB1 inhibitor

Antibody

Approved

CANCER; OTHER

IV (INFUSION)

Brain Neoplasms; Glioma; Kidney Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Obsessive-Compulsive Disorder; Anxiety; Autistic Disorder; Bipolar Disorder; Dementia; Depressive Disorder; Mood Disorders; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist


Small molecule Approved CANCER; OTHER ORAL Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma Bcr/Abl fusion protein inhibitor


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Autoimmune Diseases; HIV Infections; Infections Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER ORAL Amyotrophic Lateral Sclerosis; Hepatitis C; Insulin Resistance; Acquired Immunodeficiency Syndrome; Infections; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER; PEDIATRICS; RESPIRATORY INHALATION; NASAL Pulmonary Disease, Chronic Obstructive; Chronic Disease; Hypersensitivity; Respiratory Tract Diseases; Severe Acute Respiratory Syndrome; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal Glucocorticoid receptor agonist


Small molecule Approved IMMUNE SYSTEM; OTHER INJECTION; INTRAVENOUS Mycoses; Neutropenia; Leukemia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms; Aspergillosis; Candidiasis, Invasive; Neuroaspergillosis; Candidemia; Candidiasis; Peritonitis 1,3-beta-glucan synthase inhibitor


Enzyme Approved OTHER; PEDIATRICS IV (INFUSION) Glycogen Storage Disease; Glycogen Storage Disease Type II Starch hydrolytic enzyme


Small molecule Approved IMMUNE SYSTEM; OTHER INTRAVENOUS; ORAL Glioblastoma; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Chagas Disease; Granulomatous Disease, Chronic; Mucormycosis; Onychomycosis; Candidiasis, Oral; Leukopenia; Aspergillosis; Candidiasis; Coccidioidomycosis; Mycoses; Neutropenia Cytochrome P450 51 inhibitor

Small molecule

Approved

OTHER

ORAL

Alcohol Drinking; Alzheimer Disease; Amphetamine-Related Disorders; Cocaine-Related Disorders; Friedreich Ataxia; Machado-Joseph Disease; Marijuana Abuse; Parkinson Disease; Psychotic Disorders; Schizophrenia; Substance-Related Disorders; Acute Coronary Syndrome; Alcoholism; Dry Eye Syndromes; Lung Neoplasms; Neoplasms; Smoking Cessation; Eye Diseases; Tobacco Use Disorder

Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Hypertension, Pulmonary; Kidney Diseases; Myotonic Disorders; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Cardiomyopathy, Dilated; Crohn Disease; Heart Failure, Diastolic; Irritable Bowel Syndrome; Romano-Ward Syndrome; Vascular Diseases; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases

Sodium channel protein type IV alpha subunit blocker

Small molecule

Approved

OTHER

ORAL

Alzheimer Disease; Anus Neoplasms; Burkitt Lymphoma; Carcinoma, Ovarian Epithelial; Carcinoma, Squamous Cell; Carcinoma, Verrucous; Crohn Disease; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioma; Hypopharyngeal Neoplasms; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Juvenile; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Neoplasms, Plasma Cell; Niemann-Pick Diseases; Oligodendroglioma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Salivary Gland Neoplasms; Schizophrenia; Skin Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Adenocarcinoma, Follicular; Anemia, Sickle Cell; Astrocytoma; Brain Diseases; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Gliosarcoma; HIV Infections; Hodgkin Disease; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Myelodysplastic Syndromes; Neuroblastoma; Ovarian Neoplasms; Pituitary ACTH Hypersecretion; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Sezary Syndrome; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uveal Melanoma; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Mesothelioma; Multiple Myeloma; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Neoplasms

Histone deacetylase 1 inhibitor