DrugMapper


Display Options: Drug type Therapeutic Area Route of administration Mechanism of Action Indication Status		Total: 1496


Protein Approved OTHER SUBCUTANEOUS Infertility, Female; Hypogonadism; Infertility Luteinizing hormone/Choriogonadotropin receptor agonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Marijuana Abuse; Anxiety Disorders; Sleep Apnea, Obstructive; Sleep Initiation and Maintenance Disorders GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Renal Insufficiency, Chronic; Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections Bacterial DNA-directed RNA polymerase inhibitor

Small molecule

Approved

IMMUNE SYSTEM; OTHER

ORAL

Renal Insufficiency, Chronic; Cholangitis, Sclerosing; Neoplasms; Persian Gulf Syndrome; Alzheimer Disease; Anemia, Sickle Cell; Breast Neoplasms; Diverticulitis; Dyspepsia; Heart Failure, Systolic; Hepatitis C; HIV Infections; Intestinal Pseudo-Obstruction; Rosacea; Vaginosis, Bacterial; Brain Diseases; Clostridium Infections; Colitis, Collagenous; Crohn Disease; Helicobacter Infections; Hepatitis, Alcoholic; Irritable Bowel Syndrome; Liver Cirrhosis; Parkinson Disease; Peritonitis; Rectal Neoplasms; Diarrhea; Hepatic Encephalopathy; Infections

Bacterial DNA-directed RNA polymerase inhibitor


Small molecule Approved CANCER; OTHER INJECTION; INTRAVENOUS; IV (INFUSION) Glioma; Chordoma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Meningeal Carcinomatosis; Thymoma; Thymus Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Medulloblastoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms Unknown

Small molecule

Approved

CANCER; OTHER

INJECTION; INTRAVENOUS; IV (INFUSION)

Glioma; Chordoma; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Meningeal Carcinomatosis; Thymoma; Thymus Neoplasms; Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Liver Neoplasms; Medulloblastoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neuroendocrine Tumors; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Thyroid Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Adenocarcinoma of Lung; Carcinoma; Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Mesothelioma; Neoplasms

Unknown


Enzyme Approved OTHER INJECTION Diabetes Mellitus, Type 1; Hypersensitivity; Graves Ophthalmopathy; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Melanoma; Muscle Spasticity; Neoplasms; Bursitis; Lymphoma, Follicular; Multiple Myeloma; Myocardial Infarction; Myocardial Ischemia; Pain Hyaluronic acid hydrolytic enzyme


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS; SUBCUTANEOUS Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Ovarian Neoplasms; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Glioma; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Thrombocytopenia DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS; SUBCUTANEOUS

Brain Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Ependymoma; Esophageal Neoplasms; Head and Neck Neoplasms; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Lymphoma, Non-Hodgkin; Myelodysplastic-Myeloproliferative Diseases; Osteosarcoma; Ovarian Neoplasms; Tuberculosis; beta-Thalassemia; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Glioma; Hematologic Neoplasms; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Melanoma; Multiple Myeloma; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Immunoblastic Lymphadenopathy; Leukemia; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms; Thrombocytopenia

DNA (cytosine-5)-methyltransferase 1 inhibitor


Antibody Approved OTHER; UROLOGY AND KIDNEY INTRAVENOUS Desmoplastic Small Round Cell Tumor; Pharyngeal Neoplasms; Renal Insufficiency, Chronic; von Hippel-Lindau Disease; Carcinoma, Merkel Cell; Carcinoma, Pancreatic Ductal; Cystadenoma, Serous; Diabetic Neuropathies; Endometriosis; Inflammatory Breast Neoplasms; Lymphedema; Meningitis, Aseptic; Myeloproliferative Disorders; Neoplasm Metastasis; Neuromyelitis Optica; Pulmonary Veno-Occlusive Disease; Adenocarcinoma, Clear Cell; Adenoma; Adrenal Cortex Neoplasms; Ascites; Astrocytoma; Biliary Tract Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Central Serous Chorioretinopathy; Cholangiocarcinoma; Choriocarcinoma; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hemangiosarcoma; Hemorrhage; Histiocytoma, Benign Fibrous; Hodgkin Disease; Insulinoma; Keloid; Leiomyosarcoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Meningioma; Multiple Myeloma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Oligodendroglioma; Optic Neuropathy, Ischemic; Papilloma; Pinealoma; Pneumonia; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Pulmonary Fibrosis; Retroviridae Infections; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial; Severe Acute Respiratory Syndrome; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Somatostatinoma; Spinal Cord Neoplasms; Thymoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Trophoblastic Tumor, Placental Site; Urinary Bladder Neoplasms; Vascular Diseases; Vitreous Hemorrhage; Adenocarcinoma; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Signet Ring Cell; Choroiditis; Colorectal Neoplasms, Hereditary Nonpolyposis; Corneal Neovascularization; Diabetic Retinopathy; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Glaucoma; Gliosarcoma; Inflammation; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Follicular; Macular Degeneration; Macular Edema; Mesothelioma; Myopia; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Pleural Effusion; Prostatic Neoplasms; Pterygium; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retinal Detachment; Retinal Diseases; Retinal Vein Occlusion; Retinopathy of Prematurity; Stomach Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis; Uveitis; Uveomeningoencephalitic Syndrome; Wet Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Neoplasms; Uterine Cervical Neoplasms Vascular endothelial growth factor A inhibitor

Antibody

Approved

OTHER; UROLOGY AND KIDNEY

INTRAVENOUS

Desmoplastic Small Round Cell Tumor; Pharyngeal Neoplasms; Renal Insufficiency, Chronic; von Hippel-Lindau Disease; Carcinoma, Merkel Cell; Carcinoma, Pancreatic Ductal; Cystadenoma, Serous; Diabetic Neuropathies; Endometriosis; Inflammatory Breast Neoplasms; Lymphedema; Meningitis, Aseptic; Myeloproliferative Disorders; Neoplasm Metastasis; Neuromyelitis Optica; Pulmonary Veno-Occlusive Disease; Adenocarcinoma, Clear Cell; Adenoma; Adrenal Cortex Neoplasms; Ascites; Astrocytoma; Biliary Tract Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoid Tumor; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Central Serous Chorioretinopathy; Cholangiocarcinoma; Choriocarcinoma; Diffuse Intrinsic Pontine Glioma; Digestive System Diseases; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hemangiosarcoma; Hemorrhage; Histiocytoma, Benign Fibrous; Hodgkin Disease; Insulinoma; Keloid; Leiomyosarcoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liposarcoma; Liver Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Meningioma; Multiple Myeloma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Oligodendroglioma; Optic Neuropathy, Ischemic; Papilloma; Pinealoma; Pneumonia; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Pulmonary Fibrosis; Retroviridae Infections; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Kaposi; Sarcoma, Synovial; Severe Acute Respiratory Syndrome; Sex Cord-Gonadal Stromal Tumors; Small Cell Lung Carcinoma; Somatostatinoma; Spinal Cord Neoplasms; Thymoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Trophoblastic Tumor, Placental Site; Urinary Bladder Neoplasms; Vascular Diseases; Vitreous Hemorrhage; Adenocarcinoma; Adenocarcinoma of Lung; Breast Neoplasms; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Signet Ring Cell; Choroiditis; Colorectal Neoplasms, Hereditary Nonpolyposis; Corneal Neovascularization; Diabetic Retinopathy; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Glaucoma; Gliosarcoma; Inflammation; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Follicular; Macular Degeneration; Macular Edema; Mesothelioma; Myopia; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Pleural Effusion; Prostatic Neoplasms; Pterygium; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Retinal Detachment; Retinal Diseases; Retinal Vein Occlusion; Retinopathy of Prematurity; Stomach Neoplasms; Telangiectasia, Hereditary Hemorrhagic; Telangiectasis; Uveitis; Uveomeningoencephalitic Syndrome; Wet Macular Degeneration; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Neoplasms; Uterine Cervical Neoplasms

Vascular endothelial growth factor A inhibitor


Small molecule Approved OTHER INHALATION Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis Prostanoid IP receptor agonist

Small molecule

Approved

OTHER

INHALATION

Asthma; Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis

Prostanoid IP receptor agonist


Protein Approved OTHER INTRAVENOUS Obsessive-Compulsive Disorder; Autistic Disorder Secretin receptor agonist


Small molecule Approved EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Essential Tremor; Marijuana Abuse; Tobacco Use Disorder; Carcinoma, Squamous Cell; Cough; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Alcoholism; Complex Regional Pain Syndromes; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Anxiety Disorders; Breast Neoplasms; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries Voltage-gated calcium channel modulator

Small molecule

Approved

EMERGENCY MEDICINE; MUSCULOSKELETAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Essential Tremor; Marijuana Abuse; Tobacco Use Disorder; Carcinoma, Squamous Cell; Cough; Oropharyngeal Neoplasms; Pregnancy; Refractive Errors; Alcoholism; Complex Regional Pain Syndromes; Diabetes Mellitus; Dry Eye Syndromes; Irritable Bowel Syndrome; Nausea; Pancreatitis, Chronic; Pruritus; Urinary Bladder, Overactive; Anxiety; Anxiety Disorders; Breast Neoplasms; Chronic Pain; Dementia; Depressive Disorder; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Epilepsy, Tonic-Clonic; Fractures, Bone; Herpes Zoster; Intervertebral Disc Degeneration; Migraine Disorders; Mononeuropathies; Muscle Cramp; Neuralgia, Postherpetic; Neurotic Disorders; Opioid-Related Disorders; Osteoarthritis; Pain; Peripheral Nervous System Diseases; Prostatitis; Radiculopathy; Restless Legs Syndrome; Schizophrenia; Sleep Initiation and Maintenance Disorders; Epilepsy; Fibromyalgia; Neuralgia; Seizures; Spinal Cord Injuries

Voltage-gated calcium channel modulator


Small molecule Approved OTHER; UROLOGY AND KIDNEY ORAL Pulmonary Disease, Chronic Obstructive; Schizophrenia; Urinary Bladder, Overactive; Urinary Incontinence, Urge Muscarinic acetylcholine receptor M2 antagonist


Small molecule Approved OTHER OPHTHALMIC Unknown Unknown


Small molecule Approved OTHER OPHTHALMIC Macular Edema; Miosis; Cataract; Eye Diseases; Inflammation Cyclooxygenase inhibitor


Small molecule Approved OTHER; PEDIATRICS ORAL Hemorrhage; HIV Infections; Virus Diseases Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER ORAL Liver Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Anemia; Hemochromatosis; Leukemia, Myeloid, Acute; Mucormycosis; Osteoporosis, Postmenopausal; Anemia, Sickle Cell; beta-Thalassemia; Hemosiderosis; Porphyria Cutanea Tarda; Red-Cell Aplasia, Pure; Thalassemia; Myelodysplastic Syndromes Iron chelating agent


Protein Approved OTHER INJECTION Cystic Fibrosis; Atherosclerosis; Coronary Disease; Hypercholesterolemia; Hypertension; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 Insulin receptor agonist


Protein Approved OTHER INJECTION Alopecia; Neoplasms, Neuroepithelial; Graft vs Host Disease; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Plasma Cell; Lymphoma, Non-Hodgkin; Multiple Sclerosis; Stevens-Johnson Syndrome; X-Linked Combined Immunodeficiency Diseases; Asthma; Colonic Neoplasms; HIV Infections; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Myelodysplastic Syndromes; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Leukemia; Lymphoma; Multiple Myeloma; Neoplasms; Mucositis; Stomatitis Fibroblast growth factor receptor 2 agonist

Protein

Approved

OTHER

INJECTION

Alopecia; Neoplasms, Neuroepithelial; Graft vs Host Disease; Hematologic Neoplasms; Hodgkin Disease; Leukemia, Plasma Cell; Lymphoma, Non-Hodgkin; Multiple Sclerosis; Stevens-Johnson Syndrome; X-Linked Combined Immunodeficiency Diseases; Asthma; Colonic Neoplasms; HIV Infections; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Myelodysplastic Syndromes; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Leukemia; Lymphoma; Multiple Myeloma; Neoplasms; Mucositis; Stomatitis

Fibroblast growth factor receptor 2 agonist


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS ORAL Neuralgia; Epilepsy; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Epilepsies, Myoclonic; Low Back Pain; Pain; Schizophrenia; Anxiety; Lennox Gastaut Syndrome; Seizures GABA-A receptor; anion channel positive allosteric modulator


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Colorectal Neoplasms; Hepatitis C, Chronic; Hepatitis D; Liver Failure; Liver Neoplasms; Stomach Neoplasms; Carcinoma, Hepatocellular; Hepatitis B; Hepatitis B, Chronic; Liver Diseases; Virus Diseases DNA polymerase/reverse transcriptase inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Marijuana Abuse; Burns; Migraine with Aura; Migraine without Aura; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Sleep Wake Disorders; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Depressive Disorder; Sleep Initiation and Maintenance Disorders Melatonin receptor agonist

Small molecule

Approved

NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER

ORAL

Marijuana Abuse; Burns; Migraine with Aura; Migraine without Aura; Pulmonary Disease, Chronic Obstructive; Severe Acute Respiratory Syndrome; Sleep Apnea, Obstructive; Sleep Wake Disorders; Substance-Related Disorders; Tobacco Use Disorder; Bipolar Disorder; Depressive Disorder; Sleep Initiation and Maintenance Disorders

Melatonin receptor agonist


Small molecule Approved CANCER; HEMATOLOGY; OTHER ORAL Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Amyloidosis; Autistic Disorder; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes CRL4(CRBN) E3 ubiquitin ligase inhibitor

Small molecule

Approved

CANCER; HEMATOLOGY; OTHER

ORAL

Astrocytoma; Burkitt Lymphoma; Cachexia; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Fallopian Tube Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, B-Cell; Neoplasms; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Kaposi; Urethral Neoplasms; Amyloidosis; Autistic Disorder; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colorectal Neoplasms; Complex Regional Pain Syndromes; Crohn Disease; Glioma; Gliosarcoma; Graft vs Host Disease; Hematologic Diseases; Hematologic Neoplasms; Histiocytosis, Sinus; HIV Infections; Hodgkin Disease; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Plasma Cell; Leukemia, Prolymphocytic; Liver Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Pancreatic Neoplasms; POEMS Syndrome; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Radiculopathy; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Waldenstrom Macroglobulinemia; Amyloidosis, Familial; Epstein-Barr Virus Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Neoplasm Metastasis; Plasmacytoma; Prostatic Neoplasms, Castration-Resistant; Smoldering Multiple Myeloma; Anemia; Immune System Diseases; Lymphoma, Mantle-Cell; Multiple Myeloma; Myelodysplastic Syndromes

CRL4(CRBN) E3 ubiquitin ligase inhibitor


Small molecule Approved GASTROINTESTINAL; OTHER ORAL HIV Infections; Chronic Pain; Constipation; Irritable Bowel Syndrome Chloride channel protein 2 opener


Small molecule Approved HEMATOLOGY; OTHER INTRAVENOUS Lymphoma, Follicular; Anemia, Sickle Cell; Burkitt Lymphoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia, Promyelocytic, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Blast Crisis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms DNA (cytosine-5)-methyltransferase 1 inhibitor

Small molecule

Approved

HEMATOLOGY; OTHER

INTRAVENOUS

Lymphoma, Follicular; Anemia, Sickle Cell; Burkitt Lymphoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Leukemia, Promyelocytic, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous; Medulloblastoma; Multiple Myeloma; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Adenocarcinoma, Follicular; Anemia, Aplastic; Blast Crisis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Hodgkin Disease; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Melanoma; Ovarian Neoplasms; Peritoneal Neoplasms; Severe Acute Respiratory Syndrome; Thalassemia; Thyroid Neoplasms; Graft vs Host Disease; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Peripheral; Myeloproliferative Disorders; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Anemia; Anemia, Refractory, with Excess of Blasts; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Neoplasms

DNA (cytosine-5)-methyltransferase 1 inhibitor


Antibody Approved CANCER; OTHER IV (INFUSION) Kidney Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms Epidermal growth factor receptor erbB1 inhibitor

Antibody

Approved

CANCER; OTHER

IV (INFUSION)

Kidney Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholangiocarcinoma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Lung Neoplasms; Malignant Carcinoid Syndrome; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Neoplasms

Epidermal growth factor receptor erbB1 inhibitor


Small molecule Approved NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER ORAL Obsessive-Compulsive Disorder; Anxiety; Autistic Disorder; Bipolar Disorder; Dementia; Depressive Disorder; Psychotic Disorders; Schizophrenia Dopamine D2 receptor antagonist

Small molecule

Approved

CANCER; OTHER

ORAL

Endometrial Neoplasms; Alzheimer Disease; Brain Neoplasms; Burkitt Lymphoma; Central Nervous System Neoplasms; Colorectal Neoplasms; Fallopian Tube Neoplasms; Granuloma, Lethal Midline; Head and Neck Neoplasms; Hodgkin Disease; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Myeloid; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Myelodysplastic Syndromes; Ovarian Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma; Scleroderma, Localized; Sezary Syndrome; Waldenstrom Macroglobulinemia; Aging; Brain Diseases; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cholangiocarcinoma; Colonic Neoplasms; Diffuse Intrinsic Pontine Glioma; Gastrointestinal Stromal Tumors; Glioblastoma; Glioma; Gliosarcoma; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Mastocytosis, Systemic; Melanoma; Mesothelioma; Multiple Myeloma; Neuroblastoma; Pancreatic Neoplasms; Pinealoma; Polycythemia Vera; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Small Cell Lung Carcinoma; Leukemia; Leukemia, Myeloid, Acute; Prostatic Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

Bcr/Abl fusion protein


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Autoimmune Diseases; HIV Infections; Infections Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER ORAL Amyotrophic Lateral Sclerosis; Hepatitis C; Insulin Resistance; Acquired Immunodeficiency Syndrome; HIV Infections; Infections; Pneumonia, Pneumocystis; Severe Acute Respiratory Syndrome; Virus Diseases Human immunodeficiency virus type 1 protease inhibitor


Small molecule Approved OTHER; PEDIATRICS; RESPIRATORY INHALATION; NASAL Pulmonary Disease, Chronic Obstructive; Chronic Disease; Hypersensitivity; Severe Acute Respiratory Syndrome; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal Glucocorticoid receptor agonist


Small molecule Approved IMMUNE SYSTEM; OTHER INJECTION; INTRAVENOUS Mycoses; Neutropenia; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms; Aspergillosis; Candidiasis, Invasive; Neuroaspergillosis; Candidemia; Candidiasis; Peritonitis 1,3-beta-glucan synthase inhibitor


Enzyme Approved OTHER; PEDIATRICS IV (INFUSION) Glycogen Storage Disease; Glycogen Storage Disease Type II Starch hydrolytic enzyme


Small molecule Approved IMMUNE SYSTEM; OTHER INTRAVENOUS; ORAL Glioblastoma; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Chagas Disease; Granulomatous Disease, Chronic; Candidiasis, Oral; Coccidioidomycosis; Leukopenia; Mycoses; Aspergillosis; Candidiasis; Neutropenia Cytochrome P450 51 inhibitor

Small molecule

Approved

OTHER

ORAL

Alcohol Drinking; Alzheimer Disease; Amphetamine-Related Disorders; Cocaine-Related Disorders; Friedreich Ataxia; Machado-Joseph Disease; Marijuana Abuse; Parkinson Disease; Psychotic Disorders; Substance-Related Disorders; Acute Coronary Syndrome; Alcoholism; Lung Neoplasms; Neoplasms; Schizophrenia; Smoking Cessation; Tobacco Use Disorder

Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Hypertension, Pulmonary; Kidney Diseases; Myotonic Disorders; Acute Coronary Syndrome; Amyotrophic Lateral Sclerosis; Cardiomyopathy, Dilated; Crohn Disease; Heart Failure, Diastolic; Irritable Bowel Syndrome; Long QT Syndrome; Vascular Diseases; Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Myocardial Ischemia; Angina Pectoris; Angina, Stable; Cardiovascular Diseases

Sodium channel protein type IV alpha subunit blocker

Small molecule

Approved

OTHER

ORAL

Schizophrenia; Alzheimer Disease; Anus Neoplasms; Burkitt Lymphoma; Carcinoma, Verrucous; Crohn Disease; Diffuse Intrinsic Pontine Glioma; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioma; Hodgkin Disease; Hypopharyngeal Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Juvenile; Leukemia, Promyelocytic, Acute; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Niemann-Pick Diseases; Oligodendroglioma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Skin Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Anemia, Sickle Cell; Astrocytoma; Brain Diseases; Brain Neoplasms; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Glioblastoma; Gliosarcoma; HIV Infections; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Myelodysplastic Syndromes; Neuroblastoma; Ovarian Neoplasms; Pituitary ACTH Hypersecretion; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Sezary Syndrome; Spinal Cord Neoplasms; Thrombocythemia, Essential; Thyroid Neoplasms; Urinary Bladder Neoplasms; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Mesothelioma; Multiple Myeloma; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Neoplasms

Histone deacetylase 1 inhibitor