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Total: 1496
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER; PREGNANCY AND GYNECOLOGY; RHEUMATOLOGY
ORAL; TOPICAL; TRANSDERMAL; VAGINAL
Cerebral Arterial Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; HIV Infections; Osteoporosis; Polycystic Ovary Syndrome; Aging; Alzheimer Disease; Atherosclerosis; Bulimia Nervosa; Carcinoid Tumor; Depression, Postpartum; Depressive Disorder; Dry Eye Syndromes; Hereditary Breast and Ovarian Cancer Syndrome; Migraine Disorders; Prostatic Neoplasms; Psychotic Disorders; Schizophrenia; Severe Acute Respiratory Syndrome; Amenorrhea; Anorexia Nervosa; Atrophic Vaginitis; Atrophy; Bone Diseases, Metabolic; Breast Neoplasms; Dysmenorrhea; Endometriosis; Hot Flashes; Infertility; Leiomyoma; Menopause; Multiple Sclerosis; Myocardial Ischemia; Non-alcoholic Fatty Liver Disease; Obesity; Pain; Prostatic Neoplasms, Castration-Resistant; Sexual Dysfunction, Physiological; Stress Disorders, Post-Traumatic; Turner Syndrome; Dyspareunia; Hypogonadism; Primary Ovarian Insufficiency
Estrogen receptor alpha agonist
Small molecule
Approved
OTHER
TOPICAL
Dermatitis, Atopic; Lichen Planus, Oral; Periarthritis; Eye Diseases; Hemorrhoids; Infections; Lung Diseases, Obstructive; Nasal Obstruction; Psoriasis; Skin Diseases
Glucocorticoid receptor agonist
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER
INJECTION; INTRAMUSCULAR; SUBCUTANEOUS
Pregnancy; Premature Birth
Progesterone receptor agonist
Small molecule
Approved
OTHER
INJECTION; ORAL
Angioedemas, Hereditary; Cytomegalovirus Infections; Depressive Disorder; Depressive Disorder, Major; Diabetes Mellitus; Diabetes Mellitus, Type 2; Epilepsy; Essential Hypertension; Head and Neck Neoplasms; Hepatitis C; HIV Infections; Inflammation; Influenza, Human; Leukemia, Myeloid, Acute; Melanoma; Myelodysplastic Syndromes; Nausea; Neoplasms; Pancreatic Neoplasms; Substance-Related Disorders; von Hippel-Lindau Disease; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Keratosis, Actinic; Non-alcoholic Fatty Liver Disease; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Kaposi; Tachycardia, Supraventricular; Atrial Fibrillation; Cardiovascular Diseases; Heart Failure
Sodium/potassium-transporting ATPase inhibitor
Small molecule
Approved
OTHER
INJECTION
Breast Neoplasms; Colonic Neoplasms; Kidney Neoplasms; Lung Neoplasms; Thyroid Neoplasms; Neuroendocrine Tumors; Leiomyosarcoma; Lymphoma; Lymphoma, T-Cell, Peripheral; Neuroblastoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Synovial; Skin Neoplasms; Hodgkin Disease; Melanoma; Neoplasms
DNA inhibitor
Small molecule
Approved
OTHER; RESPIRATORY
INHALATION; OPHTHALMIC
Osteomyelitis; Bronchopulmonary Dysplasia; Dry Eye Syndromes; Renal Insufficiency, Chronic; Bronchiectasis; Pneumonia, Bacterial; Blepharitis; Cataract; Conjunctivitis, Bacterial; Fractures, Bone; Pneumonia; Pseudomonas Infections; Bacterial Infections; Conjunctivitis, Allergic; Cystic Fibrosis; Eye Infections; Infections; Inflammation
70S ribosome inhibitor
Small molecule
Approved
NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
ORAL
Burning Mouth Syndrome; Neuralgia; Marijuana Abuse; REM Sleep Behavior Disorder; Anxiety; Dementia; Depressive Disorder; Epilepsia Partialis Continua; Epilepsy, Tonic-Clonic; Pain; Schizophrenia; Status Epilepticus; Epilepsy; Panic Disorder; Seizures
GABA-A receptor; anion channel positive allosteric modulator
Small molecule
Approved
OTHER
ORAL; TOPICAL; VAGINAL
Anemia, Sickle Cell; Kidney Diseases; Folliculitis; Candidiasis, Oral; Candidiasis, Vulvovaginal; HIV Infections; Vaginal Discharge; Vaginosis, Bacterial; Candidiasis; Infections; Mycoses; Pruritus; Skin Diseases, Infectious; Tinea; Tinea cruris; Tinea Pedis
Cytochrome P450 51 inhibitor
Small molecule
Approved
OTHER; UROLOGY AND KIDNEY
TRANSDERMAL
Paget Disease, Extramammary; Rhinitis, Allergic, Seasonal; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Enuresis; Hyperhidrosis; Polyneuropathies; Urinary Bladder, Neurogenic; Polyuria; Urinary Bladder, Overactive; Urinary Incontinence; Urinary Incontinence, Urge
Muscarinic acetylcholine receptor M2 antagonist
Small molecule
Approved
OTHER
ORAL
Unknown
Dihydropteroate synthetase inhibitor
Small molecule
Approved
OTHER
ORAL
Amyotrophic Lateral Sclerosis; Angelman Syndrome; Asthma; Hypertension; Hypotension, Orthostatic; Tobacco Use Disorder; Albinism, Oculocutaneous; Aphasia; Attention Deficit Disorder with Hyperactivity; Back Pain; Cocaine-Related Disorders; Fibromyalgia; Macular Degeneration; Multiple Sclerosis; Pain; Retinitis Pigmentosa; Schizophrenia; Spinal Cord Injuries; Amblyopia; Dysautonomia, Familial; Stroke; Parkinson Disease; Parkinson Disease, Postencephalitic; Parkinson Disease, Secondary; Wounds and Injuries
DOPA decarboxylase inhibitor
Small molecule
Approved
OTHER
ORAL
Unknown
GABA-A receptor; anion channel positive modulator
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; OTHER; PREGNANCY AND GYNECOLOGY
INJECTION; INTRAUTERINE; ORAL; VAGINAL
Diabetes Mellitus, Type 1; Anorexia Nervosa; Bulimia Nervosa; Cervical Intraepithelial Neoplasia; Cocaine-Related Disorders; Coronary Disease; Depression, Postpartum; Endometrial Neoplasms; HIV Infections; Marijuana Abuse; Orthostatic Intolerance; Placenta Previa; Polycystic Ovary Syndrome; Pre-Eclampsia; Severe Acute Respiratory Syndrome; Tobacco Use Disorder; Vulvar Lichen Sclerosus; Alzheimer Disease; Angina, Unstable; Bone Diseases, Metabolic; Brain Injuries; Breast Neoplasms; Diabetes Mellitus; Epilepsy; Hypercholesterolemia; Hypertension; Infertility; Infertility, Female; Leiomyoma; Memory Disorders; Menopause; Myocardial Ischemia; Osteoporosis; Ovarian Hyperstimulation Syndrome; Pregnancy; Premature Birth; Thrombosis; Amenorrhea; Endometrial Hyperplasia; Hemorrhage; Uterine Hemorrhage
Progesterone receptor agonist
Protein
Approved
OTHER
INJECTION
Neoplasms; Respiratory Distress Syndrome
Thyrotropin-releasing hormone receptor agonist
Small molecule
Approved
OTHER
TOPICAL
Ectoparasitic Infestations
Unknown
Small molecule
Approved
OTHER
ORAL
Anemia, Aplastic; Dyskeratosis Congenita; Fanconi Anemia; Endometrial Neoplasms; Mastodynia; Myelodysplastic Syndromes; Purpura, Thrombocytopenic, Idiopathic; Purpura, Thrombotic Thrombocytopenic; Infertility; Endometriosis; Fibrocystic Breast Disease
Androgen Receptor agonist
Small molecule
Approved
OTHER
ORAL
Bone Neoplasms; Breast Neoplasms; Glioma; Kidney Neoplasms; Neoplasm Metastasis; Sarcoma; Lung Neoplasms; Lymphoma; Lymphoma, AIDS-Related; Melanoma; Astrocytoma; Central Nervous System Neoplasms; Glioblastoma; Leukemia, Myeloid, Acute; Medulloblastoma; Multiple Myeloma; Brain Neoplasms; Hodgkin Disease; Neoplasms
DNA inhibitor
Small molecule
Approved
OTHER
ORAL
Arthritis, Rheumatoid; Osteoarthritis
Cyclooxygenase inhibitor
Small molecule
Approved
OTHER
INJECTION; OPHTHALMIC
Herpes Simplex; Eye Infections; Virus Diseases
Human herpesvirus 1 DNA polymerase inhibitor
Small molecule
Approved
OTHER
TOPICAL
Unknown
DNA inhibitor
Protein
Approved
OTHER
INJECTION
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL; RECTAL
Premature Birth; Dermatitis, Atopic; Brain Diseases; Constipation
Colonic bacteria substrate
Small molecule
Approved
OTHER
ORAL
Inflammation; Colorectal Neoplasms, Hereditary Nonpolyposis; Distal Myopathies; Alzheimer Disease; Breast Neoplasms; Duodenal Ulcer; Neuralgia; Pleural Effusion; Prostatic Neoplasms; Low Back Pain; Migraine Disorders; Multiple Sclerosis; Osteoarthritis, Hip; Osteoarthritis, Knee; Peptic Ulcer; Severe Acute Respiratory Syndrome; Acute Pain; Arthralgia; Arthritis; Arthritis, Gouty; Arthritis, Juvenile; Arthritis, Rheumatoid; Back Pain; Bursitis; Common Cold; Dysmenorrhea; Fever; Gout; Headache; Muscle Cramp; Myalgia; Osteoarthritis; Pain; Rheumatic Diseases; Spondylitis; Spondylitis, Ankylosing; Stomach Ulcer; Tendinopathy; Toothache; Vaginitis
Cyclooxygenase inhibitor
Protein
Approved
OTHER
INJECTION; SUBCUTANEOUS
Osteoarthritis, Knee; Cognitive Dysfunction; Infertility, Female; Muscular Dystrophy, Facioscapulohumeral; Aging; Amyotrophic Lateral Sclerosis; Brain Injuries; Burns; Crohn Disease; Infertility; Liver Cirrhosis; Mucopolysaccharidosis VI; Muscular Atrophy, Spinal; Sarcopenia; Tendinopathy; Tibial Fractures; Cardiovascular Diseases; Cystic Fibrosis; Diabetes Mellitus; Endocrine System Diseases; Fetal Growth Retardation; Growth Disorders; Heart Failure; HIV Wasting Syndrome; Hypopituitarism; Noonan Syndrome; Obesity; Osteogenesis Imperfecta; Spinal Cord Injuries; Cachexia; Dwarfism; Dwarfism, Pituitary; HIV Infections; Infant, Small for Gestational Age; Pituitary Diseases; Prader-Willi Syndrome; Renal Insufficiency, Chronic; Short Bowel Syndrome; Turner Syndrome
Growth hormone receptor agonist
Small molecule
Approved
OTHER
ORAL
Diabetic Nephropathies; Peripheral Arterial Disease; Hyperlipidemias; Cardiovascular Diseases
ATP-binding cassette sub-family A member 1 inhibitor
Small molecule
Approved
OTHER
ENDOCERVICAL; VAGINAL
Pain; Pregnancy
Prostaglandin E2 receptor agonist
Small molecule
Approved
OTHER
INTRATHECAL; ORAL
Substance-Related Disorders; Autistic Disorder; Liver Cirrhosis, Alcoholic; Obesity; Carcinoma, Hepatocellular; Cocaine-Related Disorders; Marijuana Abuse; Paget Disease, Extramammary; Pain; Tobacco Use Disorder; Alcoholism; Charcot-Marie-Tooth Disease; Gastroesophageal Reflux; Substance Withdrawal Syndrome; Brain Injuries; Brain Injuries, Traumatic; Cerebral Palsy; Multiple Sclerosis; Muscle Contraction; Muscle Rigidity; Muscle Spasticity; Spinal Cord Diseases; Spinal Cord Injuries
GABA-B receptor agonist
Small molecule
Approved
OTHER
TOPICAL
Psoriasis; Skin Diseases
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
ORAL
Unknown
Histamine H1 receptor antagonist
Small molecule
Approved
DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER
ORAL
Atrophy; Breast Neoplasms; Hypogonadism; Menopause; Primary Ovarian Insufficiency
Estrogen receptor agonist
Small molecule
Approved
OTHER
ORAL; VAGINAL
Atrophy; Hypogonadism; Menopause; Osteoporosis; Primary Ovarian Insufficiency
Estrogen receptor alpha agonist
Small molecule
Approved
OTHER; RESPIRATORY
ORAL
Hypersensitivity; Multiple Sclerosis; Common Cold; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Urticaria
Histamine H1 receptor antagonist
Small molecule
Approved
OTHER
TOPICAL
Unknown
Glucocorticoid receptor agonist
Small molecule
Approved
GASTROINTESTINAL; OTHER
ORAL
Amyotrophic Lateral Sclerosis; Anxiety Disorders; Pulmonary Disease, Chronic Obstructive; Breast Carcinoma In Situ; Endometrial Neoplasms; Dermatitis, Atopic; Gastrointestinal Hemorrhage; Hemorrhage; Ulcer; Duodenal Ulcer; Gastroesophageal Reflux; Heartburn; Peptic Ulcer
Histamine H2 receptor antagonist
Small molecule
Approved
OTHER
INJECTION; ORAL
Alzheimer Disease; Depressive Disorder, Major; Obsessive-Compulsive Disorder; Substance-Related Disorders; Voice Disorders; Alcoholism; Amphetamine-Related Disorders; Cocaine-Related Disorders; Delirium; Epilepsy; Epilepsy, Reflex; Pain; Seizures; Substance Withdrawal Syndrome; Dementia; Epilepsia Partialis Continua; Psychomotor Agitation; Psychotic Disorders; Schizophrenia; Vertigo; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Status Epilepticus
GABA-A receptor; anion channel positive allosteric modulator