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Total: 6532
Small molecule
Approved
Unknown
Unknown
Anemia; HIV Infections; Malaria; Malaria, Falciparum; Malaria, Vivax; Pneumonia, Pneumocystis; Pregnancy; Premature Birth
Dihydropteroate synthetase inhibitor
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Pulmonary Disease, Chronic Obstructive; Tuberculosis; Pneumonia; Cystic Fibrosis; Mycobacterium Infections; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Bacterial Infections; Eye Infections
Unknown
Small molecule
Approved
OTHER
INJECTION; TOPICAL
Leukemia; Myopia; Neoplasm Metastasis; Renal Insufficiency, Chronic; Urethral Stricture; Appendiceal Neoplasms; Biliary Tract Neoplasms; Carcinoma, Squamous Cell; Cholangiocarcinoma; Cholangitis, Sclerosing; Corneal Opacity; Esophageal Stenosis; Glaucoma, Neovascular; Glaucoma, Open-Angle; Keratoconus; Liver Neoplasms; Pterygium; Sarcoma; Anus Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma in Situ; Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colorectal Neoplasms; Head and Neck Neoplasms; Lung Neoplasms; Mesothelioma; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Adenocarcinoma; Glaucoma; Neoplasms
DNA inhibitor
Small molecule
Approved
CARDIOVASCULAR; OTHER; UROLOGY AND KIDNEY
INJECTION; URETHRAL
Arteriosclerosis Obliterans; Optic Neuropathy, Ischemic; Peripheral Arterial Disease; Peripheral Vascular Diseases; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Sexual Dysfunction, Physiological; Heart Failure; Macular Degeneration; Prostatic Neoplasms, Castration-Resistant; Cardiovascular Diseases; Ductus Arteriosus, Patent; Erectile Dysfunction
Prostanoid EP1 receptor agonist
Small molecule
Approved
OTHER
ORAL
Anxiety
GABA-A receptor; anion channel positive allosteric modulator
Small molecule
Approved
OTHER
ORAL
Multiple Sclerosis; Sunburn; Angioedema; Conjunctivitis, Allergic; Hypersensitivity; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor; Urticaria
Histamine H1 receptor antagonist
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Bacterial Infections
Unknown
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Appendicitis; Peritonitis; Sepsis; Bacterial Infections
Unknown
Small molecule
Unknown
Unknown
Unknown
Cardiovascular Diseases; Hodgkin Disease; Atrial Fibrillation; Heart Failure; Arrhythmias, Cardiac; Diabetes Mellitus; Hypertension
Voltage-gated L-type calcium channel blocker
Small molecule
Approved
IMMUNE SYSTEM; OTHER
ORAL; TOPICAL
Glioblastoma; Insulin Resistance; Alzheimer Disease; Asthma; Diabetes Mellitus, Type 2; Erectile Dysfunction; Essential Hypertension; Gastroparesis; Hepatitis C; Immune System Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Multiple Sclerosis; Nausea; Neuroblastoma; Osteoporosis; Premature Birth; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Burns; Hypogonadism; Neoplasms; Prostatic Neoplasms; Psoriasis; Acne Vulgaris; Candidiasis, Vulvovaginal; Dermatitis; Prostatic Neoplasms, Castration-Resistant; Respiratory Distress Syndrome; Vaginosis, Bacterial; Adrenal Gland Diseases; Blastomycosis; Dermatitis, Seborrheic; Onychomycosis; Tinea; Tinea Pedis
Cytochrome P450 51 inhibitor
Small molecule
Unknown
Unknown
Unknown
Amyotrophic Lateral Sclerosis; Depression; Depressive Disorder; Depressive Disorder, Major
Serotonin 2a (5-HT2a) receptor antagonist
Small molecule
Approved
Unknown
Unknown
Osteomyelitis
Bacterial penicillin-binding protein inhibitor
Small molecule
Approved
OTHER
ORAL
Adrenal Hyperplasia, Congenital; Substance-Related Disorders; Anus Diseases; Epilepsies, Partial; Fissure in Ano; Proteinuria; Renal Insufficiency, Chronic; Diabetic Nephropathies; Hypertension, Pulmonary; Kidney Calculi; Myocardial Ischemia; Placenta Previa; Premature Birth; Raynaud Disease; Cardiovascular Diseases; Coronary Vasospasm; Hypertension
Voltage-gated L-type calcium channel blocker
Small molecule
Approved
CARDIOVASCULAR; GASTROINTESTINAL; OTHER
INJECTION; INTRA-ANAL; SUBLINGUAL; TRANSDERMAL
Colorectal Neoplasms; Hypotension; Peripheral Arterial Disease; Hypertension, Pulmonary; Infections; Inflammation; Phlebitis; Rectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Diabetic Neuropathies; Erectile Dysfunction; Hot Flashes; Lung Neoplasms; Shock; Tendinopathy; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Muscle Cramp; Myocardial Ischemia; Osteoporosis; Raynaud Disease; Reperfusion Injury; Scleroderma, Localized; Stroke; Wounds and Injuries; Angina Pectoris; Angina, Stable; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Heart Failure; Hemorrhoids; Hypertension; Myocardial Infarction; Pain
Soluble guanylate cyclase activator
Small molecule
Unknown
Unknown
Unknown
Hepatitis C; Anemia, Sickle Cell; Carcinoma, Squamous Cell; Depressive Disorder; Rotator Cuff Injuries; Stress Disorders, Post-Traumatic; Toothache; Back Pain; Cocaine-Related Disorders; Depressive Disorder, Major; Heroin Dependence; HIV Infections; Intervertebral Disc Degeneration; Low Back Pain; Morphine Dependence; Neonatal Abstinence Syndrome; Neuralgia; Osteoarthritis; Substance Withdrawal Syndrome; Acute Pain; Chronic Pain; Drug Overdose; Opioid-Related Disorders; Pain; Substance-Related Disorders
Kappa opioid receptor agonist
Small molecule
Approved
OTHER
INHALATION; NASAL
Rhinitis, Allergic, Perennial; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Rhinitis
Glucocorticoid receptor agonist
Small molecule
Approved
OTHER
INJECTION
Breast Neoplasms
Unknown
Small molecule
Approved
Unknown
Unknown
Sleep Apnea, Obstructive; Alcoholism; Diabetic Neuropathies; Alzheimer Disease; Anxiety; Dementia; Depressive Disorder, Major; Schizophrenia; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Depressive Disorder
Unknown
Small molecule
Approved
OTHER
INJECTION; ORAL
Osteoporosis; Stress Disorders, Post-Traumatic; Atrial Fibrillation; Cerebrovascular Disorders; Essential Hypertension; Heart Diseases; Heart Failure; Hemangioma; Hypertrophy, Left Ventricular; Marfan Syndrome; Mitral Valve Stenosis; Myocardial Ischemia; Angina Pectoris; Angina, Stable; Cardiovascular Diseases; Coronary Artery Disease; Diabetes Mellitus; Hypertension; Myocardial Infarction; Stroke
Beta-1 adrenergic receptor antagonist
Small molecule
Approved
Unknown
Unknown
Hypotension, Orthostatic; Orthostatic Intolerance; Depressive Disorder; Hypotension; Myocardial Infarction; Hypertension
Unknown
Small molecule
Approved
Unknown
Unknown
Hypersensitivity
Unknown
Small molecule
Approved
Unknown
Unknown
Attention Deficit Disorder with Hyperactivity; Cystic Fibrosis; Coronary Disease; Demyelinating Diseases; Hyperparathyroidism, Primary; Migraine with Aura; Multiple Sclerosis, Chronic Progressive; Optic Neuritis; Hypertension; Cardiovascular Diseases
Unknown
Small molecule
Approved
OTHER
ORAL
Unknown
GABA-A receptor; anion channel positive allosteric modulator
Small molecule
Approved
Unknown
Unknown
Hypertension
Unknown
Small molecule
Approved
Unknown
Unknown
Bacterial Infections
Unknown
Small molecule
Approved
OTHER
INJECTION
Unknown
Unknown
Small molecule
Approved
OTHER
ORAL
Unknown
Adenosine receptor antagonist
Small molecule
Approved
Unknown
Unknown
Osteomyelitis; Bacterial Infections
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Helminthiasis
Unknown
Small molecule
Unknown
Unknown
Unknown
Unknown
Unknown
Small molecule
Approved
Unknown
Unknown
Multiple Sclerosis, Relapsing-Remitting
Unknown
Small molecule
Approved
Unknown
Unknown
Osteoarthritis; Cataract; Kidney Calculi; Tension-Type Headache; Nephrocalcinosis; Renal Insufficiency
Unknown
Small molecule
Approved
Unknown
Unknown
Alzheimer Disease; Bipolar Disorder; Cystic Fibrosis; Depressive Disorder, Major; Pulmonary Disease, Chronic Obstructive; Obesity; Brain Injuries; Brain Ischemia; Delirium; Hypothermia; Obsessive-Compulsive Disorder; Panic Disorder; Coronary Disease
Unknown
Small molecule
Approved
Unknown
Unknown
Unknown
Unknown